(Benzyloxy)Benzene置于chromium(Vi) Oxide,盐酸,溶剂黄146,Zinc(II) Chloride体系中,化学反应生成 4-甲氧基二苯甲酮 参考文献:Short; Stewart,Journal Of The Chemical Society,1929,P. 559 标题:Short; Stewart,Journal Of The Chemical Society,1929,P. 559
专利号:US-10865390-B2 优先权日:2018-02-12 标 题 :Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols 发明人:NI YE; ZHOU JIEYU; XU GUOCHAO; WANG YUE 权利人:UNIV JIANGNAN 摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.
专利号:US-10822593-B2 优先权日:2018-02-12 标 题:Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols 发明人:NI YE; ZHOU JIEYU; XU GUOCHAO; WANG YUE 权利人:UNIV JIANGNAN 摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.
专利号:US-11078465-B2 优先权日:2018-02-12 标题:Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols 发明人:NI YE; WANG YUE; DAI WEI; XU GUOCHAO; ZHOU JIEYU 权利人:UNIV JIANGNAN 摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.
专利号:WO-2018011378-A1 优先权日:2016-07-13 标 题 :Method for the synthesis of a polyolefin by means of romp in the presence of a ruthenium-based catalyst 发明人:PINAUD JULIEN; CHEMTOB ABRAHAM; HEROGUEZ VALÉRIE; PLACET EMELINE; SAUVANIER DAVID; LACROIX-DESMAZES PATRICK 权利人:CENTRE NATIONAL DE LA RECHERCHE SCIENT (CNRS); UNIV MONTPELLIER; UNIV BORDEAUX; BORDEAUX INP; UNIV HAUTE ALSACE; AXLR SATT DU LANGUEDOC ROUSSILLON; ENSCM 摘要:The present invention relates to a method for the synthesis of a polyolefin by means of a photoinitiated ROMP reaction involving a cyclic olefin in the presence of a ruthenium-based catalyst of formula (I), in which the catalyst is generated in situ under UV radiation from an inactive ruthenium complex of formula [RuCl 2 (L)] 2 and an imidazoli(ni)um salt of formula (III).
专利号:US-11192912-B1 优先权日:2020-10-15 标 题 :Synthesis of biaryl ketones and biaryl diketones via carbonylative Suzuki-Miyaura coupling reactions catalyzed by bridged bis(N-heterocyclic carbene)palladium(II) catalysts 发明人:EL ALI BASSAM; MANSOUR WASEEM; FETTOUHI MOHAMMED 权利人:UNIV KING FAHD PET & MINERALS; SAUDI ARABIAN OIL CO 摘要:This disclosure relates to bridged bis(N-heterocyclic carbene)palladium(II) complexes, methods of preparing the complexes, and methods of using the complexes in Suzuki-Miyaura coupling reactions.
专利号:US-4500707-A 优先权日:1980-02-29 标题:Nucleosides useful in the preparation of polynucleotides 发明人:CARUTHERS MARVIN H; MATTEUCCI MARK D 权利人:UNIVERSITY PATENTS INC 摘要:New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic acids (DNA).