Ethyl 2-Hydroxy-2-(4-Phenoxyphenyl)Propionate置于溶剂黄146体系中,用 二氯甲烷,水 用作溶剂,化学反应 43.0H,反应生成恶唑菌酮 参考文献:Famoxadone: The Discovery And Optimisation Of A New Agricultural Fungicide 标题:Famoxadone: The Discovery And Optimisation Of A New Agricultural Fungicide 摘要:Famoxadone (3-Anilino-5-Methyl-5-(4-Phenoxyphenyl)-1,3-Oxazolidine-2,4-Dione),Is A New Agricultural Fungicide Recently Commercialized By Dupont Under The Trade Name Famoxate(R) Famoxadone Is A Member Of A New Class Of Oxazolidinone Fungicides That Demonstrate Excellent Control Of Plant Pathogens In The Ascomycete,Basidiomycete,And Oomycete Classes That Infect Grapes,Cereals,Tomatoes,Potatoes And Other Crops. Dupont'S Entry Into The Oxazolidinone Area Resulted From The Procurement Of 5-Methyl-5-Phenyl-3-Phenylamino-2-Thioxo-4-Oxazolidinone (1) From Professor Detlef Geffken,Then At The University Of Bonn,An Extensive Analog Program Was Initiated Immediately After The Fungicidal Activity Of 1 Was Discovered Through Routine Greenhouse Testing. The Discovery Program In The Oxazolidinone Area Eventually Culminated In The Advancement Of Famoxadone To Commercial Development In The Early 1990S. The Synthesis Of Various Oxazolidinone Ring Systems And The Development Of The Structure-Activity Relationships That Led To The Discovery Of Famoxadone Are Described. (C) 2001 Society Of Chemical Industry. Doi:10.1002/1526-4998(200102)57:2<143::Aid-Ps282>3.0.Co;2-8
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:US-2016073631-A1 优先权日:2013-03-04 标 题 :Process for the preparation of dihydropyrrole derivatives 发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS 权利人:SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD 摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) n n n n n n n n n n n n wherein n P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; n R 1 is chlorodifluoromethyl or trifluoromethyl; n R 2 is optionally substituted aryl or optionally substituted heteroaryl; n n is 0 or 1; n including the process comprising n (a-i) reacting a compound of formula II n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; n with nitromethane in the presence a chiral catalyst to give a compound of formula III n n n n n n n n n n n n n n n n wherein P, R 1 and R 2 are as defined for the compound of formula I; and n (a-ii) reductively cyclising the compound of formula III to give the compound of formula I. n n n n n The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).
专利号:US-9233920-B2 优先权日:2010-06-11 标题 :Process for the preparation of dihydropyrrole derivatives 发明人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS 权利人:EL QACEMI MYRIEM; SMITS HELMARS; CASSAYRE JEROME YVES; MULHOLLAND NICHOLAS PHILLIP; RENOLD PETER; GODINEAU EDOUARD; PITTERNA THOMAS; SYNGENTA PARTICIPATIONS AG; SYNGENTA LTD 摘要:The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered bicyclic heteroaryl group containing one or two nitrogen atoms as ring members, and wherein the phenyl, naphthyl and heteroaryl groups are optionally substituted; R 1 is chlorodifluoromethyl or trifluoromethyl; R 2 is optionally substituted aryl or optionally substituted heteroaryl; n is 0 or 1; including the process comprising (a-i) reacting a compound of formula II wherein P, R 1 and R 2 are as defined for the compound of formula I; with nitromethane in the presence a chiral catalyst to give a compound of formula III Wherein P, R 1 and R 2 are as defined for the compound of formula I; and (a-ii) reductively cyclizing the compound of formula III to give the compound of formula I. The invention also provides intermediates useful for processes for the synthesis of compounds of formula (I).
专利号:US-10906880-B2 优先权日:2016-01-26 标题:Kind of isothiazole oxime ether-containing strobilurin derivatives and its preparation methods and application 发明人:FAN ZHIJIN; CHEN LAI; GUO XIAOFENG; ZHU YUJIE; QIAN XIAOLIN; MA LIUYONG; ZHANG NAILOU; WANG HAIXIA; ZHANG ZHIMING; XU JINGHUA; SONG YINQI 权利人:UNIV NANKAI 摘要:The present invention is that provided a synthesis method of a series of isothiazole oxime ether containing strobilurin derivatives IV. The present invention relates to 3,4-dichloroisothiazolyl oxime ether strobilurin derivatives, and their chemical structural formula is as shown by IV. n n n n n n n n n n The invention discloses the structural formula of the above compound, the synthesis method and the use as an insecticide, a fungicide, an anti-plant virus agent, and an agriculturally acceptable auxiliary or synergist and a commercial insecticide. The use of a fungicide, an anti-plant virus agent and an acaricide in combination for controlling agricultural, forestry, horticultural plant pests, diseases, virus diseases and preparation methods.
专利号:US-9968097-B2 优先权日:2012-05-30 标题:Composition comprising a biological control agent and a fungicide selected from inhibitors of the lipid membrane synthesis, the melanine biosynthesis, the nucleic acid synthesis or the signal transduction 发明人:WACHENDORFF-NEUMANN ULRIKE; ANDERSCH WOLFRAM; STENZEL KLAUS; SPRINGER BERND 权利人:BAYER CROPSCIENCE AG 摘要:The present invention relates to a composition comprising at least one biological control agent. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.
专利号:US-2007232495-A1 优先权日:2006-03-24 标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof 发明人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L 权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L 摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.
1. López-Ruiz R, Romero-González R, Garrido Frenich A. Residues and dissipation kinetics of famoxadone and its metabolites in environmental water and soil samples under different conditions. Environ Pollut. 2019 Sep;252(Pt A):163-170. doi: 10.1016/j.envpol.2019.05.123. Epub 2019 May 23. 99(12):5368-5376. doi: 10.1002/jsfa.9794. Epub 2019 Jun 5.
合成参考文献
摘要:USEPA/Office of Pesticide Programs; Pesticide Fact Sheet- Famoxadone (July 2003). Available from, as of October 6, 2004: 摘要:Crop Protection Handbook 2004. (Formerly Farm and Chemicals Handbook) Willoughby, OH: Meister Publishing Co., 2004., p. C-221 摘要:Franke C et al; Chemosphere 29: 1501-14 (1994) 摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198 参考文献:10.1080/03601230600701726 摘要:CHRYSAYI-TOKOUSBALIDES M, KASTANIAS M, COWARD S, PHILIPPOUSSIS A, DIAMANTOPOULOU P. Residue Evaluation of Famoxadone and Trifloxystrobin in Cultivated Mushrooms. Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. 2006 Jun 01;41(5):571–83. doi: 10.1080/03601230600701726.