CAS: 62774-90-7; 2,6-Dichloro-4-Methylnicotinic Acid

相似化合物

875-35-4 1013648-04-8 91591-70-7

上下游产品

CAS号38841-54-2 2,6-二氯-4-甲基烟酰胺 | CAS号875-35-4 2,6-二氯-4-甲基-3-吡啶氰 | CAS号91591-70-7 2,6-二氯-4-甲基烟碱醛 | CAS号5444-02-0 2,6-二羟基-3-氰基-4-甲基吡啶 | CAS号108130-10-5 2,6-二氯-4-甲基-3-吡啶羧酸乙酯 | CAS号1013648-04-8 2,6-二氯-4-甲基烟酸甲酯 | CAS号91591-70-7 2,6-二氯-4-甲基烟碱醛

3-氰基-4-甲基-2,6-二氯吡啶置于sodium Chlorite,Sodium Dihydrogenphosphate,二异丁基氢化铝体系中,用 二氯甲烷,水,甲苯,叔丁醇 作为反应溶剂,化学反应 8.0H,反应生成 2,6-二氯-4-甲基-3-吡啶甲酸
参考文献:稳定的邻醌10-π电子系统furo的合成与反应
标题:稳定的邻醌10-π电子系统furo的合成与反应
摘要:4,6-二氯-3-(二乙基氨基)呋喃[3,4-C]吡啶-1-甲酸甲酯(6),是rama(II)催化的重氮分子内分子反应的reaction口-伊巴达反应中间体具有相邻酰胺基的羰基的基团已经被分离和表征.pm3的计算表明,这种非常稳定的分子的形成热(deltah(f))为-77.7 Kcal / Mol.化合物6与各种亲二烯体进行容易的diels-Alder环加成反应,从而通过最初形成的环加合物的开环得到多取代的异喹啉衍生物.在每种情况下,环加成都以高区域选择性进行,其中吸电子基团位于氨基的邻位.最有利的fmo相互作用是在氮杂异苯并呋喃6的homo和亲双烯体的lumo之间.
DOI:10.1021/jo991886W

专利信息

专利号:US-12172982-B2
优先权日:2020-08-12
标 题:Synthesis of quinazoline compounds
发明人：LIM NGIAP-KIE; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BIGLER RAPHAEL; CLAGG KYLE BRADLEY PASCUAL; DIPASQUALE ANTONIO GIOVANNI; GOSSELIN FRANCIS; ORCEL UGO JONATHAN; MEIER ROLAND CHRISTOPH
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are methods of synthesizing quinazoline compounds comprising at least one atropisomeric center.

专利号:US-12071422-B2
优先权日:2022-02-07
标 题 :Process for synthesis of quinazoline compounds
发明人：LEBL RENE; LIM NGIAP KIE; MEIER ROLAND CHRISTOPH; ORCEL UGO JONATHAN; SEDELMEIER JOERG; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BASS THOMAS MICHAEL; BIGLER RAPHAEL; BURKHARD JOHANNES ADRIAN; CLAGG KYLE BRADLEY PASCUAL; GOSSELIN FRANCIS; HAN CHONG; KALDRE DAINIS; KELLY SEAN M; HEROLD SEBASTIAN; LEITNER CHRISTIAN
权利人:GENENTECH INC; HOFFMANN LA ROCHE
摘要:Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

专利号:WO-2022035790-A1
优先权日:2020-08-12
标题:Synthesis of quinazoline compounds

专利号:EP-4196470-A1
优先权日:2020-08-12
标 题:Synthesis of quinazoline compounds

专利号:TW-202423916-A
优先权日:2020-08-12
标题 :Synthesis of quinazoline compounds

专利号:TW-I829003-B
优先权日:2020-08-12
标 题 :Synthesis of quinazoline compounds