CAS: 13684-56-5; Desmedipham

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CAS号103-71-9 异氰酸苯酯 | CAS号7159-96-8 N-(3-羟苯基)氨基甲酸乙酯

3-氨基苯酚置于三乙胺体系中,用 四氢呋喃,苯 用作溶剂,化学反应 2.5H,反应生成甜菜安
参考文献:基于n-苯基氨基甲酸酯的新型胆碱酯酶抑制剂的合成和表征:抑制作用,抑制类型,亲脂性和分子对接的体外研究
标题:基于n-苯基氨基甲酸酯的新型胆碱酯酶抑制剂的合成和表征:抑制作用,抑制类型,亲脂性和分子对接的体外研究
摘要:基于阿尔茨海默氏病,其中使用氨基甲酸酯抑制剂利凡斯的明的目前的治疗,两个系列的氨基甲酸酯衍生物的已准备:(ⅰ)ñ用另外的氨基甲酸酯基(-Phenylcarbamates 1-12)和(II)ñ与单糖部分-Phenylcarbamates(13-24).测试了所有化合物对马血清中的胆碱酯酶,电鳗乙酰胆碱酯酶(eeache)和丁酰胆碱酯酶(eqbche)的抑制作用,并将抑制活性(表示为ic 50值)与既有药物加兰他敏和利瓦斯的明进行了比较. .具有两个氨基甲酸酯基团的化合物1-12与单糖衍生的氨基甲酸酯比较揭示在两个胆碱酯酶更高的抑制效率13-24并与rivastigmine一起使用.单糖脱缩醛化后,观测到对eqbche的抑制效率显着降低(对eeache也是有效的,但方式较少).此外,研究了五种所选化合物的抑制机理类型.已经发现,具有两个氨基甲酸酯基团的化合物大概是通过混合抑制机
Doi:10.1016/j.Bioorg.2018.03.012

专利信息

专利号:WO-2024256370-A1
优先权日:2023-06-13
标 题 :Synthesis of glufosinate using an amidase-based process
发明人：ZIMMERMANN GUNTHER; POTT MORITZ STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of preparing glufosinate, comprising the steps of hydrolysing an N-carbamoyl glufosinate amide with an Amidase enzyme to form an N- carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N- carbamoyl amino acid compound.

专利号:US-2025120400-A1
优先权日:2021-12-10
标题:Synthesis of glufosinate using a hydantoinase-based process
发明人：DITRICH KLAUS; BREUER MICHAEL; POTT MORITZ STEFAN; ZIMMERMANN GUNTHER; SEEMAYER STEFAN
权利人:BASF SE
摘要:The present invention relates to a method of manufacturing glufosinate, comprising the steps of hydrolysing a hydantoin with a Hydantoinase enzyme to form a N-carbamoyl amino acid compound followed by cleaving off the carbamoyl moiety of said N-carbamoyl amino acid compound.

专利号:US-11919928-B2
优先权日:2016-03-16
标题 :Method for producing dihydrotentoxin
发明人：KUBO TAKASHI; MACHIDA MASAYUKI; FUJIOKA TOMONORI; YAMAGUCHI Shigenari; KAWAI KIYOSHI
权利人:KUMIAI CHEMICAL INDUSTRY CO
摘要:An object of the present invention is to identify an enzyme having activity of synthesizing dihydrotentoxin that is a tentoxin precursor and an enzyme having activity of synthesizing tentoxin using dihydrotentoxin as a substrate. The present invention concerns a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 16 and having activity of nonribosomal peptide synthesis of dihydrotentoxin and a tentoxin synthesis-related gene encoding a protein comprising the amino acid sequence of SEQ ID NO: 18 and having activity of converting dihydrotentoxin to tentoxin.

专利号:US-2021386068-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and very long chain fatty acid (vlcfa) synthesis inhibitor herbicides
发明人：KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a VLCFA synthesis inhibitor herbicide. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof, and (b) a VLCFA synthesis inhibitor herbicide.

专利号:US-2021352899-A1
优先权日:2018-11-07
标题 :Compositions comprising pyridine carboxylate herbicides and fatty acid and lipid synthesis inhibitor herbicides
发明人：KISTER JEREMY; SATCHIVI NORBERT M
权利人:CORTEVA AGRISCIENCE LLC
摘要:Disclosed herein are compositions comprising (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof. Also disclosed herein are methods of controlling undesirable vegetation, comprising applying to vegetation or an area adjacent the vegetation or applying in soil or water to control the emergence or growth of vegetation (a) a pyridine carboxylate herbicide or an agriculturally acceptable N-oxide, salt, or ester thereof and (b) a fatty acid and lipid synthesis inhibitor (FA/LSI) herbicide, an agriculturally acceptable salt or ester thereof, or mixtures thereof.

专利号:ES-2717283-T3
优先权日:2012-07-24
标 题:Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and herbicides inhibitors of VLCFA synthesis and synthesis of fatty acids / lipids