CAS: 4152-90-3; (3-Chlorophenyl)Methanamine

上下游产品

1-(叠氮甲基)-3-氯苯 3-Chlorobenzylazide 126799-85-7
3-氯苄溴 1-Bromomethyl-3-Chlorobenzene 766-80-3
3-氯苯甲醇 M-Chlorobenzyl Alcohol 873-63-2
3-氯苯甲醛 3-Chlorobenzaldehyde 587-04-2
间氯氯苄 1-Chloro-3-Chloromethyl-Benzene 620-20-2
苄胺 Benzylamine 100-46-9
3-氯苯乙烯 3-Chlorostyrene 2039-85-2
3-氯苯腈 3-Chloro-Benzonitrile 766-84-7

3-氯苯乙烯置于葡萄糖,E. Coli Lz220,氨,氧气,氯化铵体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应 24.0H,以51%的收率获得产物3-氯苄胺
参考文献:通过九步人工酶级联反应和工程代谢途径从可再生原料生物生产苄胺
标题:通过九步人工酶级联反应和工程代谢途径从可再生原料生物生产苄胺
摘要:从可再生原料生产化学品一直是可持续化学工业的重要任务.尽管微生物发酵已被广泛用于生产许多生物化学物质,但获取非天然化学物质仍然非常困难.已开发出两种方法(生物转化和发酵)用于第一种生物衍生的苄胺的合成,苄胺是一种具有广泛应用的商品非天然胺.首先,通过生物催化逆合成分析设计了九步人工酶级联反应,并在重组大肠杆菌lz243中进行了工程改造.大肠杆菌细胞对l-苯丙氨酸(60 M M)的生物转化产生了苄胺(42 M M)的转化率达到70%.重要的是,将级联生物转化放大至100 Ml,并成功分离出苄胺,收率为57%.其次,通过将九步级联反应与细胞中增强的1-苯丙氨酸合成途径相结合,开发了一种从葡萄糖到苄胺的人工生物合成途径.发酵用大肠杆菌lz249得到苄胺4.3米米浓度葡萄糖.此外,还可以通过容易获得的苯乙烯一锅法合成几种有用的苄胺,这代表了通过正式的氧化裂解和还原胺化作用实现的新型烯烃转化.
DOI:10.1002/cssc.201800709

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-9018371-B2
优先权日:2007-03-07
标 题 :Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient
发明人：JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH
权利人:JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH; FM THERAPEUTICS CO LTD; US OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES THE OFFICE OF TECHNO
摘要:Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A 3 adenosine receptors and act as A 3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.

专利号:US-4734495-A
优先权日:1985-07-17
标 题 :Process and intermediates for beta-lactam antibiotics
发明人：EVANS DAVID A; SJOGREN ERIC B
权利人:HARVARD COLLEGE
摘要:1-Benzyl(or substituted benzyl)-3β-[4(S)-aryloxazolidin-2-one-3-yl]-4β-(2-arylvinyl)azetidin-2-ones are provided via cycloaddition of a 4(S)-aryloxazolidin-2-one-3-ylacetyl halide and an imine formed with a benzylamine and a 3-arylacrolein, e.g. cinnamaldehyde. The azetidinones are useful chiral intermediates in an asymmetric synthesis of 1-carba(1-dethia)-3-hydroxy-3-cephem-4-carboxylic acids and esters and to monocyclic β-lactam antibiotics.

专利号:US-4870169-A
优先权日:1985-07-17
标 题:Intermediates for beta-lactam antibiotics
发明人：EVANS DAVID A; SJOGREN ERIC B
权利人:HARVARD COLLEGE
摘要:1-Benzyl(or substituted benzyl)-3β-[4(S)-aryloxazolidin-2-one-3-yl]-4β-(2-arylvinyl)azetidin-2-ones are provided via cycloaddition of a 4(S)-aryloxazolidin-2-one-3-ylacetyl halide and an imine formed with a benzylamine and a 3-arylacrolein, e.g. cinnamaldehyde. The azetidinones are useful chiral intermediates in an asymmetric synthesis of 1-carba(1-dethia)-3-hydroxy-3-cephem-4-carboxylic acids and esters and to monocyclic β-lactam antibiotics.

专利号:CN-119140080-A
优先权日:2024-11-14
标题 :A titanium oxide film catalytic material for rapid and high-yield synthesis of imines, and preparation method and use thereof

专利号:US-2023104311-A1
优先权日:2020-02-17
标题:Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments
发明人：HERDEWIJN PIET; GROAZ ELISABETTA; QINGFENG LI
权利人:UNIV LEUVEN KATH
摘要:The present invention relates to the synthesis of 6-substituted 7-deazapurines and their corresponding nucleosides by coupling aryl or alkyl Grignard reagents with halogenated purine nucleosides in the presence of iron or an iron/copper mixture such as Fe(acac)3/CuI. The present invention also relates to pharmaceutical compositions comprising said compounds and the use of said pharmaceutical compositions to treat or prevent viral infections.