CAS: 6832-87-7; 2-Bromo-N-Methylaniline

上下游产品

CAS号615-36-1 2-溴苯胺 | CAS号74-88-4 碘甲烷 | CAS号100-61-8 N-甲基苯胺 | CAS号106-95-6 烯丙基溴 | CAS号61783-59-3 3-[(2-bromoanil... | CAS号126799-87-9 1-(azidomethyl)... | CAS号4001-73-4 2-溴苯甲酰胺 | CAS号77-78-1 硫酸二甲酯 | CAS号344746-77-6 2-bromo-N-methy... | CAS号10113-38-9 N-4-(溴苯基)甲酰胺 | CAS号3558-24-5 N-甲基-2-苯基吲哚 | CAS号875-79-6 1,2-二甲基吲哚 | CAS号579-10-2 N-甲基乙酰苯胺 | CAS号17583-40-3 2-(甲基氨基)苯甲腈 | CAS号67932-23-4 4-bromo-3-methy... | CAS号88127-64-4 2-bromo-N-methy... | CAS号88127-66-6 N-(2-bromopheny... | CAS号5339-28-6 2-ethenyl-N-met...

N-甲基-N-亚硝基苯胺置于n-溴代丁二酰亚胺(Nbs),Silver Hexafluoroantimonate,Dichloro(Pentamethylcyclopentadienyl)Rhodium (Iii) Dimer,盐酸,Tin(II) Chloride Dihdyrate体系中,用 水,叔丁醇,甲醇 作为反应溶剂,化学反应 13.0H,以72%的收率获得产物2-溴-N-甲基苯胺
参考文献:Cp * Rh(iii)通过溶剂控制的区域选择性c-h官能化催化n-亚硝基苯胺的邻位卤化†
标题:Cp * Rh(iii)通过溶剂控制的区域选择性c-h官能化催化n-亚硝基苯胺的邻位卤化†
摘要:我们提出了一种新颖,有效和区域选择性的方法,用于铑催化苯胺的直接c-h邻位卤化反应,其中涉及可移动的n-亚硝基导向基团.该方法反应条件温和,底物范围宽,官能团耐受性好,收率令人满意.为了维持高邻位选择性和转化率,增加溶剂的空间位阻是至关重要的.初期机理研究表明,C-h活化可能参与速率测定步骤.
DOI:10.1039/c8Ob00601F

专利信息

专利号:US-6774125-B2
优先权日:1998-06-22
标 题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6696438-B2
优先权日:1998-06-22
标题:Cyclic amino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; DRESSMAN BRUCE A; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6838455-B2
优先权日:1998-06-22
标题 :Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6479668-B1
优先权日:1998-09-08
标 题 :Method of producing pyrrolidine derivatives
发明人：MURAOKA HIDEO; SATO HARUYO
权利人:TORAY INDUSTRIES
摘要:A method for producing pyrrolidine derivatives such as 3,4-epoxypyrrolodines, 3-pyrrolidols and the like, by oxidizing 3-pyrrolines with at least one peroxide in the presence of at least one acid is disclosed. The 3-pyrrolines are produced by deriving cis-2-butene compounds from cis-2-butene-1,4-diols and performing a cyclization between the cis-2-butene derivatives and at least one primary amine. The method may be performed as a one-pot synthesis and may be performed as a continuous reaction.

专利号:US-2003149022-A1
优先权日:1998-06-22
标 题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

专利号:US-2003153550-A1
优先权日:1998-06-22
标 题 :Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds