CAS: 93778-57-5; 9-((2R,4S,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxytetrahydrofuran-2-yl)-9H-Purin-6-Ol

英文名称9-((2R,4S,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-4-Hydroxytetrahydrofuran-2-yl)-9H-Purin-6-Ol
中文名称5'-O-(4,4'-二甲氧基三苯甲基)-2'-脱氧肌苷
IUPAC名称9-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-ol
其它别名Dmt-Di; 5'-O-(4,4'-Dimethoxytrityl)-2'-Deoxyinosine; 5'-O-[bis(4-Methoxyphenyl)Phenylmethyl]-2'-Deoxyinosine; 2'-Deoxy-5'-O-Dmt
CAS编号93778-57-5
MFCD编号:MFCD00057879
EINECS号:298-195-2
分子式:C31H30N4O6
分子量:554.59
产品CID: 1979152
产品分类有机原料→生命科学→核苷&核苷酸→5’-保护核苷

相似结构搜索
InChIKey: IYNGMVFRUKBGNM-OYUWMTPXSA-N
InChI=1S/C31H30N4O6/c1-38-23-12-8-21(9-13-23)31(20-6-4-3-5-7-20,22-10-14-24(39-2)15-11-22)40-17-26-25(36)16-27(41-26)35-19-34-28-29(35)32-18…
计算化学: 氢键受体数9.0氢键供体数2.0可旋转键数9.0

相似化合物

119898-59-8 40094-22-2 68892-41-1

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H320-H335
防范说明P261-P280-P302+P352
危险品标志Xi

上下游产品

2-deoxyinosine 4,4'-dimethoxytrityl chloride (MeO)2Tr-OAc 4,4'-dimethoxytrityl alcohol Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester methyl ester Imidazole-1-carbothioic acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl] ester 5'-O-dimethoxytrityl-1-(2,4-dinitrophenyl)-2'-deoxyinosine 5'-O-dimethoxytrityl-1-amino-2'-deoxyinosine

合成工艺路线路线简述

890-38-0 + 40615-36-9 = 93778-57-5
反应条件:1.1 Solvents: Pyridine; > 12 H,Rt
标题:Process For Preparation Of 3'-Thiohypoxanthine Deoxyriboside Phosphoramidite Monomers And Application Thereof
参考文献:China]

890-38-0 + 40615-36-9 = 93778-57-5
反应条件:1.1 Reagents: 4-(Dimethylamino)Pyridine Solvents: Pyridine; Overnight,40 °C1.2 Reagents: Methanol
标题:Pro-Cyclic Dinucleotide Conjugates Comprising Sting Agonist For Cytokine Induction
参考文献:World Intellectual Property Organization]

= 93778-57-5 [标题:Reaction Conditions
标题:Synthesis And 1H And 13C Nmr Spectral Characteristics Of 8-Bromo-2',3'-Dideoxyguanosine And 8-Bromo-2',3'-Dideoxyinosine
作者:Zeidler,Joanna; Golankiewicz,Bozenna
参考文献:Nucleosides & Nucleotides 日期:1996 卷标:15(5) 页码:1077-1095]

= 93778-57-5 [标题:Reaction Conditions
标题:Nucleosides And Nucleotides. Part 75. Minor-Groove-Modified Oligonucleotides: Synthesis Of Decadeoxynucleotides Containing Hypoxanthine,N2-Methylguanine And 3-Deazadenine,And Their Interactions With Restriction Endonucleases Bgl Ii,Sau 3Ai,And Mbo I
作者:Ono,Akira; Ueda,Tohru
参考文献:Nucleic Acids Research 日期:1987 卷标:15(7) 页码:3059-72]

890-38-0 + 40615-36-9 = 93778-57-5
反应条件:1.1 Solvents: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene; Rt; 19 H,Rt
标题:Process For Preparation Of 3'-Thionucleosides
参考文献:China]

890-38-0 + 40615-36-9 = 93778-57-5
反应条件:1.1 Solvents: Pyridine; 19 H,Rt1.2 Solvents: Methanol; 5 Min,Rt
标题:A Simple Synthesis Of 2'-Deoxy-3'-Thioinosine And Its Phosphorothioamidite
作者:Luo,Qianfu; Cheng,Renjun; Wang,Qiu; Bao,Shuming
参考文献:Synthesis 日期:2013 卷标:45(1) 页码:106-110]

890-38-0 + 14874-70-5 + 14039-15-7 = 93778-57-5
反应条件:1.1 Reagents: Lithium Carbonate (Li2Co3),Diisopropylethylamine Solvents: Tetrahydrofuran; Heated1.2 30 Min,Rt; 2 H,Rt
标题:Improved Synthesis Of 5-Hydroxymethyl-2'-Deoxycytidine Phosphoramidite Using A 2'-Deoxyuridine To 2'-Deoxycytidine Conversion Without Temporary Protecting Groups
作者:Hansen,Anders S.; Thalhammer,Armin; El-Sagheer,Afaf H.; Brown,Tom; Schofield,Christopher J.
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2011 卷标:21(4) 页码:1181-1184]

= 93778-57-5 [标题:Reaction Conditions
标题:Phosphoramidites Of Base-Modified 2'-Deoxyinosine Isosteres And Solid-Phase Synthesis Of D(Gci*cgc) Oligomers Containing An Ambiguous Base
作者:Seela,Frank; Kaiser,Klaus
参考文献:Nucleic Acids Research 日期:1986 卷标:14(4) 页码:1825-44

二(4-甲氧基苯基)(苯基)甲醇置于tetrafluoroboric Acid,Lithium Carbonate,N,N-二异丙基乙胺体系中,用四氢呋喃,水作为反应溶剂,化学反应 0.67H,反应生成 5'-O-[双(4-甲氧基苯基)苯基甲基]-2'-脱氧肌苷
参考文献:使用无临时保护基团的 2'-脱氧尿苷向 2'-脱氧胞苷转化改进 5-羟甲基-2'-脱氧胞苷亚磷酰胺的合成
标题:使用无临时保护基团的 2'-脱氧尿苷向 2'-脱氧胞苷转化改进 5-羟甲基-2'-脱氧胞苷亚磷酰胺的合成
摘要:5-羟甲基胞嘧啶最近被定性为人类 Dna 中的"第六个碱基".为了能够对这种 Dna 修饰进行研究,我们报告了一种合成 5-羟甲基-2'-脱氧胞苷 (5-Home Dc) 亚磷酰胺的改进方法,用于位点特异性掺入寡核苷酸中.为了最大限度地减少操作,我们采用了一种利用相转移催化的临时无保护基团 2'-脱氧尿苷到 2'-脱氧胞苷的转化过程.所需的5-Home Dc 亚磷酰胺通过 6 个步骤从 2'-脱氧尿苷中获得,总产率为 24%.
DOI:10.1016/j.Bmcl.2010.12.098