CAS: 58194-26-6; Tetraethyl Ranelate

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ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl) thiophene-2-carboxylate ethyl bromoacetate diethyl 1,3-acetonedicarboxylate chloroacetic acid ethyl ester

1,3-丙酮二羧酸二乙酯置于吗啉,Adogen 464,Potassium Carbonate,Sulfur体系中,用 乙醇,丙酮 作为反应溶剂,化学反应 7.0H,反应生成 雷尼酸四乙酯
参考文献:取代噻吩并[2,3-Bpyrroles的合成
标题:取代噻吩并[2,3-Bpyrroles的合成
摘要:噻吩并[2,3-B]吡咯可以通过三个步骤合成:Gewald 合成,烷基化和 Thorpe-Ziegler 环化.3,6-双((乙氧羰基)甲基)-4-氨基-6H-噻吩并[2,3-B]吡咯-2,5-二羧酸二乙酯(13)已在dmf中通过一锅法以非常好的收率获得和高品质.© 2007 Wiley Periodicals,Inc. 杂原子化学 18:236-238,2007; 在线发表于 Wiley Interscience (Www.Interscience.Wiley.Com).doi 10.1002/hc.20290
DOI:10.1002/hc.20290

专利信息

专利号:US-8063100-B2
优先权日:2007-09-26
标 题 :Process for the synthesis of strontium ranelate and its hydrates
发明人：VAYSSE-LUDOT LUCILE; LECOUVE JEAN-PIERRE; LANGLOIS PASCAL
权利人:VAYSSE-LUDOT LUCILE; LECOUVE JEAN-PIERRE; LANGLOIS PASCAL; SERVIER LAB
摘要:A process for the industrial synthesis of strontium ranelate of formula (I): n nand its hydrates.

专利号:WO-2013113319-A1
优先权日:2012-01-31
标题 :Process for the preparation of strontium ranelate, intermediate or hydrates thereof
发明人：KOFTIS THEOCHARIS V; ROHIT RAVIKANT SONI; BHARAT BECHARBHAI BODA; DIPAKKUMAR NARSIBHAI BHUT; VIMALKUMAR SUBHIRBHAI PATEL
权利人:PHARMATHEN SA; KOFTIS THEOCHARIS V; ROHIT RAVIKANT SONI; BHARAT BECHARBHAI BODA; DIPAKKUMAR NARSIBHAI BHUT; VIMALKUMAR SUBHIRBHAI PATEL
摘要:The present invention relates to an improved process for the synthesis of strontium ranelate compound of formula I or its hydrates thereof. More particularly, the present invention relates to an economically viable and industrially feasible process for the preparation of strontium ranelate, intermediate or its hydrates thereof.

专利号:US-2009082578-A1
优先权日:2007-09-26
标题:Process for the synthesis of strontium ranelate and its hydrates