CAS: 49845-33-2; 2,4-Dichloro-5-Nitropyrimidine

相似化合物

5177-27-5 4359-87-9 4316-93-2

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CAS号611-08-5 5-硝基尿嘧啶 | CAS号10025-87-3 三氯氧磷 | CAS号7647-01-0 盐酸 | CAS号14623-57-5 2,4-dithio-5-ni... | CAS号622-16-2 2-氯-5-异氰酸硝基苯 | CAS号5177-27-5 5-氨基-2,4-二氯嘧啶 | CAS号289-95-2 嘧啶 | CAS号611-08-5 5-硝基尿嘧啶 | CAS号160948-35-6 2-氨基-4-氯-5-硝基嘧啶 | CAS号18620-73-0 2,4-二氨基-5-硝基嘧啶 | CAS号1920-66-7 4-氨基-2-氯-5-硝基嘧啶 | CAS号1131-14-2 (2-氯-5-硝基-嘧啶-4-... | CAS号755039-53-3 (2R)-2-[(2-氯-5-...

5-硝基尿嘧啶置于4-二甲氨基吡啶,氯化亚砜,三光气体系中,化学反应 13.5H,以75%的收率获得产物2,4-二氯-5 硝基嘧啶
参考文献:氮杂氮杂戊烯的高效无磷氯化反应及其在一锅法药物合成中的应用
标题:氮杂氮杂戊烯的高效无磷氯化反应及其在一锅法药物合成中的应用
摘要:用碳酸二(三氯甲基)酯(btc)和socl 2氯化羟基氮杂芳烃已经通过与5重量%的4-二甲基氨基吡啶(dmap)作为催化剂回流而有效地进行.各种底物都可以高产率氯化.所获得的氯化氮杂芳烃可通过简单的后处理直接直接用于大规模的一锅合成.
DOI:10.1021/acs.Oprd.9B00407

专利信息

专利号:US-7897762-B2
优先权日:2006-09-14
标 题:Kinase inhibitors useful for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:DECIPHERA PHARMACEUTICALS LLC
摘要:The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-2008242861-A1
优先权日:2007-04-02
标题 :Synthesis of amino-protected cyclohexane-1,4-diyldimethanamine and its derivatives
发明人：YEN CHI-FENG; HUANG CHANG-PIN; HU CHENG-KUNG; CHOU MING-CHEN; KING CHI-HSIN RICHARD
权利人:YEN CHI-FENG; HUANG CHANG-PIN; HU CHENG-KUNG; CHOU MING-CHEN; KING CHI-HSIN RICHARD
摘要:This invention relates to methods of preparing the compounds of formula (V): n n n n n n n n n n Each variable in this formula is defined in the specification.

专利号:US-5998629-A
优先权日:1998-12-02
标题 :Synthesis of pyrazolotriazole photographic dye forming color couplers and intermediates
发明人：BOSE JUDITH A; VALENTE RONALD R; AIMINO DINO; DEMEJO DEBORAH D
权利人:EASTMAN KODAK CO
摘要:Photographic pyrazolotriazole dye forming coupler compound or coupler intermediate compounds can be readily prepared by inducing an elimination-addition reaction between certain pyrazolotriazole compounds and aromatic amines in the presence of an inorganic base or formate. Yields and purity are high, and reaction time is reduced with the specific set of conditions and reactants, and environmental impact from waste is reduced. The resulting compounds can be used themselves as photographic dye forming couplers or further reacted to prepare useful coupler compounds for photographic use.

专利号:US-9573939-B2
优先权日:2011-09-08
标题:Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
发明人：MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; DANG QUN
权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; DANG QUN; MERCK SHARP & DOHME; MSD ITALIA SRL
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-6008369-A
优先权日:1998-12-02
标题 :One-pot synthesis of pyrazolotriazole photographic dye forming color couplers and coupler intermediates
发明人：VALENTE RONALD R; BOSE JUDITH A
权利人:EASTMAN KODAK CO
摘要:Photographic pyrazolotriazole dye forming coupler compounds of coupler intermediate compounds can be readily prepared in a single reaction medium by reacting certain pyrazolotriazole compounds with nitro-substituted aromatic compounds in the presence of a formate salt and a transition metal catalyst. This salt hydrogenates the nitro group and the carbonate by-product induces reaction of the resulting amine with the pyrazolotriazole compound. Yields and purity are high, and reaction time is reduced with the specific set of conditions and reactants, and environmental impact from waste is reduced. In addition, isolation of aromatic amine intermediates is avoided. The resulting pyrazolotriazole compounds can be used themselves as photographic dye forming couplers or further reacted to prepare useful coupler compounds for photographic use.

专利号:US-9068023-B2
优先权日:2012-03-09
标 题:Continuous process for the synthesis of graft polymers based on polyethers
发明人：EL-TOUFAILI FAISSAL-ALI; HEUSSLER MICHAELA; SCHWEDE CHRISTIAN; FLORES-FIGUEROA AARON; DOBRAWA RAINER; BOECKH DIETER; LOTH WOLFGANG; KONRAD GERD
权利人:BASF SE
摘要:The invention relates to a continuous process for the preparation of amphiphilic graft polymers, wherein a vinyl ester component (B) composed of vinyl acetate and/or vinyl propionate (B1) and, if desired, a further ethylenically unsaturated monomer (B2), is polymerized in the presence of a polyalkylene oxide (A), a free radical-forming initiator (C) and, if desired, an additive (D), at a mean polymerization temperature at which the initiator (C) has a decomposition half-time of from 1 to 500 min, in at least one tubular reactor segment with a feed side and an outlet side, through which the reaction mixture comprising at least a part of component (A) to (C), and if desired (D), streams, a tubular reactor segment and the use of the inventive amphiphilic graft polymer. The invention further relates to an inventive amphiphilic graft polymer and the use thereof.