专利号:US-7358382-B2 优先权日:2001-08-03 标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production 发明人:WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN 权利人:BAYER SCHERING PHARMA AG 摘要:The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothilone derivatives.
专利号:US-8008526-B2 优先权日:2005-03-17 标 题 :Synthesis reaction catalyst and method of synthesizing compound using the same 发明人:TANAKA HIROHISA; KANEKO KIMIYOSHI 权利人:DAIHATSU MOTOR CO LTD; HOKKO CHEM IND CO 摘要:To improve a catalytic activity of a composite oxide, to carry out a reaction in a high yield, and to provide a synthesis reaction catalyst having excellent handling properties and a method of a synthesizing a compound using the same, a synthesis reaction catalyst containing a palladium-containing perovskite-type composite oxide having a specific surface area of 0.5 to 9.5 m 2 /g is used in Suzuki Cross-Couplings given by the following general scheme (14).
专利号:EP-1412323-B1 优先权日:2001-08-03 标 题:Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and derivatives and method for the production and use thereof
专利号:US-7592473-B2 优先权日:2005-03-17 标题:Method of synthesizing compound 发明人:TANAKA HIROHISA; KANEKO KIMIYOSHI 权利人:DAIHATSU MOTOR CO LTD; HOKKO CHEM IND CO 摘要:In order to provide a method of synthesizing a compound in which activity of a catalyst is maintained even when the catalyst is recovered after the completion of the coupling reaction using a palladium-containing perovskite-type composite oxide as the catalyst and used repeatedly and the reaction can be carried out in a high yield, a palladium-containing perovskite-type composite oxide is used as a synthesis reaction catalyst and a reaction solvent containing an alkoxy alcohol is used as a reaction solvent in Suzuki Cross-Couplings given by the following general formula (15).
专利号:US-2009023943-A1 优先权日:2005-03-17 标题 :Synthesis Reaction Catalyst and Method of Synthesizing Compound Using the Same
专利号:US-7863465-B2 优先权日:2006-04-03 标 题 :Antifungal agents 发明人:BALKOVEC JAMES M; BOUFFARD FRANCES AILEEN; TSE BRUNO; DROPINSKI JAMES; MENG DONGFANG; GREENLEE MARK L; PEEL MICHAEL; FAN WEIMING; MAMAI AHMED; LIU HAO; LI KEQAING 权利人:MERCK SHARP & DOHME; SCYNEXIS INC 摘要:The present invention relates to novel enfumafungin derivatives of formula I and pharmaceutically acceptable salts thereof, their synthesis, and their use as inhibitors of (1,3)-β-D-glucan synthase. The present compounds and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the present compounds and pharmaceutically acceptable salts thereof, are useful for treating or preventing antifungal infections and associated diseases and conditions.
摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 28. 摘要:P. Rumpf and R. La Riviere, C. R. Acad. Sci., Ser. C 244, 902 (1957). 摘要:H. Koshimura and T. Okubo, Anal. Chim. Acta 49, 67 (1970). 摘要:M. Laloi-Diard and P. Rumpf, Bull. Soc. Chim. Fr. 1961, 1645. 摘要:Kwiecień, H. U., Science of Synthesis: Knowledge Updates, (2024) 3, 46.