CAS: 623-50-7; Ethyl 2-Hydroxyacetate

相似化合物

50595-15-8 3938-96-3 30379-58-9

上下游产品

CAS号105-36-2 溴乙酸乙酯 | CAS号79-14-1 羟基乙酸 | CAS号64-17-5 乙醇 | CAS号623-73-4 重氮乙酸乙酯 | CAS号107-43-7 甜菜碱 | CAS号50-00-0 甲醛 | CAS号105-39-5 氯乙酸乙酯 | CAS号95-92-1 草酸二乙酯 | CAS号502-97-6 乙交酯 | CAS号105544-30-7 2-(5-溴-3-硝基-2-吡... | CAS号112333-59-2 ethyl 2-(cyanom... | CAS号4856-97-7 2-羟甲基苯并咪唑 | CAS号32122-09-1 苄氧基乙酸乙酯 | CAS号5372-40-7 (3-(4-氯苯基)-1,2,... | CAS号3530-14-1 2-羟基乙酰肼 | CAS号371945-06-1 3-氨基呋喃并[2,3-b]吡... | CAS号15224-07-4 ETHYL PROPIONYL... | CAS号91497-39-1 (苯基乙酰氧基) 乙酸乙酯 | CAS号924-44-7 乙醛酸乙酯

草酸二乙酯置于乙醇,C42H44Cln4P2Ru(1+)*cl(1-),Potassium Tert-Butylate体系中,化学反应 5.0H,以94%的收率获得产物乙醇酸乙酯
参考文献:钌催化的腈,芳烃,烯烃,炔烃和酯的转移加氢
标题:钌催化的腈,芳烃,烯烃,炔烃和酯的转移加氢
摘要:本文报道了吡唑-膦配体支持的新型钌(II)配合物的制备及其在转移各种底物的氢化反应中的应用.发现这些ru络合物是用于还原腈和烯烃的有效催化剂.杂环化合物以非常好至中等的产率进行转移氢化,提供了所有碳环不寻常氢化的实例.具有大取代基的内部炔烃具有选择性的还原成具有异常e-选择性的烯烃的能力.如果使用乙醇作作为反应溶剂,则具有强吸电子基团的酯可以还原为相应的醇.在动力学研究和标记实验的基础上,提出了氢化和烯烃异构化的可能机理.
DOI:10.1002/cctc.201801039

专利信息

专利号:US-5827794-A
优先权日:1994-02-22
标 题 :Supported highly-polar liquid phase chiral sulfonated binap catalyst for asymmetric synthesis of optically active compounds
发明人：DAVIS MARK E; WAN KAM TO
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention relates to water soluble chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl and its use as organometallic catalysts for asymmetric synthesis of optically active compounds. Asymmetric reactions of the present invention include those reactions in which organometallic catalysts are commonly used. Such reactions include, but are not limited to, reduction and isomerization reactions on unsaturated substrates and carbon--carbon bond forming reactions. Examples of such reactions include, but are not limited to, hydrogenation, hydroboration, hydrosilylation, hydride reduction, hydroformylation, alkylation, allylic alkylation, arylation, alkenylation, epoxidation, hydrocyanation, disilylation, cyclization and isomerization reactions. n The catalysts of the present invention provide the advantage of functioning in the presence of water without loss in enantioselectivity relative to the nonsulfonated BINAP catalyst in an organic solvent. As a result, the catalysts of the present invention may be employed in water, water miscible solvents, in aqueous--organic two phase solvent systems and in supported aqueous phase catalysts in organic solvents without loss in enantioselectivity. Further, the catalysts of the present invention may also be effectively employed in highly polar solvents such as primary alcohols and ethylene glycol. n The present invention also relates to a method for conducting asymmetric reactions on prochiral unsaturated bonds contained within a compound using the water soluble chiral sulfonated 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl organometallic catalysts of the present invention.

专利号:EP-0790982-B1
优先权日:1994-06-17
标 题 :Methods of synthesis of peptidyl argininals
发明人：WEBB THOMAS R; REINER JOHN E; TAMURA SUSAN Y; RIPKA WILLIAM C; DAGNINO RAYMOND JR; NUTT RUTH F
权利人:CORVAS INT INC
摘要:This invention provides solution-phase and solid-phase methods for the synthesis of peptidyl argininals and to novel reagents useful therein, which have formula (I), wherein R1 is selected from the group consisting of hydrogen, benzyloxycarbonyl, isonicotinyloxycarbonyl, 2-chlorobenzyloxycarbonyl, 4-methoxybenzyloxycarbonyl, t-butoxycarbonyl, t-amyloxycarbonyl, isobornyloxycarbonyl, adamantyloxycarbonyl, 2-(4-biphenyl)-2-propyloxycarbonyl, 9-fluorenylmethoxycarbonyl and methylsulfonylethoxycarbonyl; R2 is selected from the group consisting of alkyl of 1 to about 12 carbon atoms and aralkyl of about 7 to about 15 carbon atoms, either of which is optionally substituted with hydroxy or -CO-Y, wherein Y is hydroxy, alkoxy of 1 to about 12 carbon atoms, aralkoxy of about 7 to about 15 carbon atoms, O-polymeric support or NH-polymeric support; R3 is selected from the group consisting of hydrogen, Fmoc, nitro, benzyloxycarbonyl, t-butoxycarbonyl and adamantyloxycarbonyl; and R4 is selected from the group consisting of hydrogen, alkyl of 1 to about 12 carbon atoms, aryl of about 6 to about 14 carbon atoms and aralkyl of about 7 to about 15 carbon atoms; and salts thereof.

专利号:US-4704450-A
优先权日:1983-02-21
标 题 :Synthesis of hpGRF(Somatocrinin) in liquid phase and intermediate peptides
发明人：DIAZ JOSEPH; DEMARNE HENRI; RONCUCCI ROMEO; SCHMELCK PAUL-HENRY
权利人:SANOFI SA
摘要:The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising: coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group; selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.

专利号:US-4581168-A
优先权日:1983-02-21
标题:Synthesis of hpGRF (Somatocrinin) in liquid phase and intermediate peptides
发明人：DIAZ JOSEPH; DEMARNE HENRI; RONCUCCI ROMEO; SCHMELCK PAUL-HENRY
权利人:SANOFI SA
摘要:The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising:--coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group;--selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and--eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.

专利号:US-3968112-A
优先权日:1974-08-02
标 题:Synthesis of penniclavine and elymoclavine
发明人：KORNFELD EDMUND C; BACH NICHOLAS J
权利人:LILLY CO ELI
摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.

专利号:US-5731413-A
优先权日:1994-06-17
标 题:Method of synthesis of peptidyl aldehydes
发明人：WEBB THOMAS ROY; REINER JOHN EUGENE; TAMURA SUSAN YOSHIKO; RIPKA WILLIAM CHARLES; DAGNINO JR RAYMOND; NUTT RUTH FOELSCHE
权利人:CORVAS INT INC
摘要:This invention provides solution-phase and solid-phase methods for the synthesis of peptidyl argininals and to novel! reagents useful therein.