CAS: 480-10-4; 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-3-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One

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CAS号133-89-1 尿苷二磷酸葡萄糖 | CAS号520-18-3 山奈酚 | CAS号152390-63-1 camelliaside C | CAS号56317-05-6 山奈酚 3-O-(6''-没食... | CAS号23405-70-1 5,7-BIS-(BENZYL... | CAS号96333-59-4 5,7-BIS-(BENZYL... | CAS号59-23-4 半乳糖 | CAS号520-18-3 山奈酚 | CAS号10257-28-0 D-吡喃葡萄糖 | CAS号99-96-7 4-羟基苯甲酸 | CAS号50-99-7 D(+)-无水葡萄糖 | CAS号2280-44-6 D-glucopyranose | CAS号492-61-5 β-D-葡萄糖 | CAS号108-73-6 间苯三酚

5,7-二-(苄氧基)-2-(4-(苄氧基)苯基)-4H-苯并吡喃-4-酮置于甲醇,氢气,Sodium Methylate,二甲基二环氧乙烷,Palladium(II) Hydroxide,Potassium Carbonate,溶剂黄146体系中,用 四氢呋喃,甲醇,二氯甲烷,水,N,N-二甲基甲酰胺,丙酮 作为反应溶剂,化学反应 16.0H,反应生成 紫云英苷
参考文献:Study Of Kaempferol Glycoside As An Insulin Mimic Reveals Glycon To Be The Key Active Structure
标题:Study Of Kaempferol Glycoside As An Insulin Mimic Reveals Glycon To Be The Key Active Structure
摘要:Diabetes Mellitus Is Increasing In Prevalence With Patient Numbers Rising Throughout The World. Current Treatments For-Diabetes Mellitus Focus On Control Of Blood Glucose Levels. Certain Kinds Of Flavonoids Or Their Glycosides Stimulate Cells To Improve Glucose Uptake And Lower Blood Glucose Levels. We Synthesized Kaempferol 3-O-Neohesperidoside (1) A Naturally occurring Substance Present In Cyathea Phalerata Mart.,Reported To Mimic The Action Of Insulin. Synthetic 1 Promoted Glucose Uptake In The Cultured Cell Line,L6. Further Studies To Determine The Core Structure Responsible For This Activity Using Synthetic Compounds Revealed Neohesperidose To Be The Primary Pharmacophore. These Findings Support The Use Of Certain Saccharides As A Potential Novel Treatment For Diabetes Mellitus By Replacing Or Supporting Insulin.
DOI:10.1021/ml100171X

专利信息

专利号:US-2012208198-A1
优先权日:2007-01-11
标 题:Novel gene encoding myb transcription factor involved in proanthocyanidin synthesis
发明人：BOGS JOCHEN; WALKER AMANDA RUTH; ROBINSON SIMON PIERS
权利人:BOGS JOCHEN; WALKER AMANDA RUTH; ROBINSON SIMON PIERS; COMMW SCIENT IND RES ORG
摘要:An isolated or recombinant MYB polypeptide having activity as a transcription factor in the synthesis of proanthocyanidins in plants, and nucleic acid molecule encoding same, wherein the polypeptide activates in the plants (a) promoters of the leucoanthocyanidin (LAR) and anthocyanidid reductase (ANR) genes, and (b) promoters of at least two of the genes of the general flavonoid pathway. Use of the polypeptide and nucleic acid molecule in regulating the biosynthesis and accumulation of proanthocyanidins in plants, such as in modifying pasture quality of legumes, is also disclosed.

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-7914823-B2
优先权日:2000-12-21
标题 :Method and composition for the topical treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD ALLEN
权利人:PROPHASE LABS INC
摘要:A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recovery of the damaged nerve tissues.

专利号:US-2025257331-A1
优先权日:2024-02-09
标题 :FLAVONOID GLYCOSIDE GLYCOSYLTRANSFERASE LbUGT71BX1 IN LAPORTEA BULBIFERA AS WELL AS THE CODING GENE AND THE USE THEREOF
发明人：WU LAN; XIANG LI; GAO RANRAN; CHEN SHILIN; SHI YUHUA; YIN QINGGANG; WANG MENGYUE; CHU YANG; WANG WENTING
权利人:INST CHINESE MATERIA MEDICA CHINA ACADEMY OF CMS
摘要:The invention discloses a flavonoid glycoside glycosyltransferase LbUGT71BX1 in laportea bulbifera as well as the coding gene and the use thereof. The amino acid sequence of the flavonoid glycoside glycosyltransferase LbUGT71BX1 is shown as SEQ ID NO: 2. The nucleotide sequence of the coding gene of the flavonoid glycoside glycosyltransferase LbUGT71BX1 is shown as SEQ ID NO: 1. According to the invention, on the basis of relevant results of the second-generation transcriptome and the third-generation full-length transcriptome sequencing of the laportea bulbifera , the last-step key enzyme LbUGT71BX1 for the synthesis of the flavonoid glycoside in the laportea bulbifera is screened and identified by using a reverse genetics method, filling the terminal blank of the biosynthesis pathway of the flavonoid glycoside in the laportea bulbifera.

专利号:CN-110184247-B
优先权日:2019-05-09
标 题:Melatonin synthesis gene MsASMT in alfalfa and its application in regulating the synthesis of melatonin and flavonoids in plants

专利号:CN-120192941-A
优先权日:2025-02-28
标 题:Pea C-glycosyltransferase and application thereof in synthesis of SGLT-2 inhibitor