合成目标产物 1,2,4-Triazolo[4,3-A]Pyridin-3(2H)-One 主要起始原料 2-Hydrazinopyridine And Urea
(文献来源)合成步骤主要原料 2-Hydrazinopyridine 和 Urea
Dl-1,2-二苯基-1,2-乙二硫醇置于三氟甲磺酸体系中,用 甲苯 作为反应溶剂,化学反应 0.25H,以72%的收率获得产物吡啶三唑酮 参考文献:Microwave-Assisted N-Debenzylation Of Amides With Triflic Acid 标题:Microwave-Assisted N-Debenzylation Of Amides With Triflic Acid 摘要:A New And Facile Microwave-Assisted Protocol For The Debenzylation Of N-Benzylamides With Triflic Acid Has Been Developed. Both Secondary And Tertiary Aliphatic Or Aromatic Amides Are Obtained In Moderate To Good Yields. (C) 2010 Elsevier Ltd. All Rights Reserved. DOI:10.1016/j.Tetlet.2010.07.022
专利号:WO-2024015528-A1 优先权日:2022-07-15 标题 :Efficient procedure for the synthesis of hydrazone-linked tetrahedral nanocages 发明人:SCHNEEBELI SEVERIN; VESTRHEIM OLAV 权利人:UNIV VERMONT 摘要:The present application is directed to a nanocage of Formula (I): wherein A and R are as described herein. The present application is also directed to an efficient process for preparation of a nanocage of Formula (I), which allows for efficient scale-up of the nanocage synthesis. Furthermore, this new process allows for rapid nanocage diversification, due a newly introduced late-stage functionalization method.
专利号:US-9936723-B2 优先权日:2014-02-12 标题 :Process for the synthesis of substituted 1-benzyl-3-(1-(isoxazol-4-ylmethyl)-1h-pyrazol-4-yl)imidazolidine-2,4-diones 发明人:FOTSING JOSEPH R 权利人:SENOMYX INC 摘要:The present invention relates to processes and intermediates for the preparation of compounds of formula (I): n nor a salt or oxide thereof, wherein Alk, M1, M2, R1, R2, R3, R4, R5, R6, R7, and n are as described herein. The present invention also relates to compounds of formula (I) and composition comprising a compound of formula (I). Also disclosed is a method of altering or improving the taste of a composition that includes adding to the composition at least one compound of formula (I), in an amount effective to obtain a modified composition having altered or improved taste relative to an otherwise identical composition lacking said compound.
专利号:US-RE41998-E 优先权日:1990-02-26 标题 :Compositions and methods of treatment of sympathetically maintained pain 发明人:CAMPBELL JAMES N 权利人:ARCLON THERAPEUTICS INC 摘要:Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an α-1-adrenergic antagonist, α-2-adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic norepinephrine, known collectively as sympatholytic agents. Chemical formulas for several sympatholytic agents are given.
专利号:US-5010198-A 优先权日:1984-12-03 标题:Intermediates for the synthesis of benzoxazol- and benzothiazolamine derivatives, useful as anti-anoxic agents 发明人:STOKBROEKX RAYMOND A; LUYCKX MARCEL G M; JANSSENS FRANS E 权利人:JANSSEN PHARMACEUTICA NV 摘要:Benzoxazol- and benzothiazolamine derivatives having anti-anoxic properties which compounds are useful in the treatment of anoxia. These compounds are produced from certain benzoxazol- and benzothizolamine intermediates.
专利号:US-10968173-B2 优先权日:2016-07-07 标题:Thiocarbonylthio compounds as chain transfer agents suitable for raft polymerization 发明人:COCHRAN ERIC W; HERNANDEZ NACU; FORRESTER MICHAEL; HOHMANN AUSTIN 权利人:UNIV IOWA STATE RES FOUND INC 摘要:The present invention relates to a compound having the structure of formula (I), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as described herein. The present invention also relates to a process for the preparation of a compound of formula (I) and to a process for the synthesis of a polymer using the compound of formula (I) through controlled free radical polymerization.
专利号:US-2021403993-A1 优先权日:2020-06-30 标题 :Catalytically controlled sequencing by synthesis to produce scarless dna 发明人:PUGLIESE KAITLIN; PEISAJOVICH SERGIO; MANDELL JEFFREY; MCDONALD SETH 权利人:ILLUMINA INC 摘要:The present disclosure relates to methods comprising (a) contacting a polymerase with a template polynucleotide and a plurality of free nucleotides, wherein the template polynucleotide is hybridized to a complementary polynucleotide comprising a 3′ end overhung by a 5′ terminal fragment of the template polynucleotide, and the plurality of free nucleotides comprise a compound Formula (I); wherein said contacting occurs under a complexation condition, the complexation condition effective to form a complex but not effective to form polymerization, wherein the complex comprises the polymerase, the template polynucleotide, the complementary polynucleotide, and one of the plurality of free nucleotides that is complementary to a first nucleotide of the 5′ terminal fragment of the template polynucleotide; (b) detecting a signal from the fluorescent label; and (c) exposing the complex to a polymerization condition.