1-氨基环丙烷甲酸甲酯盐酸盐置于potassium Carbonate体系中,用 乙醚,水 作为反应溶剂,化学反应生成 1-氨基环丙基甲酸甲酯 参考文献:Decarboxylation Of 1-Aminocyclopropanecarboxylic Acid And Its Derivatives 标题:Decarboxylation Of 1-Aminocyclopropanecarboxylic Acid And Its Derivatives 摘要: DOI:10.1021/jo00269A013
专利号:US-9351954-B2 优先权日:2009-12-04 标 题:Multicyclic compounds and methods of use thereof 发明人:SHAO LIMING; CAMPBELL JOHN EMMERSON; HEWITT MICHAEL CHARLES; CAMPBELL UNA; HANANIA TALEEN G 权利人:SUNOVION PHARMACEUTICALS INC; PGI DRUG DISCOVERY LLC 摘要:Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. For example, disclosed herein are compounds having formula (IIa) shown below, or a pharmaceutically acceptable salt or stereoisomer thereof, wherein the variables are defined herein. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
专利号:US-8338565-B2 优先权日:2008-08-20 标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha 发明人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P 权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP 摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.
专利号:US-2008176865-A1 优先权日:2005-06-15 标 题:Substituted arylpyrazoles 发明人:BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL 权利人:PFIZER LTD 摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.
专利号:CN-104341450-A 优先权日:2013-08-09 标 题 :Synthesis and pharmaceutical application of a kind of sulfonamide derivative
参考文献:10.1007/s11627-023-10339-3 摘要:Li X, Fang P, Li M, Xu P. Identification of methyl 1-aminocyclopropanecarboxylate as a novel ethylene agonist: a structural analogy approach. In Vitro Cell.Dev.Biol.-Plant. 2023 Feb;59(1):61–73. doi: 10.1007/s11627-023-10339-3.