CAS: 40137-22-2; 3-(Methylamino)Propane-1,2-Diol

相似化合物

167700-44-9 148983-25-9 137618-48-5

上下游产品

CAS号96-24-2 3-氯-1,2-丙二醇 | CAS号74-89-5 氨基甲烷 | CAS号60278-98-0 3-(N-苄基-N-甲基)-1... | CAS号556-52-5 缩水甘油 | CAS号160173-41-1 N-(2,3-dihydrox...

3-(N-苄基-N-甲基)-1,2-丙二醇置于palladium On Activated Charcoal 氢气体系中,用 甲醇 作为反应溶剂,化学反应 18.0H,反应生成 3-甲胺基-1,2-丙二醇
参考文献:酪氨酸激酶抑制剂.13.被设计为表皮生长因子受体的酪氨酸激酶活性抑制剂的可溶性7-取代的4-取代(4-((3-溴苯基)氨基)吡啶并[4,3-D]嘧啶)的构效关系.
标题:酪氨酸激酶抑制剂.13.被设计为表皮生长因子受体的酪氨酸激酶活性抑制剂的可溶性7-取代的4-取代(4-((3-溴苯基)氨基)吡啶并[4,3-D]嘧啶)的构效关系.
摘要:4-(苯基氨基)喹唑啉的一般类别是有效的(某些成员的ic50值<< 1 Nm),并且是通过在表皮生长因子受体(egfr)上的竞争性结合而选择性抑制表皮生长因子受体(egfr)酪氨酸激酶活性的抑制剂.酶,但许多早期类似物的水溶性差(<< 1 Mm).通过将类似的7-氟衍生物与在2-Buoh或1-Proh水溶液中的合适的胺亲核试剂.评价所有化合物抑制egf刺激的全长egfr酶的酪氨酸磷酸化作用的能力.还评估了选定的类似物在培养的a431人表皮样癌细胞中对egf受体自身磷酸化的抑制作用,以及对小鼠中a431肿瘤异种移植物的抑制作用.带有多种多元醇,阳离子和阴离子可溶取代基的类似物保留了活性,但就增加的水溶性(> 40 Mm)和保留总体抑制活性(针对分离的酶的ic50为0.5-10 Nm)而言最有效.在a431细胞中抑制egfr自磷酸化的8-40 Nm是弱碱性胺衍生物.这些结果与这些化合物与egf
DOI:10.1021/jm970366V

专利信息

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-5188769-A
优先权日:1992-03-26
标 题:Process for reducing the levels of fatty acid contaminants in polyhydroxy fatty acid amide surfactants
发明人：CONNOR DANIEL S; SCHEIBEL JEFFREY J; MURCH BRUCE P; MAO MARK H; GOSSELINK EUGENE P; SEVERSON JR ROLAND G
权利人:PROCTER & GAMBLE
摘要:The synthesis of polyhydroxy fatty acid amide surfactants exemplified by the compound C11H23C(O)N(CH3)CH2[CHOH]4CH2OH by reacting a fatty acid ester with an N-alkyl sugar amine can result in contamination of the product surfactant by residual sources of fatty acids. These residual fatty acids may be unacceptable in high sudsing detergent compositions, such as dishwashing liquids, especially with Ca or Mg cations. The process of this invention reacts such contaminants with alkyl amines or, especially, ethanolamine, to convert them into fatty alkyl- or alkanolamides, which are quite acceptable in fully-formulated detergent compositions for home or industrial use.

