CAS: 2177-63-1; H-Asp(Obzl)-Oh

相似化合物

13188-89-1 3479-47-8 150009-58-8

上下游产品

CAS号56-84-8 L-天门冬氨酸 | CAS号100-51-6 苯甲醇 | CAS号2791-79-9 L-天冬氨酸二苄酯 | CAS号4427-49-0 Z(OMe)-Asp-(OBzl)-OH | CAS号7536-58-5 B°C-L-天冬氨酸 4-苄酯 | CAS号104-15-4 对甲苯磺酸 | CAS号2886-33-1 L-天冬氨酸双苄酯对甲苯磺酸盐 | CAS号3479-47-8 Cbz-L-天冬氨酸-4-苄酯 | CAS号100-39-0 溴化苄 | CAS号3479-47-8 Cbz-L-天冬氨酸-4-苄酯 | CAS号150009-58-8 N-Fm°C-D-天冬氨酸-4-苄酯 | CAS号94347-11-2 L-天门冬氨酸-4-苄酯叔丁酯盐酸盐 | CAS号51186-58-4 叔丁氧羰基-D-天冬氨酸 4-苄酯 | CAS号56-84-8 L-天门冬氨酸 | CAS号7536-58-5 B°C-L-天冬氨酸 4-苄酯 | CAS号86061-03-2 N-[(9H-芴-9-基甲氧基... | CAS号5513-72-4 for-asp(obzl)-oh

Boc-L-天冬氨酸 4-苄酯置于三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应 0.5H,反应生成L-天冬氨酸-4-苄酯
参考文献:N-吡咯烷基α/β肽结合了aboc(一种受约束的双环β氨基酸),用于不对称的羟醛反应催化
标题:N-吡咯烷基α/β肽结合了aboc(一种受约束的双环β氨基酸),用于不对称的羟醛反应催化
摘要:合成了一系列结合了约束的2-氨基双环[2.2.2]辛烷羧酸(aboc)残基的n-吡咯烷基α,β-肽催化剂,并在丙酮和一些对位取代的苯甲醛的不对称羟醛反应中进行了评估.结果表明,它们的催化性能高度依赖于氨基酸序列以及起决定性作用的aboc残基的绝对构型.在所测试的肽中,固态的转手构型的杂手性三肽h-Pro-(R)-Aboc-Asp-och 3 13被证明是最有效的催化剂,可高产率地提供β-羟基酮和非常好的对映选择性(高达87%).
Doi:10.1016/j.Tet.2016.02.027

专利信息

专利号:WO-0100609-A1
优先权日:1999-06-29
标题:Method for synthesis of n-homocysteine thiolactonyl retinamide
发明人：KAZIMIR MICHAEL; WILSON RAY E II
权利人:UNIV BAYLOR; KAZIMIR MICHAEL; WILSON RAY E II
摘要:The present invention describes methods of synthesis for N-homocysteine thiolactonyl retinamide (thioretinamide), a compound that has anticancer and antiatherogenic properties. The present invention further describes methods for the synthesis of N-homocysteine thiolactonyl retinamido cobalamin (thioretinaco), a compound that has potential anticancer, antineoplastic, antiviral, and antiatherogenic properties.

专利号:US-5124478-A
优先权日:1987-12-22
标 题:Acid-labile anchor groups for the synthesis of peptide amides by a solid-phase method
发明人：BREIPOHL GERHARD; KNOLLE JOCHEN; STUEBER WERNER
权利人:HOECHST AG
摘要:The invention relates to new compounds of the formula ##STR1## in which R 1 denotes (C 1 -C 8 )-alkyl, R 2 denotes an amino acid residue which is protected with a urethane protective group which can be eliminated with weak acid or base, or denotes an amino protective group which can be eliminated with weak acid or base, R 3 denotes hydrogen or (C 1 -C 4 )-alkyl, and Y 1 -Y 9 denote identical or different radicals hydrogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy or --O--(CH 2 ) n --COOH (with n=1 to 6), with one of these radicals being --O--(CH 2 ) n --COOH, or Y 1 , Y 2 and Y 5 -Y 9 denote identical or different radicals hydrogen, (C 1 -C 4 )-alkyl or (C 1 -C 4 )-alkoxy, Y 3 denotes hydrogen or (C 1 -C 8 )-alkoxy and Y 4 denotes --(CH 2 ) n --COOH or --NH--CO--(CH 2 ) n --COOH (with n=1 to 6). n Processes for the preparation thereof and the synthesis of peptide amides by a solid-phase method using these new compounds (spacers) are described.

