CAS: 53218-26-1; 6-Bromobenzo[d]Thiazole

上下游产品

2-氨基-6-溴苯并噻唑 2-Amino-6-Bromobenzothiazole 15864-32-1
苯并噻唑 1,3-Benzothiazole 95-16-9
6-氨基苯并噻唑 1,3-Benzothiazol-6-Amine 533-30-2

5-Bromo-2-Nitrothiophenol置于palladium On Activated Charcoal,氢气体系中,化学反应生成 6-溴苯并噻唑
参考文献:苯并稠合五元杂环化合物作为具有抗癌活性的微管蛋白聚合抑制剂的设计,合成和生物学评价
标题:苯并稠合五元杂环化合物作为具有抗癌活性的微管蛋白聚合抑制剂的设计,合成和生物学评价
摘要:设计并合成了一系列苯并稠合五元杂环化合物作为靶向秋水仙碱结合位点的新型微管蛋白抑制剂.其中,化合物4D对四种癌细胞系显示出最高的抗增殖活性,在b16-F10细胞中的ic 50值为4.9 μm.化合物 4D 在体外有效抑制微管蛋白聚合(ic 50为 13.1 μm).此外,4D 诱导细胞周期停滞在 G2/m 期.最后,4D 以剂量依赖性方式抑制癌细胞的迁移.总之,这些结果表明化合物 4D 代表了一类新的微管蛋白抑制剂,值得进一步研究.
DOI:10.1111/cbdd.13832

专利信息

专利号:US-3943142-A
优先权日:1969-01-24
标 题:Dye intermediates and their preparation and use in the synthesis of methine dyes
发明人：OWEN JOHN R
权利人:EASTMAN KODAK CO
摘要:Compositions of matter are provided comprising a stable, non-vaporous monomeric methylene base selected from a 2-methylenethiazoline; a 2-methylenebenzothiazoline; a 2-methylenenaphthothiazoline; a 2-methylenebenzoselenazoline; and a 2-methylenenaphthoselenazoline. The compositions of the invention are prepared by reacting the parent 2-methyl quaternary salt with a non-hydroxylic base which removes a proton of the heterocyclic salt together with a proton acceptor which inhibits build-up of the hydro salt of the non-hydroxylic base, the reaction being conducted under anhydrous conditions in a non-hydroxylic liquid in which the heterocyclic quaternary salt is sufficiently insoluble to inhibit dimer formation. The compositions of the invention are employed in the preparation of methine dyes.

专利号:US-2008096883-A1
优先权日:2004-08-11
标题 :Trifluoromethyl substituted benzamides as kinase inhibitors
发明人：CARAVATTI GIORGIO; FURET PASCAL; IMBACH PATRICIA; MARTINY-BARON GEORG; PEREZ LAWRENCE BLAS; SHENG TAO
权利人:CARAVATTI GIORGIO; FURET PASCAL; IMBACH PATRICIA; MARTINY-BARON GEORG; PEREZ LAWRENCE BLAS; SHENG TAO
摘要:The invention relates to trifluoromethyl substituted benzamide compounds of the formula (I), pharmaceuticals comprising these compounds, their use as or for the manufacture of pharmaceuticals, particularly as inhibitors of protein kinases and/or the treatment of a condition, disorder or disease state mediated by a protein kinase activity and/or a proliferative disease, methods of treatment comprising administering the compounds, especially of therapeutic and prophylactic treatment, methods for the manufacture of the compounds and novel intermediates and partial steps for their synthesis.

专利号:CN-114890998-B
优先权日:2022-04-06
标 题 :A kind of synthesis method of photocatalytic amidoalkyl substituted thiazole derivatives

专利号:CN-109338402-A
优先权日:2018-11-29
标题 :A kind of method of electro-catalysis benzo thioamide analog compound synthesis benzothiazole in water

专利号:CN-117658945-A
优先权日:2023-10-20
标题 :Synthesis method of persulfate-induced alkylation modified nitrogen heterocyclic compound

专利号:CN-109293599-A
优先权日:2018-11-29
标 题:A kind of method of microwave radiation benzo thioamide analog compound synthesis benzothiazole in water phase