专利号:US-3795682-A
优先权日:1970-07-27
标题 :Synthesis of cyclic ketals
发明人：DELAVARENNE S
权利人:UNION CARBIDE CORP
摘要:CYCLIC KETALS ARE PRODUCED BY CONTACTING A DEHYDRATING AGENT WITH A COMPOUND OF THE FORMULA: HO-C(-R2)(-R3)-X1-R1-X2H WHEREIN X1 REPRESENTS OXY, THIO, OR NITRILO, WHEREIN X2 REPRESENTS OXY, THIO, OR IMINO, PROVIDED THAT AT LEAST ONE OF X1 AND X2 REPRESENTS OXY, WHEREIN R1 REPRESENTS AN ALKYLENE GROUP OF FROM 2 TO 4 CARBON ATOMS OR A 2BUTYLENE GROUP, AND WHEREIN R2 AND R3 INDIVIDUALLY REPRESENT HALOGENATED ALKYL GROUPS THE ALPHA CARBON ATOMS BEING FLUORO, CHLORO, OR BROMO. THE CYCLIC KETALS PROGROUP, THE REMAINDER OF THE HALO GROUPS ON THE ALKYL BEING FLUORO, CHLORO, OR BROMO. THE CYCLIC KETALS PRODUCED ARE REPRESENTED BY THE FORMULA: R2-C(-R3)<(-O-R4-X1-) WHEREIN X1, R2, AND R3 ARE AS DEFINED ABOVE, AND WHEREIN R4 REPRESENTS ALKYLENE OF 2 TO 4 CARBON ATOMS OR SUBSTITUTED ALKYLENE. THE DEHYDRATING AGENTS EMPLOYED INCLUDE CARBODIIMIDES AND ALPHA-AMINOACETYLENES. THE PROCCESS OF THE INVENTION IS USEFUL FOR THE PREPARATION OF 1,3DIOXOLANES, 1,3 - DIOXANES, 1,3 - DIOXEPANES, AND THEIR ANALOGUES WHEREIN ONE OF THE OXYGEN ATOMS IN THE HETEROCYCLIC RING IS REPLACED BY EITHER A SULFUR ATOM OR NITRILO GROUP.

专利号:US-5312934-A
优先权日:1992-11-30
标 题 :Synthesis of sulfated polyhydroxy fatty acid amide surfactants
发明人：LETTON JAMES C
权利人:PROCTER & GAMBLE
摘要:Polyhydroxy fatty acid amide nonionic surfactants are converted in high yields to their sulfated analog surfactants using an SO3/pyridine complex as a sulfating agent. Thus, C12-C18 N-methyl glucamide is sulfated in methylene chloride or pyridine solvent to form the corresponding sulfated glucamide in yields of 80% or higher.

专利号:US-8519191-B2
优先权日:2009-12-25
标题 :Synthesis method of 3-methylamino-1, 2-propanediol
发明人：ZHANG ZHONGFA; GUO XUEYANG; HUANG HUI
权利人:ZHANG ZHONGFA; GUO XUEYANG; HUANG HUI; WEIFANG PBNS CHEM INDUSTRY CO LTD
摘要:A synthesis method of 3-methylamino-1,2-propanediol is disclosed in the invention, and it includes the following steps: (a) adding glycerin chlorohydrin, aqueous monomethylamine solution and an amination catalyst, namely NaOH solution and NaHCO 3 , into a reactor, mixing the material sufficiently, and allowing amination reaction to proceed in two temperature stages; (b) removing monomethylamine and water from the amination solution after the amination reaction is completed, filtering out the solid resultant, and feeding the filtrate into a still; (c) distilling under reduced pressure to obtain 3-methylamino-1,2-propanediol, wherein the vacuum for distillation under reduced pressure is equal to or greater than 0.099 MPa and the temperature is 130-160° C.

专利号:EP-4520765-A1
优先权日:2023-09-08
标题:Ionizable cationic lipids incorporating silicon
发明人：RÉPÃ?SI JÓZSEF; SZILVÃ?GYI GÃ?BOR
权利人:ALDEXCHEM KFT
摘要:The present invention belongs to the field of biomedicine and drug delivery as well as pest and vector controls.The invention relates to a novel ionizable cationic lipid family incorporating silicon, which belongs to the trademark LipexSil^â„¢ 2^nd generation lipids, wherein the tail is connected to the headgroup with biodegradable silyl acetal linker. Lipids containing silyl acetal linker(s) are state-of-the-art and are effective as ionizable cationic lipids in the formulation of empty or loaded lipid nanoparticles (LNPs). The novel linkers according to the invention are designed by means of proprietary borane catalysts [WO 2022/129966]. The invention describes the synthesis of the lipids of formula (I), formation and characterization of nanoparticles and biological experiments demonstrating that the lipid nanoparticles prepared with these novel lipids can efficiently deliver their cargo (e.g. RNA, DNA, mRNA, siRNA, dsRNA, pDNA, circular DNA, small biologically active molecules) into the cells.