CAS: 122-59-8; 2-Phenoxyacetic Acid

相似化合物

122-99-6 2065-23-8 2555-49-9

上下游产品

CAS号2555-49-9 苯氧乙酸乙酯 | CAS号93-76-5 2,4,5-涕 | CAS号79-11-8 氯乙酸 | CAS号108-95-2 苯酚 | CAS号122-88-3 4-氯苯氧乙酸 | CAS号1746-13-0 烯丙基苯基醚 | CAS号94-75-7 2,4-二氯苯氧乙酸 | CAS号105-39-5 氯乙酸乙酯 | CAS号87-08-1 青霉素V | CAS号621-88-5 苯氧乙酰胺 | CAS号110522-74-2 2'-脱氧-N6-苯氧基乙酰基腺苷 | CAS号4664-55-5 苯氧乙酰肼 | CAS号3598-14-9 苯氧基乙腈 | CAS号38678-58-9 2,5-二氧代吡咯烷-1-基 ... | CAS号40515-89-7 苯氧基乙苯 | CAS号14231-49-3 (2S)-2-[(2-phen... | CAS号4461-15-8 2,4-二氢-4-氨基-5-(... | CAS号94-75-7 2,4-二氯苯氧乙酸 | CAS号18861-22-8 Acetamide,N-[(4... | CAS号18861-18-2 N-(4-chlorophen...

苯氧乙酸烯丙酯置于carreira's Cobalt Catalyst,1,1,3,3-四甲基二硅氧烷,Tetrabutylammonium Tetrafluoroborate体系中,用 甲醇 用作溶剂,以89%的收率获得苯氧乙酸
参考文献:烯烃通过 Co(Ii/iii/iv) 循环的电催化氧化加氢官能化反应
标题:烯烃通过 Co(Ii/iii/iv) 循环的电催化氧化加氢官能化反应
摘要:在这里,我们公开了一种用于烯烃官能化的通用 Co(Ii/iii/iv) 电催化平台.在电力驱动下,证明了一组通过氢原子转移的氧化氢官能化反应,不需要化学计量的化学氧化剂.反应范围包括加氢烷氧基化,加氢酰氧基化,加氢芳基化,半频哪醇重排和去烯丙基化.机理研究和立体化学证据支持涉及电化学生成的有机钴 (Iv) 中间体的 Ecec 过程.这项工作通过超越 Co(I/ii/iii) 的常见氧化态,展示了 Vb 12系统中电催化中反应性空间扩展的示例.
Doi:10.1021/acscatal.1C05557

专利信息

专利号:WO-9002605-A1
优先权日:1988-09-02
标题:An apparatus and a method for the synthesis of peptides
发明人：MELDAL MORTEN; HOLM ARNE; BUCHARDT OLE
权利人:MELDAL MORTEN; HOLM ARNE; BUCHARDT OLE
摘要:An apparatus for use in chemical synthesis, especially peptide synthesis, comprises a synthesis chamber unit having a multiplicity of synthesis chambers, each of which has a liquid inlet and a liquid outlet, means for introducing liquid into the individual synthesis chambers and means for simultaneous removal of liquid via the liquid outlets of the synthesis chambers by regulation of the fluid pressure difference between the liquid inlets and the liquid outlets. A method for peptide synthesis using such an apparatus comprises the provision in each of the synthesis chambers of a solid-phase support material having a first, at least N-protected amino acid coupled thereto, after which a liquid deprotection reagent is introduced into the synthesis chambers. Following deprotection, the deprotection reagent is removed, after which a second, at least N-protected amino acid is introduced into each synthesis chamber in order to couple the first and second amino acids. Third, fourth, etc. amino acids may be coupled analogously. Complete removal of the deprotection reagent from the synthesis chambers and the support material can be ensured by incorporating a stable, intensely coloured dye, e.g., azorubin, in the deprotection reagent. The apparatus and the method make possible the parallel synthesis of a large number of peptides, e.g. peptides having overlapping amino acid sequences and constituting part of a longer peptide chain. The apparatus can be adapted to manual, semi-automatic or fully automatic performance of the various steps in the synthesis procedure.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:US-6515039-B1
优先权日:1998-08-28
标 题:Method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material
发明人：ULBRICHT MATHIAS; VOLKMER-ENGERT RUDOLF; GERMEROTH LOTHAR; WENSCHUH HOLGER
权利人:POLY AN GMBH
摘要:The invention relates to a method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material. According to the method, a continuous polymeric solid phase supporting material is prepared, the material comprising a matrix of a supporting polymeric material and graft copolymer chains covalently bound to the supporting matrix, the graft copolymer chains having reactive groups being able to react with organic compounds, thereby forming spatially defined reaction sites. The method then comprises the sequential spotting of synthesis building blocks or reagents at the various reaction sites on the continuous solid phase supporting material to yield a substrate library of compounds bound to the solid phase supporting material, whereby each reaction site on the continuous solid phase supporting material determines the composition of the synthesized compound, which is bound directly on the supporting matrix via the reactive groups of the graft polymer chain.

专利号:US-8293930-B1
优先权日:2004-06-25
标题 :One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
发明人：NAIDU RAGINA
权利人:NAIDU RAGINA; CHATHAM BIOTEC LTD
摘要:A process is provided for the semi-synthesis of taxane intermediates useful in the preparation of paclitaxel and docetaxel, in particular, the semi-synthesis of protected taxane intermediate in a one pot reaction of protecting the C-7 and C-10 positions and attaching a side chain at the C-13 position and subsequently deprotecting the group to form paclitaxel or docetaxel, and taxane intermediates.

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.