CAS: 90-80-2; (3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-One

• 英文名称(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-One
• 中文名称D-(+)-葡萄糖酸δ-内酯
• IUPAC名称(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-one
• 其它别名1,5-D-Gluconolactone; D-(+)-Gluconic Acid D-Lactone; D-(+)-Gluconic Acid-Delta Lactone; D-Gluconic Acid Lactone; Delta-Gluconic Acid Lactone; Unii-Wq29Kq9Pot; Delta-Gluconic Acid-Delta-Lactone; Glucolactone
• CAS编号90-80-2
• MFCD编号:MFCD00006647
• EINECS号:202-016-5
• 分子式:C6H10O6
• 分子量:178.14
• 产品CID: 1941718
• 产品分类生物化工 → 糖类化合物 → 单糖

• 相似结构搜索
• InChIKey: PHOQVHQSTUBQQK-SQOUGZDYSA-N
• InChI=1S/C6H10O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-5,7-10H,1H2/t2-,3-,4+,5-/m1/s1…
• 计算化学: 氢键受体数6.0氢键供体数4.0可旋转键数1.0

物理性质

• 熔点151-155 °C
• 沸点230.35 °C
• 闪点192.3±20.3 °C
• 密度0.6
• PH:65 º (c=1,H2O)
• pKa:12.06±0.60(预测)
• PSA:107.22
• LogP:-2.38
• 旋光度65º(C=1,H2O)
• 折射率1.608
• 蒸汽压0.0±2.4 mmHg at 25°C
• 溶解性590G/l Hydrolysis
• 敏感性本品无毒。１９３３年，美国ＦＤＡ已批准为无毒性食品添加剂。
• 外观形态白色至类白色结晶粉末
• 储存条件密封, 常温干燥保存
• 产品应用用作豆腐凝固剂,调味剂,pH降低剂及膨松剂的原料.在日本,作豆腐凝固剂占日本总用量的50-70,用该品制作豆腐,质地纯良,嫩滑可口,并可延长保存时间.我国食品添加剂使用卫生标准(GB2760-86)规定最大使用量为3.0g/kg.葡萄糖酸内酯在牛奶工业中用来防止乳石的生成,酿造工业中作啤酒石的防止剂,加入牙膏中有助于清除牙垢,此外还用于畜肉,金属表面处理剂等.
• 性质描述白色结晶粉末,无臭或略带气味.熔点117.8°C,相对密度1.760.易溶于水,并缓慢水解,在水中溶解度为59g/100ml,稍溶于乙醇,在乙醇中为1g/100ml,不溶于乙醚.新配制的1溶液pH为2.5.在水溶液中水解形成葡萄糖酸与其内酯的平衡溶液.

MSDS等安全信息

• GHS符号GHS07
• 危险类别严重眼刺激 类别2A
• 警示词Warning
• 危险描述H319 |造成严重眼刺激.
• 防范说明P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• UN编号NONH for all modes of transport
• 危险品标志Xn,Xi
• 安全声明24/25-53-36/37-26-25
• 危险类别码21-36/38-46-62-63
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 D-(+)-Glucono-1,5-Lactone 主要起始原料 D-Glucose
• 50-99-7 = 90-80-2
  反应条件:1.1 Reagents: Naphthalene Solvents: Cyclohexanone; 45 °C; 16 H,45 °C1.2 Solvents: Acetone
  标题:δ-Galactonolactone: Synthesis,Isolation,And Comparative Structure And Stability Analysis Of An Elusive Sugar Derivative
  作者:Bierenstiel,Matthias; Schlaf,Marcel
  参考文献:European Journal Of Organic Chemistry 日期:2004 卷标:(7) 页码:1474-1481]
  
