CAS: 47355-10-2; Boc-Trp(For)-Oh

该化合物是氨酸锥体的一种衍生物,其特点是甲型氨基氨基乙基碳酸酯(Boc)保护组在α-氨基组中存在,而蛋白氮则存在一种形式基体.该化合物通常用于peptide合成,并作为中间体,用于制作更复杂的分子.Boc组在化学反应期间保护氨基组,允许有选择地修改其他功能组.形式类组引入反应性甲酰胺功能,可参与各种化学反应,包括凝聚和循环.该化合物在标准实验室条件下一般稳定,但可能对湿度和热度敏感.其溶解性通常在有机溶剂中,因此适合用于有机合成.与许多氨基酸衍生物一样,它可能展示生物活动,其衍生物可以探索潜在的制药用途.适当处理和储存条件对于保持其完整性和再活性至关重要.

结构式图片

相似化合物

143824-78-6 144599-95-1 163619-04-3

上下游产品

CAS号73-22-3 L-色氨酸 | CAS号23446-11-9 B°C-MET-GLY-TRP... | CAS号121062-08-6 美拉诺坦 II | CAS号137668-62-3 MSH (5-10), cyclic | CAS号74257-18-4 (2S)-2-amino-3-... | CAS号54-12-6 色氨酸

合成工艺路线路线简述

    二碳酸二叔丁酯,Nin-Formyl-L-Tryptophan置于三乙胺体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 48.0H,以61%的收率获得产物n-叔丁氧羰基-N'-醛基-L-色氨酸
    参考文献:Tert-Butoxycarbonylation Of Amino Acids And Their Derivatives: N-Tert-Butoxycarbonyl-L-Phenylalanine
    标题:Tert-Butoxycarbonylation Of Amino Acids And Their Derivatives: N-Tert-Butoxycarbonyl-L-Phenylalanine
    摘要:
    DOI:10.15227/orgsyn.063.0160

    海关参考信息

    专利信息


    专利号:US-2007179279-A1
    优先权日:2005-12-30
    标题:Methods for the synthesis of arginine-containing peptides
    发明人:CHEN LIN; ROBERTS CHRISTOPHER R
    权利人:CHEN LIN; ROBERTS CHRISTOPHER R
    摘要:Methods for the synthesis of arginine-containing peptides are provided. The methods include a step that minimizes contact of side chain protected arginine with base prior to the coupling step.

    专利号:US-7038037-B2
    优先权日:2002-06-20
    标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds
    发明人:MAIER MARTIN A; GUZAEV ANDREI P; MANOHARAN MUTHIAH
    权利人:ISIS PHARMACEUTICALS INC
    摘要:A sequential support-bound synthesis method is disclosed for preparing a conjugated oligomeric compound, preferably a PNA-peptide conjugate or an oligonucleotide-peptide conjugate, using a bridging molecule having at least two N-protecting amino groups. A conjugated oligomeric compound for therapeutic or prophylactic delivery is also disclosed.

    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-2004006203-A1
    优先权日:2002-06-20
    标题 :Method for sequential support-bound synthesis of conjugated oligomeric compounds

    专利号:EP-1968995-A1
    优先权日:2005-12-30
    标 题:Methods for the synthesis of arginine-containing peptides

    专利号:CN-102686601-A
    优先权日:2009-11-16
    标 题 :Synthesis of Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2
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    合成参考文献


    参考文献:10.1007/978-94-010-9060-5_39
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