CAS: 2645-02-5; Tos-Gly-Ome

上下游产品

methanol N-Tosylglycine glycine ethyl ester hydr°Chloride p-toluenesulfonyl chlorideN-nitroso-N-(toluene-4-sulfonyl)-glycine methyl esterN-nitroso-N-(toluene-4-sulfonyl)-glycine methyl ester p-toluenesulfonylglycine isopropyl ester N-(toluene-4-sulfonyl)-glycine-(2-chloro-ethyl ester)N-(toluene-4-sulfonyl)-glycine-(2-chloro-ethyl ester) α-methoxy-N-(4-toluenesulphonyl)-glycine methyl ester

Sodium P-Toluenesulfonamide置于bis(Dibenzylideneacetone)-Palladium(0) Sodium Hydroxide,臭氧,三苯基膦体系中,用 四氢呋喃,二甲基亚砜 用作溶剂,化学反应 22.0H,反应生成对甲苯磺酰甘氨酸甲酯
参考文献:通过钯催化的烯丙基取代合成n-保护的氨基酯
标题:通过钯催化的烯丙基取代合成n-保护的氨基酯
摘要:N-保护的烯丙胺是通过钯催化的相应的乙酸烯丙酯的烯丙基取代为一系列的氮亲核试剂而制备的.将如此形成的n-保护的烯丙基胺进行烯烃的氧化裂解,得到n-保护的氨基酸或酯.
Doi:10.1016/0040-4039(93)88120-8

专利信息

专利号:US-4543422-A
优先权日:1982-10-26
标 题:Synthesis of vinyl esters
发明人：FARRAR DAVID
权利人:ALLIED COLLOIDS LTD
摘要:A vinyl ester of the formula R 3 COOR 4 where R 3 is CH 2 â•?CH-- or CH 2 â•?C.CH 3 -- and R 4 contains at least four carbon atoms and is selected from alkyl, cycloalkyl and aminoalkyl is conducted by reaction of an ester R 3 COOR 1 , where R 1 is C 1-3 alkyl, with metal alcoholate formed from an alcohol R 4 OH and titanium, aluminum, zirconium, calcium or magnesium in the absence of water or reactive alcohol.

专利号:US-4609755-A
优先权日:1983-10-20
标题 :Synthesis of vinyl esters
发明人：FARRAR DAVID
权利人:ALLIED COLLOIDS LTD
摘要:An ester interchange process, preferably for the formation of vinyl higher esters from methyl acrylate or methacrylate, is conducted in the presence of a novel alcoholate of the formula [M1(OR4)2-aRa6]x[M2(OR4)n-bRb6]y I wherein M1 is selected from Mg, Ca and Ba M2 is selected from Ti, Zr and Al n is 3 or 4 and is the valency of M2 a is a number from 0 to 1.5 b is a number from 0 to 0.75n x+Y=1 and each is a number from 0.005 to 0.995 and is such that the compound is liquid at 30 DEG 0 C. R4 is selected from alkyl having at least 4 carbon atoms, cycloalkyl having at least 4 carbon atoms and aminoalkyl, and each group R6 is individually selected from C1-3 alkoxy and blocking groups that are substantially less reactive in the ester interchange reaction than the groups OR4.

专利号:US-2007099915-A1
优先权日:2005-10-07
标题 :Inhibitors of the hiv integrase enzyme
发明人：DRESS KLAUS R; JOHNSON TED W; PLEWE MICHAEL B; TANIS STEVEN P; ZHU HUICHUN
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), n nand pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:US-2024018109-A1
优先权日:2020-06-19
标题 :Method for synthesis of roxadustat and intermediate thereof, and intermediate thereof

专利号:US-7468375-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人：DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:EP-1873155-A1
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人：DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; ZHU HUICHUN; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I),n nand pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus ('HIV') integrase enzyme.