CAS: 108963-96-8; 1-(Tert-Butyl) 2-Methyl (S)-5-Oxopyrrolidine-1,2-Dicarboxylate

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128811-48-3 4931-66-2 190783-99-4

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号4931-66-2 L-焦谷氨酸甲酯 | CAS号67-56-1 甲醇 | CAS号98-79-3 L-焦谷氨酸 | CAS号59936-29-7 (S)-1-叔-丁基-2-甲基... | CAS号34619-03-9 碳酸二叔丁酯 | CAS号53100-44-0 N-叔丁氧羰基-L-焦谷氨酸 | CAS号74-88-4 碘甲烷 | CAS号88668-76-2 L-Norvaline, 5-... | CAS号188200-05-7 (S)-1-叔丁基 2-甲基 ... | CAS号334769-80-1 (2S,5S)-N-B°C-5... | CAS号364750-80-1 (2S,4R)-1-(叔丁氧羰... | CAS号59936-29-7 (S)-1-叔-丁基-2-甲基... | CAS号4931-66-2 L-焦谷氨酸甲酯 | CAS号196394-49-7 Methyl (2S,4R)-... | CAS号196394-48-6 (2S,4S)-1-(叔丁氧羰... | CAS号158392-74-6 甲基 (2S)-1-(叔-丁氧... | CAS号163513-98-2 (1R,4S)-7-叔丁氧羰基... | CAS号83548-46-3 N-B°C-L-脯氨酸-4-烯甲基酯 | CAS号147-85-3 脯氨酸

L-焦谷氨酸置于4-二甲氨基吡啶,氯化亚砜,三乙胺体系中,用 二氯甲烷 用作溶剂,化学反应 62.0H,反应生成Boc-L-焦谷氨酸甲酯
参考文献:分子内烷基化方法合成双环和三环手性胍盐
标题:分子内烷基化方法合成双环和三环手性胍盐
摘要:描述了导致三种新型手性胍支架的合成研究.感兴趣的结构包括在胍核心周围具有各种取代模式的双环胍衍生物,以及高度刚性的三环支架.通过应用汞 (II) 促进的 N-Boc 取代硫脲的鸟苷酸化和 Ishikawa 的脱硫环化来获得具有挑战性的目标.除了我们的合成逻辑之外,还介绍了三环胍盐的可扩展合成.
Doi:10.1002/ejoc.201601154

专利信息

专利号:US-2023271921-A1
优先权日:2020-06-10
标题:Synthesis of (2s,5r)-5-(2-chlorophenyl)-1-(2'-methoxy-[1,1'-biphenyl]-4- carbonyl)pyrrolidine-2-carboxylic acid
发明人：DUTHEUIL GUILLAUME
权利人:EPICS THERAPEUTICS
摘要:A process of manufacturing of (2S,5R)-5-(2-chlorophenyl)-1-(2′-methoxy-[1,1′-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid (1), including the preparation of (2S,5R)-methyl 5-(2-chlorophenyl)pyrrolidine-2-carboxylate hydrochloride (6·HCl) as an intermediate of synthesis:Also, the sodium salt of the (2S,5R)-5-(2-chlorophenyl)-1-(2′-methoxy-[1,1′-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid (1), and its use in a pharmaceutical composition including sodium the (2S,5R)-5-(2-chlorophenyl)-1-(2′-methoxy-[1,1′-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylate and a method for treating and/or preventing inflammation in a patient.

专利号:US-2008058528-A1
优先权日:2006-07-20
标题 :Synthesis of (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile

专利号:WO-2021250174-A1
优先权日:2020-06-10
标 题 :Synthesis of (2s,5r)-5-(2-chlorophenyl)-1-(2'-methoxy-[1,1'-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid

专利号:EP-2057145-B1
优先权日:2006-07-20
标 题:Synthesis of (2s,5r)-5-ethynyl-1-{n-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile

专利号:US-2016152600-A1
优先权日:2006-07-20
标题 :Synthesis of (2s,5r)-5-ethynyl-1-pyrrolidine-2-carbonitrile

专利号:CN-115768747-A
优先权日:2020-06-10
标题:Synthesis of (2S,5R)-5-(2-chlorophenyl)-1-(2′-methoxy-[1,1′-biphenyl]-4-carbonyl)pyrrolidine-2-carboxylic acid