CAS: 143612-79-7; 3-(4-Chlorobutyl)-1H-Indole-5-Carbonitrile

相似化合物

143612-85-5 173150-58-8 847179-81-1

上下游产品

3-(4-chlorobutanoyl)-1H-indole-5-carbonitrile 1H-indole-5-carbonitrile 6-chlorohexanal 6-chloro-1-hexanol 3-[4-(4-p-methoxyphenylpiperazino)butyl]-5-cyanoindole

6-氯-1-己醇置于2,2,6,6-四甲基哌啶氧化物,磷酸,硫酸,碳酸氢钠,Potassium Bromide体系中,用 二氯甲烷,N,N-二甲基乙酰胺,水,甲苯 用作溶剂,化学反应 4.0H,反应生成3-(4-氯代丁基)-5-氰基吲哚
参考文献:合成 3-(4-氯丁基)-1H-Indole-5-Carbonitrile 的替代方法:一种抗抑郁药物盐酸维拉佐酮的关键中间体
标题:合成 3-(4-氯丁基)-1H-Indole-5-Carbonitrile 的替代方法:一种抗抑郁药物盐酸维拉佐酮的关键中间体
摘要:摘要 描述了一种合成 3-(4-氯丁基)-1H-吲哚-5-腈 (2) 的替代且高效的伸缩方法,该方法是合成盐酸维拉佐酮 (1) 的关键中间体.图形概要
Doi:10.1080/00397911.2014.944268

专利信息

专利号:US-2014275542-A1
优先权日:2013-03-15
标 题 :Synthesis of a serotonin reuptake inhibitor
发明人：TADDEI MAURIZIO; GIANNOTTI LUCA; ATTOLINO EMANUELE; ALLEGRINI PIETRO
权利人:DIPHARMA FRANCIS SRL
摘要:Process for the preparation of a piperazinyl derivative, and its intermediates, which has known activity as a serotonin reuptake inhibitor and is used in therapy for treating serious symptoms of depression in adults.

专利号:US-5977112-A
优先权日:1995-04-20
标 题:Process of making substituted benzofurans
发明人：BATHE ANDREAS; HELFERT BERND; BOTTCHER HENNING; SCHUSTER KURT
权利人:MERCK PATENT GMBH
摘要:Benzofurans of the formula I ##STR1## and their salts in which R 1 , R 2 and X have the meanings indicated in claim 1, are suitable as intermediates in the synthesis of medicaments and show effects on the central nervous system.

专利号:US-6531503-B1
优先权日:1999-07-10
标 题 :Benzofurane derivatives
发明人：BATHE ANDREAS; HELFERT BERND; BOETTCHER HENNING
权利人:MERCK PATENT GMBH
摘要:Benzofurane derivatives of formula (I), wherein R and R' have the meanings given in claim no. (1), and salts thereof are suitable for use as intermediate products in the synthesis of medicaments.

专利号:EP-2778165-A1
优先权日:2013-03-15
标 题 :Synthesis of a serotonin reuptake inhibitor

专利号:CN-103880729-A
优先权日:2014-03-27
标 题 :A new process for the synthesis of vilazodone intermediate 5-cyano-3(4-chlorobutyl)-indole

专利号:RU-2194048-C2
优先权日:1997-07-18
标 题 :Derivatives of piperazine, method of their synthesis and pharmaceutical composition