CAS: 120202-66-6; Methyl (S)-2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-C]Pyridin-5(4H)-yl)Acetate Sulfate

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CAS号113665-84-2 氯吡格雷 | CAS号90055-48-4 (±)-盐酸氯吡格雷 | CAS号54903-50-3 4,5,6,7-四氢噻吩并[3... | CAS号1198409-05-0 (1R)-1-methyl-2... | CAS号1198409-07-2 (1R)-1-methyl-2... | CAS号120202-69-9 氯吡格雷杂质C | CAS号444891-19-4 BENZENEACETONIT... | CAS号444728-11-4 rac-2-(2-Chloro... | CAS号2856-63-5 邻氯苯乙腈 | CAS号113665-84-2 氯吡格雷 | CAS号144457-28-3 氯吡格雷羧酸

氯吡格雷置于硫酸体系中,用 水,丙酮 用作溶剂,化学反应 7.5H,以75%的收率获得硫酸氯吡格雷
参考文献:氯吡格雷硫酸氢盐的不对称合成
标题:氯吡格雷硫酸氢盐的不对称合成
摘要:摘要 通过应用以[(1S)-1-(4-甲氧基苯基)乙基]胺盐酸盐为手性助剂的strecker反应,开发了(S)-(+)-氯吡格雷硫酸氢盐的不对称合成.将2-氯苯甲醛加到氰化钠和[(1S)-1-(4-甲氧基苯基)乙基]胺盐酸盐的溶液中,得到非对映异构纯的(2S)-(2-氯苯基){[(1S)-1-(4-甲氧基苯基)乙基]氨基}乙腈盐酸盐.然后裂解手性助剂并伴随水解腈基团,得到对映体纯的(2S)-2-(2-氯苯基)甘氨酸盐酸盐,其为(S)-(+)-氯吡格雷的关键中间体. 通过应用以[(1S)-1-(4-甲氧基苯基)乙基]胺盐酸盐为手性助剂的strecker反应,开发了(S)-(+)-氯吡格雷硫酸氢盐的不对称合成.将2-氯苯甲醛加到氰化钠和[(1S)-1-(4-甲氧基苯基)乙基]胺盐酸盐的溶液中,得到非对映异构纯的(2S)-(2-氯苯基){[(1S)-1-(4-甲氧基苯基)乙基]氨基}乙腈盐酸
Doi:10.1055/s-0032-1316852

专利信息

专利号:US-8716507-B2
优先权日:2008-10-31
标题 :Iron(II) catalysts containing diimino-diphosphine tetradentate ligands and their synthesis
发明人：MIKHAILINE ALEXANDRE; FREUTEL FRIEDERIKE; SUI-SENG CHRISTINE; MEYER NILS; MORRIS ROBERT H; LAGADITIS PARASKEVI OLYMPIA
权利人:MIKHAILINE ALEXANDRE; FREUTEL FRIEDERIKE; SUI-SENG CHRISTINE; MEYER NILS; MORRIS ROBERT H; LAGADITIS PARASKEVI OLYMPIA; GOVERNING COUNCIL OF UNIVERSITY OF TORONTO
摘要:New hexa-coordinate iron (II) complexes comprising compounds of formula (I) are described. These compounds comprise a tetradentate ligand with donor atoms comprising nitrogen and phosphorus. These complexes are shown for the first time to be useful catalysts for the hydrogenation of ketones, aldehydes, or imines to produce alcohols or amines, and the asymmetric hydrogenation of prochiral ketones or imines to produce non-racemic alcohols or amines. The source of the hydrogen can be hydrogen gas or a hydrogen-donating molecule such as isopropanol or hydrogen-donating mixture such as formic acid and an amine depending on the structure of the catalyst. In certain embodiments, the axial ligands on the catalyst comprise organonitrile ligands, carbonyl ligands, isonitrile ligands, or combinations thereof. The catalysts and the preparation thereof are disclosed. A reaction using phosphine and diamine precursors that is templated by the iron ion is the preferred route to the catalysts.

专利号:WO-2017077550-A1
优先权日:2015-11-02
标题 :A metal free process for the preparation of alpha-substituted carbonyl compounds from alkenes
发明人：SUDALAI ARUMUGAM; PRASAD PRAGATI KISHORE; REDDI RAMBABU
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses a novel metal free process for the regioselective synthesis of α-substituted carbonyl compounds of formula I from alkene, X is selected from the following compounds (A, B).

专利号:US-2018148745-A1
优先权日:2015-05-26
标题:Hemoprotein catalysts for improved enantioselective enzymatic synthesis of ticagrelor
发明人：ARNOLD FRANCIS H; RENATA HANS; MCINTOSH JOHN A; LEWIS RUSSELL D; KAN SEK BIK JENNIFER; HERNANDEZ KARI; COELHO PEDRO; ROZZELL DAVID; ZHANG CHEN
权利人:CALIFORNIA INST OF TECHN; PROVIVI INC
摘要:The present invention provides methods by which trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine and related cyclopropane compounds are prepared using synthetic strategies that include a biocatalytic cyclopropanation step.

专利号:WO-2004074215-A1
优先权日:2003-02-03
标 题 :Process for preparation of clopidogrel, its salts and pharmaceutical compositions
发明人：NADKARNI SUNIL SADANAND; PATEL HASMUKH MATHURBHAI
权利人:NADKARNI SUNIL SADANAND; PATEL HASMUKH MATHURBHAI
摘要:The invention discloses an improved process for racemization of methyl (R)­(-) alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate , a stereoisomer formed in the synthesis of clopidogrel i.e. methyl (S)-(+)-alpha­ (2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate or its salts. The invention is also for an improved process for production of clopidogrel or its pharmaceutically acceptable salts. The invention further discloses novel clopidogrel salts and pharmaceutical compositions comprising them.

专利号:US-10888571-B2
优先权日:2015-12-18
标 题:Method and composition for increasing muscle protein synthesis and/or functional strength in mammals
发明人：BELLAMINE AOUATEF; ZHIVKOVICH ILYA; FREITAS ULLA
权利人:LONZA CONSUMER HEALTH INC
摘要:A method and composition for preserving muscle mass and function by increasing muscle protein synthesis and/or decreasing muscle protein degradation in mammals is disclosed. In one embodiment, the mammals are administered a protein building composition comprising at least two of an essential amino acid, an amino acid derivative, and a nitrogenous organic acid. In a particular embodiment, the protein building composition comprises leucine, L-carnitine, and creatine. The protein building composition can decrease TNF-α and increase mTOR expression in muscle.

专利号:CN-111699248-A
优先权日:2018-01-31
标题:Biocatalysts and methods for the synthesis of mixed disulfide conjugates of thienopyridine compounds