CAS: 2129-31-9; 4-(Diphenylphosphino)Benzoic Acid

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CAS号619-58-9 对碘苯甲酸 | CAS号829-85-6 二苯基膦 | CAS号5068-16-6 4-diphenylphosp... | CAS号124-38-9 二氧化碳 | CAS号734-59-8 二苯基(4-溴苯基)膦 | CAS号52509-80-5 p-F-C6H4COOK | CAS号5032-51-9 methyl 4-diphen... | CAS号17763-71-2 methyl 4-[(trif... | CAS号99-76-3 尼泊金甲酯 | CAS号3547-02-2 1,4-bis[2-(4-ni... | CAS号1437785-37-9 (2R)-°Ctyl 4-(d... | CAS号2272-04-0 4-diphenylphosp... | CAS号4233-13-0 [butyl(phenyl)p... | CAS号5032-51-9 methyl 4-diphen... | CAS号5068-15-5 4-diphenylphosp...

4-(Diphenylphosphoryl)Benzoic Acid置于草酰氯,氢气体系中,用 氘代氯仿 用作溶剂,130.0 °C,8.0 Mpa 条件下,反应 24.0H,以93%的收率获得4-二苯基膦苯甲酸
参考文献:使用草酰氯和氢气还原亲电性磷阳离子介导的氧化膦
标题:使用草酰氯和氢气还原亲电性磷阳离子介导的氧化膦
摘要:使用草酰氯作为活化剂,实现了以分子氢(h 2)对金属氧化物氧化物的无金属还原.量子力学研究支持通过原位形成的亲电phospho阳离子(epc)和氧化膦进行h 2的杂化裂解,以及随后的无阻转化为膦和hcl.该反应还可以通过由b(2,6-F 2 C 6 H 3)3和2,6-二甲基吡啶或氧化膦作为lewis碱组成的沮丧lewis对(flp)催化.三芳基和二芳基氧化膦证明了这种新颖的还原方法,提供了以非常好至极佳收率(51%至93%)的膦原子.
Doi:10.1002/anie.201809275

专利信息

专利号:US-8951728-B2
优先权日:2004-11-22
标 题:Template directed split and mix synthesis of small molecule libraries
发明人：RASMUSSEN PETER BIRK
权利人:CHEMGENE HOLDING APS
摘要:The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of: a) adding a linker molecule L to one or more reaction wells; b) adding a molecule fragment to each of said reaction wells; c) adding an oligonucleotide identifier to each of said reaction wells; d) subjecting said wells to conditions sufficient to allow said molecule fragments and said oligonucleotide identifiers to become attached to said linker molecule, or conditions sufficient for said molecule fragments to bind to other molecule fragments and sufficient for said oligonucleotide identifiers to bind to other oligonucleotide identifiers; e) combining the contents of said one or more reaction wells; and f) contacting the resulting bifunctional molecule(s) of step e) with one or more (oligonucleotide) templates each capable of hybridizing to at least one of the oligonucleotide identifiers added in step c).

专利号:US-8017323-B2
优先权日:2003-03-26
标 题 :Free reactant use in nucleic acid-templated synthesis
发明人：LIU DAVID R; SAKURAI KAORI
权利人:HARVARD COLLEGE
摘要:The present invention provides methods and compositions for expanding the scope of chemical reactions that can be performed during nucleic acid-templated organic syntheses. In particular, nucleic acid-templated chemistries are used to produce reaction intermediates attached to an oligonucleotide that can be used to identify the reaction intermediates and/or the resulting reaction products. The reaction intermediates then are reacted with free reactants (for example, reactants that are difficult or impractical to couple to an oligonucleotide) to produce a reaction product. This approach expands the scope of reagents useful in nucleic acid-templated syntheses to reagents that do not need to be or cannot be tethered to an oligonucleotide. The reagents, however, still permit the synthesis of reaction products attached to oligonucleotides that can be used to identify the reaction products.

专利号:US-9885035-B2
优先权日:2002-10-30
标 题 :Method for the synthesis of a bifunctional complex
发明人：FRANCH THOMAS; GOULIAEV ALEX HAAHR
权利人:NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:US-9422232-B2
优先权日:2009-07-09
标题:Reductive release probes containing a chemoselectively cleavable α-azidoether linker and methods of use thereof
发明人：FRANZINI RAPHAEL M; KOOL ERIC TODD
权利人:FRANZINI RAPHAEL M; KOOL ERIC TODD; UNIV LELAND STANFORD JUNIOR
摘要:Probes comprising one or more selectively cleavable α-azidoether moieties are provided; and linkers comprising the one or more selectively cleavable α-azidoether moieties. The α-azidoether moiety will undergo a Staudinger reaction with a suitable reducing agent, resulting in cleavage. The probes find use in a variety of detection assays, e.g. specific polynucleotide binding assays, polypeptide binding assays, etc. The cleavable linkers are suitable for synthetic reactions, e.g. to prepare probes of the invention; in the synthesis of cleavable peptide conjugates; and the like.

专利号:US-8293948-B2
优先权日:2006-03-24
标 题 :Reagent for organic synthesis and method of organic synthesis reaction with the reagent
发明人：CHIBA KAZUHIRO; KIM SHOKAKU; KONO YUSUKE
权利人:CHIBA KAZUHIRO; KIM SHOKAKU; KONO YUSUKE; JITSUBO CO LTD
摘要:A reagent for organic synthesis with which a chemical reaction can be conducted in a liquid phase and unnecessary compound(s) can be easily separated at low cost from the liquid phase after completion of the reaction. The reagent for organic synthesis reversibly changes from a liquid-phase state to a solid-phase state with changes in solution composition and/or solution temperature, and is for use in organic synthesis reactions. This reagent for organic syntheses facilitates process development. With the reagent, research on and development of, e.g., medicines through, e.g., compound library synthesis, etc. can be accelerated. It can hence contribute to technical innovations in the biochemical industry and chemical industry.