  526-95-4 = 90-80-2 + 1198-69-2
  反应条件:1.1R:48 H,120°C
  标题:Synthesis Of Modified Lignin As An Antiplasticizer For Strengthening Poly(Vinyl Alcohol)-Lignin Interactions Toward Quality Gel-Spun Fibers
  作者:By Lin,Jiaxian Et Al
  参考文献:Acs Applied Polymer Materials 日期:2022 卷标:4(3) 页码:1595-1607]
  
  50-99-7 = 90-80-2
  反应条件:1.1R:
  标题:A Novel Biosensor With The Use Of Polypyrrole-Poly(Sodium-4-Styrenesulphonate) As A Dopant In The Determination Of Glucose
  作者:By Cete,Servet Et Al
  参考文献:Chemical Papers 日期:2020 卷标:74(3) 页码:799-808]
  
  492-61-5 = 90-80-2
  反应条件:1.1R:O2
  标题:Proton-Elisa: Electrochemical Immunoassay On A Dual-Gated Isfet Array
  作者:By Juang,Duane S. Et Al
  参考文献:Biosensors & Bioelectronics 日期:2018 卷标:117 页码:175-182]
  
  492-61-5 = 90-80-2
  反应条件:1.1R:O2,C:9001-37-0
  标题:Covalent Attachment Of Enzymes To Paper Fibers For Paper-Based Analytical Devices
  作者:By Boehm,Alexander Et Al
  参考文献:Frontiers In Chemistry (Lausanne 日期:2018 卷标:6 页码:214/1-214/10]
  
  57-50-1 = 90-80-2
  反应条件:1.1R:H2So4,S:H2O2.13.1R:H2So4,S:H2O
  标题:Potato Starch-Derived Almond-Shaped Carbon Nanoparticles For Non Enzymatic Detection Of Sucrose
  作者:By Das,Soma And Saha,Mitali
  参考文献:Xinxing Tan Cailiao 日期:2015 卷标:30(3) 页码:244-251]
  
  50-99-7 = 90-80-2
  反应条件:1.1C:75578-61-9,C:Carbon
  标题:Polymer-Based Conductive Nanocomposites For The Development Of Bioanodes Using Membrane-Bound Enzyme Systems Of Bacteria Gluconobacter Oxydans In Biofuel Cells
  作者:By Fedina,Veronika Et Al
  参考文献:Polymers (Basel 日期:2023 卷标:15(5) 页码:1296]
  
  50-99-7 = 90-80-2
  反应条件:1.1R:Naoh,C:Au,C:Cu2O,S:H2O
  标题:In-Situ Construction Of Au/cu2O Nanowire Arrays For Sensitive Glucose Sensing
  作者:By Wei,Chenhuinan Et Al
  参考文献:Talanta 日期:2023 卷标:254 页码:124194]
  
  90-80-2 + 1155-64-2 = 90-80-2
  反应条件:1.1S:Thf,Rt; 1 H,50°C2.1S:Dmf,36 H,Rt3.1R:Hbr,R:F3Cco2H,S:Acoh,1 H,0°C3.2R:Nahco3,S:H2O,Ph 73.3R:Et3N,S:Dmso,48 H,50°C
  标题:Biomimetic Glycopolypeptide Hydrogels With Tunable Adhesion And Microporous Structure For Fast Hemostasis And Highly Efficient Wound Healing
  作者:By Teng,Lin Et Al
  参考文献:Advanced Functional Materials 日期:2021 卷标:31(43) 页码:2105628]
  
  50-99-7 = 90-80-2
  反应条件:1.1R:Naoh,C:12016-86-3,S:H2O,15 D,Rt
  标题:A Highly Selective Enzyme-Free Amperometric Detection Of Glucose Using Perovskite-Type Lanthanum Cobaltite (Lacoo3)
  作者:By Tamilalagan,Elayappan Et Al
  参考文献:Journal Of The Electrochemical Society 日期:2021 卷标:168(8) 页码:086501]
  
