过氧化氢酶置于乙醇,Potassium Carbonate,Sodium Hydroxide体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 4-丙氧基苯甲酸 参考文献:Synthesis And Study Of Vitrescent Materials Based On The Alkoxybenzoic Acids Derivatives And Triethanolamine 标题:Synthesis And Study Of Vitrescent Materials Based On The Alkoxybenzoic Acids Derivatives And Triethanolamine 摘要:Fifteen New Branched Triethanolamine Esters Of The Benzoic Acid Derivatives Were Designed And The Mesomorphism Typical Of Discotic Mesogens Was Forecast For Them. In Eight Of The Obtained Compounds A Manifestation Of Liquid Crystal Properties Was Predicted,For Four Derivatives Equiprobable Prognosis Was Given,And Only Three Compounds Were Predicted Not To Form A Mesophase. The Obtained Esters Were Characterized By Elemental Analysis,NMR And Ir Spectroscopy,Gas Chromatography-Mass Spectrometry. The Main Thermal Characteristics That Allow Accounting For Their Phase Behavior Were Determined. DOI:10.1134/s1070363213040075
专利号:US-9175357-B2 优先权日:2011-02-04 标 题:Fragment ligated inhibitors selective for the polo box domain of PLK1 发明人:MCINNES CAMPBELL; FARAG DOAA BOSHRA 权利人:MCINNES CAMPBELL; FARAG DOAA BOSHRA; UNIV SOUTH CAROLINA 摘要:Methods for developing non-peptidic inhibitors that target the polo-box domain of PLK1 proteins are described. Methods include developing structure activity relationships for peptidic inhibitors followed by development of non-peptide fragment alternatives for portions of the peptide inhibitors. The non-peptide fragment can provide similar structure activity relationship as the replaced peptide. Fragment alternatives to key binding determinants are identified in an iterative computational and synthetic process facilitated through understanding of the peptide structure-activity relationships. The approach is informed by peptide structure-activity data obtained through synthesis and testing of truncated and mutated analogs of known PBD binding motifs.
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
专利号:US-2008176857-A1 优先权日:2005-03-25 标题 :4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors 发明人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH 权利人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: n n n n n n n n n n wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2 , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:CN-1923793-A 优先权日:2006-10-09 标 题 :Synthesis method of aryl phenyl ester like compound
专利号:EP-0260415-B1 优先权日:1986-08-01 标题:Synthesis and application of high molecular weight polyanhydrides