CAS: 619-65-8; 4-Cyanobenzoic Acid

上下游产品

CAS号874-89-5 羟甲基 | CAS号214360-44-8 4-氰基苯硼酸新戊二醇酯 | CAS号124-38-9 二氧化碳 | CAS号17201-43-3 α-溴对甲基苯甲腈 | CAS号3034-34-2 4-氰基苯甲酰胺 | CAS号105-07-7 对氰基苯甲醛 | CAS号10406-25-4 4-氰基苯甲胺 | CAS号201230-82-2 carbon monoxide | CAS号3058-39-7 4-碘苯甲腈 | CAS号104-85-8 对甲苯腈 | CAS号60695-02-5 4'-CYANO-3-PHEN... | CAS号49744-93-6 3-氧代-3-对氰基苯基丙酸乙酯 | CAS号43038-36-4 4-氰基苯肼 | CAS号340736-76-7 4-(5-(三氟甲基)-1,2... | CAS号34114-12-0 4-(1H-四唑-5-基)苯甲酸 | CAS号455-18-5 对三氟甲基苯腈 | CAS号330942-05-7 贝曲西班 | CAS号6068-72-0 4-氰基苯甲酰氯 | CAS号143330-23-8 4-[(4-氰基苯甲酰基)氨基]苯甲酸 | CAS号17930-02-8 2-(4-氰基苯基)苯并噻唑

对甲基苯甲酸置于盐酸羟胺,2,4,6-Triphenylpyrylium Tetrafluoroborate,氧气,溴化铵体系中,用 乙腈 作为反应溶剂,40.0 °C,100.0 Kpa 条件下,反应 24.0H,以82%的收率获得产物对氰基苯甲酸
参考文献:可见光促进 C(Sp3)−h 键无金属合成(杂)芳香腈**
标题:可见光促进 C(Sp3)−h 键无金属合成(杂)芳香腈**
摘要:C(Sp 3)−h 键的无金属活化反应生成增值产品在有机合成中至关重要.我们报道了使用市售有机染料 2,4,6-三苯基吡喃鎓四氟硼酸盐 (Tpp) 通过光催化过程将甲基芳烃转化为相应的芳基腈.应用这种方法,在不含金属和氰化物的条件下,可以以非常好到优异的产率合成多种氰基苯.我们通过 50 多个示例证明了该方法的范围,包括药物分子(塞来昔布)的后期功能化和l-薄荷醇,氨基酸和胆固醇衍生物等复杂结构.此外,所提出的合成方案适用于克级反应.除了甲基芳烃之外,还展示了醛,醇和肟氰化的选定示例.使用时间分辨发光猝灭研究,控制实验,核磁共振波谱以及动力学研究进行了详细的机理研究,所有这些都支持了所提出的催化循环.
DOI:10.1002/anie.202011815

专利信息

专利号:US-2008287649-A1
优先权日:2006-12-29
标 题 :Methods for the synthesis of cyclic peptides
发明人：CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
权利人:CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
摘要:Methods for the synthesis of cyclic peptides are provided, as well as novel dipeptide compounds. The methods include the solid phase synthesis of a dipeptide, which is the coupled to a second peptide in a solid phase reaction. The peptide is then cyclized following the coupling reaction. The methods and dipeptides are particularly useful for the synthesis of MC-4 receptor agonist peptides.

专利号:EP-1960423-B1
优先权日:2004-12-30
标 题:Synthesis of peptide t-20 using peptide intermediate fragments
发明人：HAN YEUN-KWEI; JOHNSTON DAVID A; KHATRI HIRALAL N
权利人:HOFFMANN LA ROCHE
摘要:Methods for the solid phase synthesis of T-20 peptides and peptide intermediates, in particular methods involving synthesizing T-20 peptide intermediates at low loading factors to produce products having excellent purity and yield.

专利号:US-3772389-A
优先权日:1971-06-24
标 题:Process for the synthesis of phenyl esters
发明人：LOWRANCE W
权利人:EASTMAN KODAK CO
摘要:A PROCESS FOR THE SYNTHESIS OF PHENYL ESTERS DIRECTLY FROM THE CORRESPONDING PHENOLS AND CARBOXYLIC ACIDS WHICH COMPRISES CONTACTING A PHENOLIC COMPOUND HAVING AT LEAST ONE HYDROGEN ATOM ADJACENT THE ACTIVE HYDROXYL GROUP WITH A CARBOXYLIC ACID COMPOUND CONTAINING AT LEAST ONE ACTIVE CARBOXYLIC GROUP IN THE PRESENCE OF A CATALYTIC AMOUNT OF A BORATE-SULFURIC ACID CATALYST COMPLEX. THE PROCESS IS CARRIED OUT IN A SINGLE STAGE REACTOR WHICH MAY BE OPERATED AT FROM 75*C. TO 285*C. UNDER ATMOSPHERIC, SUBATMOSPHERIC OR SUPERATMOSPHERIC PRESSURE. IF DESIRABLE, A SOLVENT CAN BE EMPLOYED.

专利号:EP-1833843-B1
优先权日:2004-12-30
标 题:Synthesis of peptide t-20 using peptide intermediate fragments
发明人：HAN YEUN-KWEI; JOHNSTON DAVID A; KHATRI HIRALAL N
权利人:HOFFMANN LA ROCHE
摘要:Methods for the solid phase synthesis of T-20 peptides and peptide intermediates, in particular methods involving synthesizing T-20 peptide intermediates at low loading factors to produce products having excellent purity and yield.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:US-7544665-B2
优先权日:2004-12-30
标题 :Synthesis using peptide intermediate fragments
发明人：KHATRI HIRALAL N; HAN YEUN-KWEI; JOHNSTON DAVID A; HODGES L MARK
权利人:ROCHE COLORADO CORP
摘要:Methods for the solid phase synthesis of T-1249 peptides and peptide intermediates, in particular methods involving synthesizing T-1249 peptide intermediates at low loading factors to produce products having excellent purity and yield.