  50-99-7 = 90-80-2
  反应条件:1.1R:O2,R:C:9001-37-0,C:Peroxidase,S:H2O,S:(Ch2Oh)2,Rt
  标题:Soft Magnetic Microrobot Doped With Porous Silica For Stability-Enhanced Multimodal Locomotion In A Nonideal Environment
  作者:By Li,Shangsong Et Al
  参考文献:Acs Applied Materials & Interfaces 日期:2022 卷标:14(8) 页码:10856-10874]
  
  50-99-7 = 90-80-2
  反应条件:1.1R:Codehydrase I,C:9028-53-9
  标题:A Coupled Enzymatic Reaction Of Tyrosinase And Glucose Dehydrogenase For The Production Of Hydroxytyrosol
  作者:By Deri-Zenaty,Batel Et Al
  参考文献:Applied Microbiology And Biotechnology 日期:2020 卷标:104(11) 页码:4945-4955]
  
  50-99-7 = 90-80-2 + 87-69-4 + 25525-21-7 + 20242-88-0 + 526-95-4 + 473-81-4 + 34685-57-9 + 3158-30-3 + 34685-56-8 + 79-14-1 + 6703-05-5 + 89299-64-9 + 13752-83-5 + 13280-76-7
  反应条件:1.1R:H2O2,C:Au,S:H2O,10 Min,120°C,5 Bar
  标题:Microwave-Assisted Base-Free Oxidation Of Glucose On Gold Nanoparticle Catalysts
  作者:By Rautiainen,Sari Et Al
  参考文献:Catalysis Communications 日期:2016 卷标:74 页码:115-118]
  
  299-28-5 = 90-80-2
  反应条件:1.1 Reagents: Oxalic Acid Solvents: Water1.2 Reagents: Ethanol Solvents: Water
  标题:Process For Preparation Of δ-Gluconolactone From Calcium Gluconate Using Microquantities Of A Solvent As Co-Inductor Of Crystallization
  参考文献:Brazil]
  
  526-95-4 = 90-80-2
  反应条件:1.1 Solvents: 1,4-Dioxane,Water; 1 Min,Heated; 1 Min,Heated
  标题:Maos Of D-Gluconic Acid,D-Glucono-1,4- And 1,5-Lactones,Esters,Hydrazides,And Benzimidazoles Thereof
  作者:El Ashry,E. S. H.; Awad,L. F.; Abdel Hamid,H.; Atta,A. I.
  参考文献:Journal Of Carbohydrate Chemistry 日期:2007 卷标:26 页码:329-338]
  
  = 90-80-2
  反应条件:1.1 Solvents: Water; < 45 °C
  标题:Synthesis Of D-Glucose Acid-δ-Lactone By Ultrasonic Method
  作者:Wang,Li-Yan; Fan,Lin-Lin; Sun,Zhu; Xing,Feng-Lan; Zhao,Bing
  参考文献:Huaxue Shijie 日期:2013 卷标:54(5) 页码:305-307]
  
  90-80-2 = 90-80-2
  反应条件:1.1 Reagents: Trifluoroacetic Acid,Hydrogen Bromide Solvents: Acetic Acid; 1 H,0 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Ph 71.3 Reagents: Triethylamine Solvents: Dimethyl Sulfoxide; 48 H,50 °C
  标题:Biomimetic Glycopolypeptide Hydrogels With Tunable Adhesion And Microporous Structure For Fast Hemostasis And Highly Efficient Wound Healing
  作者:Teng,Lin; Shao,Zhengwei; Bai,Qian; Zhang,Xueliang; He,Yu-Shi; Et Al
  参考文献:Advanced Functional Materials 日期:2021 卷标:31(43)

海关参考信息

• 2905122000-异丙醇
  2905310000-1,2-乙二醇
  2905320000-1,2-丙二醇
  2905399001-1,3-丙二醇
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

其他信息查阅

• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
• ➥ Globally Harmonized System
• ➥ REACH监管