CAS: 107133-36-8; 2-Methylpropan-2-Amine (2S,3As,7As)-1-((S)-2-(((S)-1-Ethoxy-1-Oxopentan-2-yl)Amino)Propanoyl)Octahydro-1H-Indole-2-Carboxylate

上下游产品

Perindopril tert-butylaminetert-butylamine °Ctahydro-1H-indole-2-carboxylic acid (2S,3aS,7aS)-perhydroindole-2-carboxylic acidperindoprilat Perindopril ethyl (2S)-2-[(3S,5aS,9aS,10aS)-3-methyl-1,4-dioxo-5a,6,7,8,9,9a,10,10a-°Ctahydro-3H-pyrazino[1,2-a]indol-2-yl]pentanoate (2S,3aS,7aS)-1-[(S)-N-[(S)-1-carboxy-butyl]alanyl]hexahydro-2-indolinecarboxylic acid 1-ethyl ester para-toluenesulfonate

培哚普利置于叔丁胺体系中,用 乙酸乙酯 用作溶剂,化学反应 1.5H,以65%的收率获得培哚普利叔丁胺盐
参考文献:Process For The Preparation Of Perindopril
标题:Process For The Preparation Of Perindopril
摘要:提供了制备依那普利中间体的新方法.同时,还提供了改进的依那普利厄布明制备方法,包括(A)将式(15)化合物与硅烷基化的八氢吲哚-1H-2-羧酸反应以形成依那普利;以及(B)将依那普利与叔丁基胺反应以形成式i的依那普利厄布明.

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-7323575-B2
优先权日:2003-04-09
标题:Process for the synthesis of (2S)-indoline-2-carboxylic acid
发明人：SOUVIE JEAN-CLAUDE; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): n nApplication in the synthesis of perindopril and its pharmaceutically acceptable salts.

专利号:US-6774259-B2
优先权日:2000-04-11
标 题 :Method for synthesis of n-[(s)]-1-carboxybutyl-(s)-alanine esters and use in synthesis of perindopril
发明人：SOUVIE JEAN-CLAUDE; RENAUD ALAIN
权利人:SERVIER LAB
摘要:A stereoselective process for the industrial synthesis of compounds of formula (I):wherein R represents linear or branched (C1-C6)alkyl, andapplication in the synthesis of perindopril and pharmaceutically acceptable salts thereof.

专利号:US-6818788-B2
优先权日:2000-03-31
标 题:Method for synthesis of n-[(s)-1-carboxybutyl]-(s)-alanine esters and use in synthesis of perindopril
发明人：SOUVIE JEAN-CLAUDE
权利人:SERVIER LAB
摘要:Stereoselective process for the industrial synthesis of compounds of formula (I):wherein R represents linear or branched (C1-C6)alkyl.Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.

专利号:US-4902817-A
优先权日:1987-09-17
标 题 :Process for the synthesis of alpha n alkylated amino acids and esters thereof, application to the synthesis of carboxyalkyl dipeptides
发明人：VINCENT MICHEL; BALIARDA JEAN; MARCHAND BERNARD; REMOND GEORGES
权利人:ADIR
摘要:Stereoselective process for the industrial synthesis of compounds of formula (I): ##STR1## where R 1 is linear or branched lower alkyl with 1 to 6 carbon atoms, n R 2 is a linear or branched lower alkyl with 1 to 4 carbon atoms, n employing inexpensive starting materials and obtaining optimum yields. n Application to the synthesis of carboxyalkyl dipeptides.

专利号:US-7288661-B2
优先权日:2003-12-10
标 题 :Process for the synthesis of (2S,3aS,7aS)-1-[(S)-alanyl]-octahydro-1H-indole-2-carboxylic acid compounds and application in the synthesis of perindopril
发明人：DUBUFFET THIERRY; LECOUVE JEAN-PIERRE
权利人:SERVIER LAB
摘要:Process for the synthesis of compounds of formula (I): n nwherein R represents a hydrogen atom or a protecting group for the amino function.n n Application in the synthesis of perindopril and pharmaceutically acceptable salts thereof.