CAS: 6873-09-2; 8,9-Dimethoxy-11,12-Dihydro-[1,3]Dioxolo[4,5-H]Isoquinolino[2,1-B]Isoquinolin-13-Ium

上下游产品

8-oxo-epiberberine dihydroepiberberine 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 5-bromo-benzo[1,3]dioxole-4-carbaldehyde

8-氧代-表小檗碱置于aluminum (Iii) Chloride,Lithium Aluminium Tetrahydride,碘,Potassium Acetate体系中,用 乙醚,乙醇 作为反应溶剂,化学反应 2.0H,反应生成 表小檗碱
参考文献:一种通用,简洁的策略,可以在四到八步之内集体合成50多种原小ber碱和5种金刚烷烷生物碱
标题:一种通用,简洁的策略,可以在四到八步之内集体合成50多种原小ber碱和5种金刚烷烷生物碱
摘要:报告了一种简洁,催化和通用的策略,该策略允许在四个步骤中为每个分子高效地合成22种天然13-甲基原小ber碱.该合成代表了迄今为止最有效,最短的路线,具有三个催化过程:Cui催化的氧化还原a 3反应,Pd催化的还原碳环化和pto 2催化的氢化.重要的是,这种针对四环框架的新策略也已应用于30多种天然原小ber碱(无13-甲基)和5种金刚烷烷生物碱的集体简明合成中.
DOI:10.1002/chem.201601245

专利信息

专利号:CN-112851661-A
优先权日:2021-01-08
标 题:A method for the modular and diverse synthesis of triphenanthridine and protoberberine alkaloids

专利号:US-2011086872-A1
优先权日:2002-05-03
标题 :Berberine as a selective lung cancer agent and other compositions and methods
发明人：TIN-WA MAUNG
权利人:TIN-WA MAUNG
摘要:Berberine or its salts or derivatives are identified as the active compound for selectively inhibiting lung cancer, potentially without toxic side effects. Berberine is preferably obtained by synthesis or partial synthesis, or is obtained from natural sources, such as Coptis teeta , or other berberine containing plants. Berberine and its derivatives are also active against HIV, and may be a safe new drug for the prevention of AIDS, alone or in combination with other antiviral agents. Composition and method of inhibiting tumor or viral infections and malaria without toxic side effects. A natural composition from the rhizome of Coptis teeta may be used as a safe new drug for the prevention of human breast cancer.