CAS: 151103-09-2; 3-(Cyclopropylmethoxy)-4-(Difluoromethoxy)Benzaldehyde

相似化合物

162401-62-9 162401-78-7 162401-69-6

上下游产品

3-环丙基甲氧基-4-羟基苯甲醛 3-(Cyclopropylmethoxy)-4-Hydroxybenzaldehyde 25934-52-5
4-二氟甲氧基-3-甲氧基苯甲醛 4-(Difluoromethoxy)-3-Methoxybenzaldehyde 162401-70-9
4-二氟甲氧基-3-羟基苯甲醛 4-Difluoromethoxy-3-Hydroxybenzaldehyde 151103-08-1
香草醛 Vanillin 121-33-5

3-羟基-4-苄氧基苯甲醛置于palladium 10% On Activated Carbon,氢气,Caesium Carbonate,Sodium Hydroxide体系中,用 乙酸乙酯,N,N-二甲基甲酰胺 用作溶剂,化学反应 5.0H,反应生成4-(二氟甲氧基)-3-(环丙基甲氧基)苯甲醛
参考文献:3-环丙甲氧基-4-烷氧基苯甲酰胺类磷酸二酯 酶4抑制剂
标题:3-环丙甲氧基-4-烷氧基苯甲酰胺类磷酸二酯 酶4抑制剂
摘要:本发明公开了新型3‑环丙甲氧基‑4‑烷氧基苯甲酰胺类磷酸二酯酶4抑制剂,所述的抑制剂是通式为式i或者式ⅱ所代表的化合物,其前药,或其可药用盐,或其溶剂化物:;其中r1是独立的甲基(Me‑)或者二氟甲基(Cf2H‑);R2是独立的h,Me或者et;R3是独立的h,Meo或者cl;Cnh2N+2为烷基,N>=2;为取代苯环或者吡啶环;X为c或者n;Y为c或者n.本发明的优点在于:其具有很高的体外酶抑制活性,能选择性作用于pde4上,且具有非常好的抗炎效果以及抗抑郁效果.

专利信息

专利号:US-9233925-B2
优先权日:2012-03-07
标 题:Process for preparation of roflumilast
发明人：CHEN YI-JING; PIKUL STANISLAW; KUO SHEN-CHUN; CHU GUO-DONG
权利人:SCINOPHARM CHANGSHU PHARMACEUTICALS LTD
摘要:The present invention provides novel processes for the preparation of N-substituted benzamides having the formula VIc: n nIn some embodiments, the invention provides a process for preparation of roflumilast and other pharmaceutically active species. Novel compounds, including intermediates for the synthesis of roflumilast, are also provided.

专利号:US-9321726-B2
优先权日:2012-10-17
标题:Process for preparing roflumilast
发明人：SALAET FERRE JOSEP; MARQUILLAS OLONDRIZ FRANCISCO
权利人:INTERQUIM SA
摘要:The invention relates to a process for the preparation of Roflumilast by reaction of an activated form of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid with an activating agent selected from (a) carbonyldiimidazole (CDI), (b) 1,1′-carbonyl-di-(1,2,4-triazol) (CDT), (c) 1,1′-carbonyl-bis-(2-methylimidazol), (d), 1′-carbonyl-dipyperidin, (e) N,N′-dicyclohexylcarbodiimide (DCC), (f) N,N′-diisopropylcarbodiimide (DIC), (g) 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and a combination of one of the previous (a)-(g) with (h) N-hydroxysuccinimide or (i) N-hydroxyphthalimide, and the subsequent reaction with 3,5-dichloropyridine-4-amine in the presence of an inorganic base. The invention also relates to the synthesis intermediates.

专利号:CN-116803986-A
优先权日:2023-06-27
标 题:A kind of synthesis method of roxadustat intermediate

专利号:CN-119371301-A
优先权日:2023-07-27
标题:Roflumilast middle Synthesis process of intermediate