CAS: 6265-73-2; N-(2-Hydroxyethyl)Nicotinamide

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583-08-4 6265-73-2 349096-74-8

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CAS号59-67-6 烟酸 | CAS号141-43-5 2-氨基乙醇 | CAS号614-18-6 烟酸乙酯 | CAS号93-60-7 烟酸甲酯 | CAS号65141-46-0 尼可地尔 | CAS号56-23-5 四氯化碳 | CAS号72676-16-5 nicotinoyloxyet... | CAS号65141-46-0 尼可地尔 | CAS号83440-03-3 3-[(2-乙酰氧基)乙基氨基羰基]吡啶 | CAS号88354-02-3 2-(pyridine-3-c... | CAS号51991-23-2 N-(2-sulfanylet...

尼可地尔置于盐酸体系中,用 水 作为反应溶剂,化学反应 0.5H,反应生成 N-(2-羟乙基)烟酰胺
参考文献:分光光度法定量分析商业片剂中的尼可地尔
标题:分光光度法定量分析商业片剂中的尼可地尔
摘要:这项工作的主要目的是开发和验证用于测定商业片剂中尼可地尔的分光光度法.该方法是基于nh 4 Cl和zn粉尘将尼可地尔的硝氧基乙基还原为羰基化合物和亚硝酸根离子.由此形成的亚硝酸根离子与碘化钾和淀粉在稀盐酸介质中反应形成蓝色产物,该产物在 550 Nm 处最大吸收.在 0.4-4.0 μg Ml-1 的浓度范围内遵循比尔定律,摩尔吸收率为 7.92 X 10 4 L Mol-1 Cm-1 .检测限为0.017 μg Ml-1 .根据国际协调会议指南(美国)对反应条件进行优化和验证.该方法已成功应用于商业片剂中尼可地尔的测定.
DOI:10.1002/jccs.200800204

专利信息

专利号:US-4436912-A
优先权日:1981-09-08
标题:7-[2-(2-Aminooxazol-4-yl)-2-(oximino)acetamido cephalosporin antibiotics and intermediates therefor
发明人：WHEELER WILLIAM J
权利人:LILLY CO ELI
摘要:Cephalosporin broad spectrum antibiotics possessing a 7 beta -[2-[(2-aminooxazol)-4-yl]-2-(substituted oximino]acetamido side chain and a variety of substituents at the 3-position of the cephalosporins are claimed. Also claimed are intermediates in the synthesis of the above cephalosporin antibiotics.

专利号:US-4430499-A
优先权日:1981-09-08
标题:7-[2-(2-Aminooxazol-4-yl)-2-(oximino)acetamido]cephalosporin antibiotics
发明人：WHEELER WILLIAM J
权利人:LILLY CO ELI
摘要:Cephalosporin broad spectrum antibiotics possessing a 7 beta -[2-[(2-aminooxazol)-4-yl]-2-(substituted oximino)acetamido side chain and a variety of substituents at the 3-position of the cephalosporins are claimed. Also claimed are intermediates in the synthesis of the above cephalosorin antibiotics.

专利号:RU-2125040-C1
优先权日:1997-04-23
标 题:Succinic acid derivatives, method of preparing same, intermediate compounds for synthesis thereof, and method of preparing intermediate compounds

专利号:CN-115745879-A
优先权日:2022-11-16
标题:Synthesis method of nicorandil, nicorandil for injection and preparation method thereof

专利号:CN-114621138-B
优先权日:2020-12-10
标题:Nicorandil Synthesis method of trimer