CAS: 160232-08-6; Tert-Butyl ((2S,3R)-3-Hydroxy-4-(Isobutylamino)-1-Phenylbutan-2-yl)Carbamate

相似化合物

165727-45-7 1005324-40-2 853904-81-1

上下游产品

CAS号78-81-9 异丁胺 | CAS号98760-08-8 (2R,3S)-1,2-环氧-... | CAS号78-84-2 异丁醛 | CAS号165727-45-7 (3S)-3-(叔丁氧羰基)氨... | CAS号1229623-13-5 [N-(t-butoxycar... | CAS号193953-56-9 (4S,5S)-4-benzy... | CAS号244634-31-9 N-[(2R,3S)-3-氨基... | CAS号191226-98-9 [(1S,2R)-1-苄基-2... | CAS号635728-49-3 地瑞那韦乙醇盐 | CAS号183004-94-6 [(1S,2R)-1-苄基-2... | CAS号169280-56-2 4-氨基-N-[(2R, 3S... | CAS号160231-69-6 [(1S,2R)-3-[[(4...

异丁胺置于3S-(N-T-Butoxycarbonyl)Amino-2R-Hydroxy-4-Phenylbut-1-Yl Toluenesulfonate体系中,用 异丙醇,甲苯 用作溶剂,化学反应 1.5H,以76.8%的收率获得[(1S,2R)-2-羟基-3-[(2-甲基丙基)氨基]-1-(苯基甲基)丙基]-1,1,-二甲基乙酯
参考文献:Bis-Amino Acid Hydroxyethylamino Sulfonamide Retroviral Protease Inhibitors
标题:Bis-Amino Acid Hydroxyethylamino Sulfonamide Retroviral Protease Inhibitors
摘要:选定的双氨基酸羟乙基氨基磺胺化合物作为逆转录病毒蛋白酶抑制剂具有非常好的效果,特别是作为hiv蛋白酶的抑制剂.本发明涉及这类逆转录病毒蛋白酶抑制剂,更具体地涉及选定的新化合物,组合物和方法,用于抑制逆转录病毒蛋白酶,如人类免疫缺陷病毒(hiv)蛋白酶,预防逆转录病毒感染或传播,以及治疗逆转录病毒感染.

专利信息

专利号:US-6281367-B1
优先权日:1998-03-20
标 题:Process for the synthesis of HIV protease inhibitors
发明人：AL-FARHAN EMILE; DEININGER DAVID D; MCGHIE STEPHEN; O'CALLAGHAN JOHN; ROBERTSON MARK STUART; RODGERS KEITH; ROUT STEPHEN JOHN; SINGH HARDEW; TUNG ROGER DENNIS
权利人:GLAXO WELLCOME INC
摘要:An improved process for the synthesis of (3S)-tetrahydro-3-furyl N-[(1S,2R)-3 -(4-amino-N-isobutylbenzenesulphonamido)-1-benzyl-2-hydroxypropyl]carbamate comprising four steps form the compound of formula A and a novel intermediate thereto.

专利号:EP-0855388-B1
优先权日:1993-11-23
标 题 :Method for making intermediates useful in synthesis of retroviral protease inhibitors
发明人：NG JOHN S; PRZYBYLA CLAIRE A; MUELLER RICHARD A; VAZQUEZ MICHAEL L; GETMAN DANIEL P; FRESKOS JOHN J; DECRESCENZO GARY A; BERTENSHAW DEBORAH E; HEINTZ ROBERT M; ZHANG SUHONG; LIU CHIN; LANEMAN SCOTT A
权利人:SEARLE & CO
摘要:A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a cyanohydrin from a chiral alpha amino aldehyde.

专利号:US-6140505-A
优先权日:1995-03-10
标 题:Synthesis of benzo fused heterocyclic sulfonyl chlorides

专利号:US-5648511-A
优先权日:1990-11-19
标题 :Method for making intermediates useful in the synthesis of retroviral protease inhibitors

专利号:US-6127556-A
优先权日:1996-12-31
标 题 :Epoxide formation by continuous in-situ synthesis process
发明人：LIU CHIN; NG JOHN S; BEHLING JAMES R; CAMPBELL ARTHUR L
权利人:SEARLE & CO
摘要:In a method of preparing an aminoepoxide wherein a protected aminoaldehyde is reacted with a halomethyl organometallic reagent in an appropriate solvent at a temperature above -80° C., wherein said halomethyl organometallic reagent is formed by reaction between an organometallic reagent and a dihalomethane, the improvement comprising flowing said protected aminoaldehyde into a mixing zone maintained at a temperature below 0° C., also flowing said halomethyl organometallic reagent in said mixing zone for contacting in said mixing zone with said protected aminoaldehyde and also withdrawing from said mixing zone reaction products of said protected aminoaldehyde and said halomethyl organometallic reagent.

专利号:EP-1066276-A1
优先权日:1998-03-20
标题 :Process for the synthesis of hiv protease inhibitors