CAS: 925-90-6; Ethylmagnesium Bromide

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CAS号74-96-4 溴乙烷 | CAS号7439-95-4 镁标准溶液 | CAS号75-03-6 碘乙烷 | CAS号993-84-0 diethyl-hydrido... | CAS号110-05-4 二叔丁基过氧化物 | CAS号86901-19-1 MAGNESIUMANTHRA... | CAS号60-29-7 乙醚 | CAS号41141-89-3 bromo-triethyl-... | CAS号1060811-36-0 1-(6-bromopyrid... | CAS号1565-75-9 2-苯基-2-丁醇 | CAS号10192-93-5 3,4-二甲基-3,4-二苯基己烷 | CAS号111708-22-6 trimethyl(3-tri... | CAS号10605-66-0 4-甲基-2-丙炔-1,4-二醇 | CAS号10500-11-5 乙酸1-戊烯-3-基酯 | CAS号107-26-6 ethylmercury bromide | CAS号1006037-03-1 4-(1-氨基环丙基)苯甲酸甲酯 | CAS号109000-86-4 9-ethyl-10-meth... | CAS号1060806-97-4 1-(6-methoxypyr...

溴乙烷置于magnesium体系中,用 乙醚 作为反应溶剂,化学反应生成 乙基溴化镁
参考文献:4-Alkyl-3-Azidomethyl-2-Ethoxy-2,5-Dihydro-5H-1,2-Oxaphosphole 2-Oxides: Synthesis And 1,3-Cycloaddition
标题:4-Alkyl-3-Azidomethyl-2-Ethoxy-2,5-Dihydro-5H-1,2-Oxaphosphole 2-Oxides: Synthesis And 1,3-Cycloaddition
摘要:从磷酸化的丙二烯开始,开发了一种具有 1,2-氧杂磷烯碳骨架的新型有机叠氮化物的三步合成.该系列得到的4-烷基-3-叠氮基甲基-2-乙氧基-2,5-二氢-5-ħ-1,2-Oxaphosphole 2氧化物中使用了1,3-环加成与烷基2-[1-(Propyn-2-yl)-1 H-Indol-3-Yl]-2-Oxoacetates 用于合成偶联物,这是潜在的活性细胞抑制剂.
DOI:10.1055/s-0040-1720922

专利信息

专利号:US-5849936-A
优先权日:1995-03-15
标题:Method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins
发明人：HOYE THOMAS R; TAN LUSHI
权利人:UNIVERISTY OF MINNESOTA
摘要:A method for the synthesis of bis-tetrahydrofranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:US-5442065-A
优先权日:1993-09-09
标 题:Synthesis of tetrahydroquinoline enediyne core analogs of dynemicin
发明人：MAGNUS PHILIP D; ILIADIS THEODORE; EISENBEIS SHANE A; FAIRHURST ROBIN A
权利人:UNIV TEXAS
摘要:A process is described for the preparation of the core azobicyclo[7.3.1]tridecaenediyne moiety of the antitumor antibiotic dynemicin. The synthesis allows efficient production of the enediyne as a stable, compound in good yield from the adamantyl N-protected azabicyclo[7.3.1]tridecadiyne. The adamantyl protecting group is employed in the starting material, N-adamantyl dihydroquinoline or N-adamantyl 6-methoxy quinoline. Also disclosed are process for the synthesis of 3-hydroxy-6-methoxyquinoline and several N-substituted derivatives of azobicyclo[7.3.1]tridecaenediyne. Solid tumor and leukemia assays were performed on the analogs of dynemicin. The results suggest a method that these compounds will useful in treating certain types of leukemias and solid tumors. The disclosed synthesis provides a route to new dynemicin intermediates and analogs which will allow development of second and third generation dynemicins.

专利号:US-4311645-A
优先权日:1980-03-24
标 题 :Synthesis of SRS-active compounds
发明人：ROSENBERGER MICHAEL
权利人:HOFFMANN LA ROCHE
摘要:A chemical synthesis of an SRS-A active compound from the reaction product of 1-halo-2-octyne and the ether of 2-penten-4-yn-1-ol including intermediates in the synthesis, some of which being antagonists of SRS-A useful for treating allergic reactions.

专利号:US-4384998-A
优先权日:1981-03-30
标题:Synthesis of thienamycin from D-glucose
发明人：DURETTE PHILIPPE L
权利人:MERCK & CO INC
摘要:Disclosed is a chiral, total synthesis of thienamycin from D-glucose which proceeds via intermediates I, II and III to known aldehyde IV which is known to be useful in the total synthesis of thienamycin (V): ##STR1## wherein: R is lower alkyl having 1-6 carbon atoms or bi-valent alkyl having 2-6 carbon atoms which joins the two sulfur atoms; R 1 is lower alkyl or aralkyl, such as benzyl and the like; and R 2 is hydrogen or a removable protecting group, such as triorganosilyl wherein the organo groups are independently selected from lower alkyl, phenyl and phenylloweralkyl.

专利号:US-4448976-A
优先权日:1981-03-30
标题 :Chiral synthesis of thienamycin from D-gluocose
发明人：DURETTE PHILIPPE L
权利人:MERCK & CO INC
摘要:Disclosed is a chiral, total synthesis of thienamycin from D-glucose which proceeds via intermediates I, II and III to known aldehyde IV which is known to be useful in the total synthesis of thienamycin (V): ##STR1## wherein: R is lower alkyl having 1-6 carbon atoms or bi-valent alkyl having 2-6 carbon atoms which joins the two sulfur atoms; R 1 is lower alkyl or aralkyl, such as benzyl and the like; and R 2 is hydrogen or a removable protecting group, such as triorganosilyl wherein the organo groups are independently selected from lower alkyl, phenyl and phenylloweralkyl.