专利号:US-4922015-A
优先权日:1987-04-08
标 题:Synthesis of peptide amides by means of a solid phase method using acid-labile anchoring groups
发明人：BREIPOHL GERHARD; KNOLLE JOCHEN; STUEBER WERNER
权利人:HOECHST AG
摘要:The invention relates to new compounds of the formula ##STR1## in which R 1 denotes (C 1 -C 8 )-alkyl or optionally substituted (C 6 -C 14 )-aryl, R 2 denotes hydrogen or an amino acid residue which is protected by an amino protective group which can be cleaved off with weak acid or base, R 3 denotes hydrogen or (C 1 -C 4 )-alkyl, and Y 1 -Y 9 denote identical or different radicals hydrogen, (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy or -O-(CH 2 ) n -COOH (with n=1 to 6), one of these radicals being -O-(CH 2 ) n -COOH. A process for the preparation thereof and the synthesis of peptide amides by means of a solid phase method using these new compounds (spacers) are described.

专利号:US-5565606-A
优先权日:1986-10-21
标 题:Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
发明人：BREIPHOL GERHARD; KNOLLE JOCHEN
权利人:HOECHST AG
摘要:The invention relates to compounds of the formula I in which A denotes hydrogen or an amino protective group, B denotes one or more amino acids, X denotes alkylene or aralkylene, Y1, Y2, Y3 and Y4 are identical or different and denote hydrogen, methyl, methoxy or nitro, V denotes hydrogen or a carboxyl protective group, W denotes -[CH2]n- or -O-[CH2]n-, m denotes 0 or 1, n denotes 0 to 6, and p denotes 0 to 5, to a process for their preparation. The compounds of formula I are useful as linkage agents or anchor groups in the solid-phase synthesis of peptide aminoalkylamides and peptide hydrazides.

专利号:US-6217857-B1
优先权日:1989-06-28
标题 :Cytokine synthesis inhibitory factor (IL-10) and pharmaceutical compositions thereof
发明人：MOSMANN TIMOTHY R; MOORE KEVIN W; BOND MARTHA W; VIEIRA PAULO J M
权利人:SCHERING CORP
摘要:Mammalian genes and proteins, designated cytokine synthesis inhibitory factors (CSIF's, now known as Interleukin-10 (IL-10)), are provided which are capable of inhibiting the synthesis of cytokines associated with delayed type hypersensitivity responses, and which, together with antagonists, are useful in treating diseases associated with cytokine imbalances, such as leishmaniasis and other parasitic infections, and certain immune disorders including MHC associated autoimmune diseases caused by excessive production of interferon-gamma.

专利号:US-5948693-A
优先权日:1994-09-01
标题:Solid phase synthesis of immunosuppressive agents
发明人：RICH DANIEL H; RAMAN PRAKASH; ANGELL YVONNE M
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The present invention relates generally to cyclosporin analogs, and more paritcularly to methods for the solid-phase synthesis and on-resin cyclization of cyclosporin analogs. Methods are described for the on-resin cyclization of sterically hindered compounds synthesized through solid phase synthesis techniques. The methods utilize solvent, temperature, and washing conditions that allow the efficient on-resin cyclization of compounds like analogs of cyclosporin A.