欧盟法规
REACH注册ECHA物质C&L通报REACH预注册上下游产品
chloroacetonitrile aniline glycolonitrile formaldehydN-chlor°Carbonyl-N-phenyl-glycine nitrileN-chlor°Carbonyl-N-phenyl-glycine nitrile N-ethyl-N-phenylamine 2-anilinoacetamide N-nitroso-N-phenyl-glycine nitrileN-nitroso-N-phenyl-glycine nitrile 六氢-1,3,5-三苯基-1,3,5-三嗪置于sodium Hydrogensulfite体系中,化学反应生成 苯胺基乙腈
参考文献:Bucherer; Schwalbe,Chemische Berichte,1906,Vol. 39,P. 2801
标题:Bucherer; Schwalbe,Chemische Berichte,1906,Vol. 39,P. 2801
专利信息
专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:US-2010105111-A1
优先权日:2007-02-28
标 题 :Method for production of optically active amino acid
发明人:ASANO YASUHISA; TANAKA AKINORI; HASEMI RYUJI
权利人:MITSUBISHI GAS CHEMICAL CO
摘要:An optically active amino acid is useful as food or feed, agrochemicals, chemical products for industrial use, intermediates for synthesis of cosmetics or medicines and the like and is also important as optical resolving agents or chiral building blocks for use in organic synthesis. Thus, the object is to provide an industrially practical method for producing the optically active amino acid simply and at low cost. The method comprises the step of reacting an aminonitrile composed of a mixture of a D-aminonitrile and an L-aminonitrile with a biocatalyst which is one derived from a newly isolated microorganism belonging to the genus Rhodococcus and has an activity of converting the two aminonitriles into a D-amino acid amide and an L-amino acid amide respectively, a biocatalyst which has an activity of racemizing the D-amino acid amide and the L-amino acid amide to each other, and a biocatalyst which has an activity of converting one of the D-amino acid amide and the L-amino acid amide into the corresponding D- or L-amino acid.
专利号:WO-2023226263-A1
优先权日:2022-05-26
标题:Anilinoacetate and synthesis method therefor
发明人:TANG BO; ZHENG BOCHUAN; DING YONGLIANG; KANG XIAOLING; ZOU ZHIGANG; LIANG YONGJUN; GONG YIGUI
权利人:SHANGHAI DODGEN CHEMICAL TECH CO LTD
摘要:The present invention relates to the technical field of organic synthesis, in particular to an anilinoacetate and a synthesis method therefor. The synthesis method for an anilinoacetate comprises: S1, adding an anilinoacetate solution and anilinoacetonitrile to an alkali liquor, and subjecting same to an amidation reaction; S2, an alkaline hydrolysis reaction, involving: adding the alkaline liquor to the solution obtained after the amidation reaction, and subjecting same to the alkaline hydrolysis reaction to obtain an anilinoacetate. In the present invention, by adding the target product, namely an anilinoacetate solution, in the amidation reaction step, the reaction system is homogeneous, the miscibility and mass transfer efficiency of anilinoacetonitrile and an alkali liquor are improved, and the technical problems of poor contact and low reaction efficiency caused by the layering of the anilinoacetonitrile and the alkali liquor are avoided, such that the amidation reaction time is shortened, and the utilization rate and capacity of an apparatus are improved.
专利号:US-5686625-A
优先权日:1993-12-27
标题:Process for the preparation of N-substituted glycine acids or glycine esters and the use of the process for indigo synthesis
发明人:KOS CARLO
权利人:CHEMIE LINZ GMBH
摘要:PCT No. PCT/EP94/04259 Sec. 371 Date Jun. 5, 1996 Sec. 102(e) Date Jun. 5, 1996 PCT Filed Dec. 21, 1994 PCT Pub. No. WO95/18093 PCT Pub. Date Jul. 6, 1995Process for the preparation of an N-substituted glycine ester or an N-substituted glycine acid by reaction of a glyoxylic acid ester half-acetal (hemiacetal) or glyoxylic acid half-acetal (hemiacetal) with an amine and hydrogenation of the intermediate product formed by this reaction, and the use of the process in a process for the preparation of indoxyl and indigo derivatives by cyclization of an N-arylglycine ester, prepared by the above process, in a molten alkali metal carbonate or alkaline earth metal carbonate with or without addition of an alkali metal amide, and if appropriate oxidation of the indoxyl derivative formed by this reaction to give the corresponding indigo derivative.
专利号:US-2023303568-A1
优先权日:2022-03-25
标题 :Intermediate useful for the synthesis of tgf-beta inhibitors and a method of preparing tgf-beta inhibitors using the same
专利号:US-3190917-A
优先权日:1961-06-08
标 题 :Synthesis of alpha-amino acid amide hydrohalides
发明人:JOHNSON HERBERT E; CROSBY DONALD G
权利人:UNION CARBIDE CORP