CAS: 198561-07-8; Fmoc-Pra-Oh

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220497-98-3 191215-87-9 63039-46-3

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CAS号23235-01-0 L-炔丙基甘氨酸 | CAS号102774-86-7 (9H-芴-9-基)甲基 2,... | CAS号82911-69-1 9-芴甲基-N-琥珀酰亚胺碳酸酯 | CAS号71460-15-6 (R)-2-氨基-4-戊炔酸叔丁酯 | CAS号326667-54-3 (S)-2-(benzhydr... | CAS号146549-21-5 Fm°C-L-烯丙基甘氨酸

Tert-Butyl (S)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)Pent-4-Ynoate置于三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应 15.0H,以99%的收率获得fmoc-L-炔丙基甘氨酸
参考文献:Dansylated Polytheonamide 模拟物的设计,合成和功能分析:一种人工肽离子通道
标题:Dansylated Polytheonamide 模拟物的设计,合成和功能分析:一种人工肽离子通道
摘要:我们在此报告了一种新型人工离子通道分子的设计,全合成和功能分析,称为丹磺酰化聚乙醇酰胺模拟物 (3).通道 3 的设计基于一种非常有效的细胞毒素,Polytheonamide B (1).我们开发合成离子通道的策略可以很容易地衍生出各种功能,涉及两个关键特征.首先,通过用市售氨基酸替换许多需要多步合成的非蛋白质氨基酸残基来简化 1 的结构,同时保留折叠所需的那些残基.它显着减少了合成步骤的数量,并促进了 3 的实用化学构建. 其次,在残基 44 处引入炔丙基甘氨酸使得能够轻松安装丹酰基作为 3 膜定位的报告基因.新设计的保护基策略的应用提供了通过一个自动固体有效构建残基 12-48 的 37 个氨基酸序列相肽合成.从树脂上裂解肽后,通过丹酰基引入和与残基 1-11 的一个片段偶联反应合成 3,然后进行全局脱保护.简化的模拟 3 对 P388 小鼠白血病细胞 (Ic(50) = 12 Nm)
Doi:10.1021/ja303831A

专利信息

专利号:US-2025069787-A1
优先权日:2021-11-25
标 题:Method for preparing acid resistant magnetic particles and acid resistant magnetic particles
发明人：SILVESTRE MARTIN EDUARDO; EISOLD SABINE; HEINDL DIETER; PETERS KRISTINA
权利人:ROCHE DIAGNOSTICS OPERATIONS INC
摘要:In a first aspect, the invention relates to a method for preparing a magnetic bead comprising at least one magnetic particle (M) and a silica coating, wherein the silica coating comprises at least two silica layers, the method comprising steps (a) to (d), wherein at least one of steps (b), (c) and (d) is/are done under sonication, wherein sonication is done with an amplitude (peak-to-peak) in the range of from 50 to 250 μm. A second aspect of the invention is related to a magnetic bead comprising (i) at least one magnetic particle (M) and (ii) a silica coating, wherein the silica coating comprises at least two silica layers; wherein the magnetic bead is stable against 7.5 M hydrochlorid acid and has a metal (cation) leaching rate in 7.5 M hydrochloric acid in the range of from 0.1 to 10%, wherein the metal (cation) leaching is determined according to a complex formation of Fe2+ with bathophenanthroline according to Reference Example 8.2. In a third aspect, the invention relates to a functionalized magnetic bead comprising at least one, magnetic bead according to the second aspect, wherein an outer silica layer is functionalized with at least one group selected from the group consisting of amino group, azide group, alkyne group, carboxyl group, thiol group, epoxy group, aryl group and alkyl group. A fourth aspect of the invention is directed to a process for functionalizing a magnetic bead according to the second aspect comprising at least one magnetic particle (M) and a silica coating, wherein the silica coating comprises at least two silica layers. A fifth aspect of the invention is related to a method for preparing magnetic Fe3O4 supra particles and a sixth aspect relates to the use of a magnetic bead according to the second aspect or of a functionalized according to the fourth aspect for immobilization of acid stable biocatalysts or for solid-phase organic synthesis using acid-stable linker.

专利号:US-10501496-B2
优先权日:2013-05-23
标 题 :Chemical synthesis and screening of bicyclic peptide libraries