二乙醇胺置于氨,氢气体系中,化学反应生成羟乙基乙二胺 参考文献: Reductive Amination Of Diethanolamine And Resulting Product Mixture[fr] Amination Réductrice De Diéthanolamine Et Mélange De Produits Résultant 标题: Reductive Amination Of Diethanolamine And Resulting Product Mixture[fr] Amination Réductrice De Diéthanolamine Et Mélange De Produits Résultant 摘要:该发明提供了一种将二乙醇胺还原胺化制备成含有哌嗪(pip)和氨基乙基乙醇胺(aeea)的产品组合的方法.在该反应中使用具有过渡氧化铝/第二金属氧化物支撑和混合催化金属的催化剂,从而产生较低水平的非pip和非aeea副产物.
专利号:US-5618944-A 优先权日:1993-05-05 标题:Method for the synthesis of anthrapyrazolones 发明人:ZHANG LIN-HUA; AUERBACH JOSEPH 权利人:DU PONT MERCK PHARMA 摘要:This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphenyl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.
专利号:US-9440928-B2 优先权日:2011-07-20 标题 :Process for the synthesis of N-substituted cyclic alkylene ureas 发明人:GUPTA RAM; KOBYLANSKA IRINA; TREASURER URVEE; FLOOD LAWRENCE 权利人:GUPTA RAM; KOBYLANSKA IRINA; TREASURER URVEE; FLOOD LAWRENCE; ALLNEX IP S AR L 摘要:The invention relates to a process for the synthesis of N-substituted cyclic alkylene ureas by reacting a multifunctional aliphatic amine A having at least two amino groups which may be primary or secondary, at least one of which is a primary amino group, —NH 2 , and at least one of which is a secondary amino group, >NH, the other hydrogen group whereof having been substituted by a hydrocarbyl group which in turn may be substituted by a hydroxyl group, or an amino group, or a carboxyl group, or a ketone carbonyl group, or a hydrazide or hydrazone group, or a mercaptan group, and at least one further functional group selected from the group consisting of primary or secondary amino groups and hydroxyl groups, and an aliphatic organic carbonate component C selected from the group consisting of dialkyl carbonates CD and of alkylene carbonates CA.
专利号:US-5491245-A 优先权日:1993-03-26 标 题 :Method for the synthesis of amphoteric surfactants 发明人:GRUENING BURGHARD; WEITEMEYER CHRISTIAN 权利人:GOLDSCHMIDT AG TH 摘要:A method for the synthesis of amphoteric surfactants by the reaction of amines with chloroacetic acid or its salts in aqueous solution at an elevated temperature, consists of reacting compounds of the general formula ##STR1## with chloroacetic acid at temperatures ranging from 115° to 180° C., until the chloroacetic acid content is less than 10 ppm.
专利号:US-8907082-B2 优先权日:2010-07-06 标 题 :1,2-bis-(4,7-dimethyl-1,4,7-triazacyclonon-1-yl)-ethane and intermediate for the synthesis of same 发明人:HAGE RONALD; KOEK JEAN HYPOLITES; RUSSELL STEPHEN WILLIAM; VAN DER WOLF LODEWIJK; ZHANG JIANRONG; ZHAO WEI; WANG XIAOHONG 权利人:HAGE RONALD; KOEK JEAN HYPOLITES; RUSSELL STEPHEN WILLIAM; VAN DER WOLF LODEWIJK; ZHANG JIANRONG; ZHAO WEI; WANG XIAOHONG; CATEXEL LTD 摘要:The present invention provides improved processes for the synthesis of 1,4-ditosyl-1,4,7-triazacyclonone, comprising deprotecting a compound of formula (C): n nwherein P is tosylate or arylsulfonate, with an acidic medium to form 1,2-bis(1,4,7-triazacyclonon-1-yl)-ethane; and subsequently adding formaldehyde and formic acid to the acidic medium to form 1,2-bis-(4,7-dimethyl-1,4,7-triazacyclonon-1-yl)-ethane (Me 4 -DTNE). The syntheses of intermediates are also disclosed.
专利号:WO-9747313-A1 优先权日:1996-06-10 标题:Total synthesis of bacitracin polypetides 发明人:GRIFFIN JOHN H; MCDOUGAL PATRICK G 权利人:UNIV LELAND STANFORD JUNIOR 摘要:Methods for the total synthesis of bacitracin-type polypeptides are described, as well as useful analogs of bacitracin A, and treatment of bacterial infection using such analogs.
专利号:US-4709034-A 优先权日:1986-02-14 标 题 :Process for the synthesis of hydroxyalkyl amines and hydroxyalkyl piperazines 发明人:MARSELLA JOHN A 权利人:AIR PROD & CHEM 摘要:The present invention comprises a process for the synthesis of hydroxyalkyl amines, hydroxyalkyl piperazines, or alkyl piperazines from alkylene glycols and ammonia or alkyl amines using a substantially soluble transition metal carbonyl complex catalyst precursor.
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合成参考文献
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