CAS: 125697-92-9; 5-((2,5-Dihydroxybenzyl)(2-Hydroxybenzyl)Amino)-2-Hydroxybenzoic Acid

2,5-二羟基苯甲醛,5-氨基水杨酸,水杨醛 反应生成薰草菌素
参考文献:A Versatile Solid Phase Synthesis Of Lavendustin A And Certain Biologically Active Analogs
标题:A Versatile Solid Phase Synthesis Of Lavendustin A And Certain Biologically Active Analogs
摘要:Reaction Of Aminomethylated Polystyrene Resin (8) With Succinic Anhydride,Followed By Esterification Of The Free Carboxylic Acid Of The Product 9 With 2,5-Dihydroxybenzaldehyde (4) Afforded The Resin-Linked Aldehyde Intermediate 10. The Key Intermediate 10 Was Converted Into The Protein-Tyrosine Kinase Inhibitor Lavendustin A And Certain Analogs Through Reductive Amination And Reductive Alkylation Steps,Followed By Cleavage From The Resin. This Method Enables The Preparation Of A Wide Variety Of Lavendustin A Analogs Using Combinatorial Chemistry And Parallel Synthesis Techniques.
Doi:10.1021/jo961719L

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-12180228-B2
优先权日:2019-06-05
标题:Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
发明人：MOVASSAGHI MOHAMMAD; OLSSON CHASE ROBERT; SCOTT TONY Z; CHEAH JAIME; PAYETTE JOSHUA NATHANIEL
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The present disclosure provides, e.g., compounds, compositions, kits, methods of synthesis, and methods of use, involving epipolythiodiketopiperazines and polythiodiketopiperazines.

专利号:US-11759496-B2
优先权日:2016-05-10
标题:Compounds and pharmaceutical use thereof in the treatment of cancer
发明人：SUSIN SANTOS A; KAROYAN PHILIPPE; MERLE-BERAL HÉLÈNE
权利人:KAROYAN PHILIPPE
摘要:The present invention relates to a compound or a pharmaceutical salt thereof comprising a hexapeptide sequence of formula (I), its method of synthesis and its use in anticancer therapy. The invention also relates to a pharmaceutical composition for use in the treatment of cancer comprising at least one soluble peptide according to the invention or at least one acid nucleic according to the invention or at least one expression vector according to the invention, or at least one host cell according to the invention and a pharmaceutically acceptable carrier.

专利号:US-2009227575-A1
优先权日:2008-03-04
标 题 :7H-PYRROLO[2,3-H]QUINAZOLINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS
发明人：VENKATESAN ARANAPAKAM MUDUMBAI; CHEN ZECHENG; DOS SANTOS OSVALDO; BROOIJMANS NATASJA; GOPALSAMY ARIAMALA
权利人:WYETH CORP
摘要:A 7H-pyrrolo[2,3-h]quinazoline compound of the formula I n n n n n n n n n n wherein Ar, R 1 , R 2 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , and n are as defined in the specification, and methods for making same.

专利号:WO-2011059609-A9
优先权日:2009-10-13
标 题 :Dendrimer compositions and methods of synthesis

专利号:WO-2011028334-A2
优先权日:2009-08-26
标题:Synthesis and isolation of dendrimer systems