CAS: 100564-78-1; (S)-2-((Tert-Butoxycarbonyl)Amino)-4-Phenylbutanoic Acid

相似化合物

82732-07-8 1012-05-1 127862-89-9

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号75553-23-0 5-phenylpent-2-... | CAS号91-00-9 二苯甲胺 | CAS号82795-51-5 D-苯基丁氨酸 | CAS号29678-81-7 (R)-2-羟基-4-苯丁酸

Boc-L-丝氨酸甲酯置于sodium Tetrahydroborate,Disodium Hydrogenphosphate,重铬酸吡啶,正丁基锂,Sodium Amalgam,4-甲基苯磺酸吡啶,间氯过氧苯甲酸体系中,用 吡啶,甲醇,乙醇,二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 65.0H,反应生成Boc-L-高苯丙氨酸
参考文献:从l-丝氨酸合成l和d构型的光学纯非蛋白质α-氨基酸的新方法
标题:从l-丝氨酸合成l和d构型的光学纯非蛋白质α-氨基酸的新方法
摘要:描述了由l-丝氨酸有效合成(2R)-2-Boc-氨基-3-苯基磺酰基-1-丙醇3及其对映异构体9.通过制备n-Boc-L-和d-高苯丙氨酸,-正缬氨酸和-,可以举例说明这些化合物在合成l和d构型的光学纯非蛋白质α-氨基酸的新颖通用方法中的潜力.正亮氨酸.
Doi:10.1016/s0040-4039(00)96866-7

专利信息

专利号:US-10975096-B2
优先权日:2014-06-20
标题 :Synthesis of polycyclic-carbamoylpyridone compounds
发明人：CHIU ANNA; ENQUIST JR JOHN; GRIGGS NOLAN; HALE CHRISTOPHER; IKEMOTO NORIHIRO; KEATON KATIE ANN; KRAFT MATT; LAZERWITH SCOTT E; LEEMAN MICHEL; PENG ZHIHUI; SCHRIER KATE; TRINIDAD JONATHAN; VAN HERPT JOCHEM; WALTMAN ANDREW W
权利人:GILEAD SCIENCES INC
摘要:Methods of making compounds of Formula I are disclosed:

专利号:US-9822145-B2
优先权日:2014-10-27
标题:Methods of making carfilzomib and intermediates thereof
发明人：KOVI RAVISHANKER; KANNAPAN JAYARAMAN; RAMU VASANTHAKUMAR G; PRASAD ALAPARTHI LAKSHMI; CHOWDARY TALLURI BHUSHAIAH; KULKARNI GAURAV; AHMED SAIYED AKEEL AHMED SHAKEEL; BOBBILI VEERABHADRA RAO; DUSANAPUDI N V RAGHAVALU; MANTRI ANAND V
权利人:APICORE US LLC
摘要:Racemization-free methods are disclosed for the synthesis of carfilzomib. Novel intermediates and methods of making carfilzomib employing fragment condensation using the novel intermediates are disclosed. Amorphous carfilzomib and methods of making same are disclosed.

专利号:EP-3041856-A1
优先权日:2013-09-06
标题 :Synthesis of peptide epoxy ketones

专利号:ES-2821143-T3
优先权日:2014-06-20
标题:Synthesis of polycyclic carbomoylpyridone compounds

专利号:CN-105518019-A
优先权日:2013-09-06
标 题 :Synthesis of Peptide Epoxy Ketones

专利号:US-2016215016-A1
优先权日:2013-09-06
标 题 :Synthesis of peptide epoxy ketones
发明人：HÖFERL-PRANTZ KATHRIN; WILHELM THORSTEN
权利人:SANDOZ AG
摘要:It is provided an improved process for preparing peptide epoxy ketones, including novel compounds that can be used as intermediates in the process for preparing Carfilzomib and other peptide epoxy ketones.