CAS: 5339-26-4; 1-(2-Bromoethyl)-4-Nitrobenzene

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CAS号103-63-9 β-溴苯乙烷 | CAS号100-12-9 对乙基硝基苯 | CAS号100-27-6 对硝基苯乙醇 | CAS号104-03-0 对硝基苯乙酸 | CAS号50434-36-1 2-(4-硝基苯基)乙酰氯 | CAS号555-21-5 4-硝基苯乙腈 | CAS号148960-51-4 4-[2-(苯基磺酰基)乙基]苯胺 | CAS号51-67-2 酪胺 | CAS号210158-20-6 4-(2-(4-硝基苯基)乙基)吗啉 | CAS号192775-41-0 2-(4-硝基苯基)乙烷磺酸 | CAS号20264-96-4 1-(2-碘乙基)-4-硝基苯 | CAS号26407-07-8 4-(2-溴乙基)苯胺盐酸盐 | CAS号82925-01-7 1,2,3,4-四氢-6,7-... | CAS号82925-02-8 4-[2-(3,4-二氢-6,... | CAS号100-13-0 4-硝基苯乙烯

4-硝基苯乙烯置于偶氮二异丁腈,氢溴酸体系中,用 甲苯 作为反应溶剂,化学反应 2.0H,以73%的收率获得产物4-硝基苯乙基溴
参考文献:脂族和芳族烯烃的可扩展抗马尔科夫尼科夫加氢溴化反应†
标题:脂族和芳族烯烃的可扩展抗马尔科夫尼科夫加氢溴化反应†
摘要:为了改善获得关键合成中间体的途径,我们的目标是直接进行氢溴化-根岸路线.毫不奇怪,在aibn的存在下,将溴化氢在马齿中添加反马尔可夫尼可夫成功.然而,即使在没有添加引发剂的情况下,也观测到了反马尔科夫尼科夫的加入.对早期报道的重新检查表明,除非排除了空气,否则在溴化氢中并不总是观测到选择性马尔科夫尼科夫加法,通常简称为"正常"加法,导致重新发现了可重现且可扩展的无引发剂方案.
DOI:10.1039/c6Ob00692B

专利信息

专利号:US-6248891-B1
优先权日:1997-05-23
标题:Synthesis of acridine derivative multidrug-resistant inhibitors
发明人：SHARP MATTHEW JUDE; MADER CATHERINE J; STRACHAN CALUM
权利人:GLAXO WELLCOME INC
摘要:Synthesis of the MDRI of formula (I) from intermediates of acridone acid of formula (II) and aminophenethyl isoquinoline of formula (III), via steps including coupling and conversion to yield the MDRI of formula (I).

专利号:WO-2005103035-A1
优先权日:2004-04-23
标题:Modified fischer indole synthesis of eletriptan
发明人：ASHCROFT CHRISTOPHER PAUL
权利人:PFIZER LTD; ASHCROFT CHRISTOPHER PAUL; PFIZER
摘要:The present invention relates to a new process for the preparation of eletriptan (I), or its enantiomer comprising a modified Fischer indole synthesis, namely the reaction of a compound of formula (II), wherein R1 is a suitable hydrazine protecting group, with a compound of formula (III) wherein R2 is an aldehyde group (-CHO) or the functional equivalent thereof.

专利号:US-9115172-B2
优先权日:2007-01-11
标 题 :Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
发明人：D SOUZA CHRISTOPHER A; MCBRIDE WILLIAM J; GOLDENBERG DAVID M
权利人:IMMUNOMEDICS INC
摘要:The present application discloses compositions and methods of synthesis and use of 18 F- or 19 F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18 F or 19 F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may then be directly or indirectly attached to the targeting molecule. In other embodiments, the 18 F or 19 F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the bifunctional chelating agent bound to 18 F- or 19 F-metal complex may be conjugated to the molecule to be labeled at a reduced temperature, e.g. room temperature.

专利号:US-2016045626-A1
优先权日:2007-01-11
标题 :Methods and Compositions for Improved Labeling of Targeting Peptides
发明人：MCBRIDE WILLIAM J; GOLDENBERG DAVID M
权利人:IMMUNOMEDICS INC
摘要:The present application discloses compositions and methods of synthesis and use of labeled targeting peptides, such as octreotide, octreotate, or other somatostatin analogs or derivatives. The targeting peptide may be labeled with a therapeutic or diagnostic isotope, such as 61 Cu, 62 Cu, 64 Cu, 67 Cu, 18 F, 19 F, 66 Ga, 67 Ga, 68 Ga, 72 Ga, 111 In, 177 Lu, 44 Sc, 47 Sc, 86 Y, 88 Y, 90 Y, 45 Ti or 89 Zr, preferably 18 F or 19 F. More preferably, the targeting peptide is NOTA-octreotate, NOTA-MPAA-octreotate, pyridine-NOTA-octreotate or triazole-NOTA-octreotate. The labeled targeting peptides may be used for detection, diagnosis, imaging and/or treatment of sst 2 + tumors, such as neuroendocrine tumors.

专利号:US-9028800-B2
优先权日:2007-01-11
标 题 :Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
发明人：D SOUZA CHRISTOPHER A; MCBRIDE WILLIAM J; GOLDENBERG DAVID M
权利人:IMMUNOMEDICS INC
摘要:The present application discloses compositions and methods of synthesis and use of 18 F or 19 F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18 F or 19 F is conjugated to a targeting molecule by formation of a complex with a group IIIA metal and binding of the complex to a bifunctional chelating agent, which may be directly or indirectly attached to the targeting molecule. In other embodiments, the 18 F or 19 F labeled moiety may comprise a targetable construct used in combination with a bispecific antibody to target a disease-associated antigen. The disclosed methods and compositions allow the simple and reproducible labeling of molecules at very high efficiency and specific activity in 30 minutes or less. In preferred embodiments, the labeled molecule may be used for imaging in a subject without purification after labeling.

专利号:WO-9852923-A1
优先权日:1997-05-23
标题:Synthesis of acridine derivative multidrug-resistant inhibitors