CAS: 628-87-5; Iminodiacetonitrile

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142-73-4 16728-92-0 74784-64-8

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CAS号74-90-8 氢氰酸 | CAS号100-97-0 乌洛托品 | CAS号109-82-0 亚甲氨基乙腈 | CAS号540-61-4 氨基乙腈 | CAS号2478-50-4 2-aminopentaned... | CAS号107-16-4 羟基乙腈 | CAS号33898-53-2 aziridine-2-car... | CAS号50-00-0 甲醛 | CAS号107-14-2 氯乙腈 | CAS号1116-43-4 2-[(bis(cyanome... | CAS号5994-61-6 双甘膦 | CAS号39987-25-2 氨基双乙酸二甲酯氢氯化物 | CAS号21954-96-1 氨二乙酰胺 | CAS号107-15-3 乙二胺 | CAS号111-40-0 二乙烯三胺 | CAS号110-85-0 哌嗪 | CAS号7327-60-8 2,2,2-氮川三乙腈 | CAS号142-73-4 亚氨基二乙酸 | CAS号7664-41-7 氨

氨基乙腈置于氨体系中,用 水 作为反应溶剂,化学反应 0.33H,反应生成 亚氨基二乙腈
参考文献:Method For Producing Aminonitriles
标题:Method For Producing Aminonitriles
摘要:该发明涉及一种制备氨基腈混合物的方法,包括氨基乙腈(aan)和占重量5%至70%的亚甲基二乙腈(idan),该方法包括将基本不含甲醛氰醇(fach-Free)的粗氨基乙腈加热至50至150oc的温度.

专利信息

专利号:US-2009299067-A1
优先权日:2008-05-30
标 题:New synthesis of 2,6-diamino-3,5-dinitropyrazine-1-oxide from 2,6-diaminopyrazine-1-oxide
发明人：PAGORIA PHILIP F; MITCHELL ALEXANDER R; BALA KASON
权利人:PAGORIA PHILIP F; MITCHELL ALEXANDER R; BALA KASON
摘要:A method for the synthesis of 2,6-Diamino-3,5-dinitropyrazine-1-oxide including nitration of 2,6-diaminopyrazine-1-oxide. The step of nitration may use nitrating agents 20% Oleum/100% HNO3, 100% HNO3 and conc. H2504/100% HNO3 or nitronium tetrfluoraoborate. The synthesis of 2,6-diaminopyrazine-1-oxide may involve both the oxidation of 2,6-diaminopyrazine, the amination of a precursor 2,6-disubstitutedpyrazine-1-oxide or direct formation of the 2,6-diaminopyrazine-l-oxide from the precursor, 2-amino-6-hydroxamino-pyrazine-1-oxide.

专利号:US-10364262-B2
优先权日:2012-07-17
标 题 :Method for the synthesis of N-phosphonomethyliminodiacetic acid
发明人：DEVAUX ALBERT; BURCK SEBASTIAN; NOTTE PATRICK
权利人:MONSANTO TECHNOLOGY LLC
摘要:A method for synthesis of N-phosphonoalkyliminodiacetic acid or derivatives thereof by forming a reaction mixture having an acid catalyst, a compound of the following general formula R1—CH2—NX—CH2—R2 and a compound having one or more P—O—P anhydride moieties to form a compound having a formula R1—CH2—N(—CH2PO3R32)(—CH2—R2) wherein in R1—CH2—NX—CH2—R2: X is —CH2—OH or —CH2—COOH; R1 and R2 are independently selected from the group consisting of nitrile, C1-C4 alkyl carboxylate, and carboxylic acid for when X is —CH2—OH, or R1 and R2 are both carbonyl groups linked by a hydrogen substituted nitrogen atom or a C1-C4-alkyl substituted nitrogen atom; and R3 is H, an alkyl group, or an aryl group; the anhydride moieties in the P—O—P anhydride compound have one P atom at the oxidation state (+III) and one P atom at the oxidation state (+III) or (+V); and 2) hydrolyzing the mixture to form N-phosphonomethyliminodiacetic acid or one of its derivatives.

专利号:US-12428656-B2
优先权日:2020-02-28
标题 :Nitrilase mutant and application thereof in the synthesis of 1-cyanocyclohexyl acetic acid
发明人：XUE YAPING; XIONG NENG; LI QIAN; ZHENG YUGUO
权利人:UNIV ZHEJIANG TECHNOLOGY
摘要:The present invention provides a nitrilase mutant and application thereof in the synthesis of 1-cyanocyclohexyl acetic acid, the nitrilase mutant is obtained by mutating one or two of the amino acids at position 180 and 205 of the amino acid sequence shown in SEQ ID No. 2. In the present invention, by semi-rational design and protein molecular modification, the specific enzyme activity of the nitrilase double mutant AcN-G180D/A205C was increased by up to 1.6 folds, and the conversion rate>99%. And the reaction time was shortened to a quarter of the original using the recombinant Escherichia coli containing the nitrilase mutant to hydrolyze 1-cyanocyclohexylacetonitrile at high temperature (50° C.). Therefore, the mutants obtained by the present invention have a good application prospect in efficiently catalyzing 1-cyanocyclohexylacetonitrile to synthesize gabapentin intermediate, 1-cyanocyclohexyl acetic acid.

专利号:US-6118022-A
优先权日:1998-09-08
标 题 :Synthesis of phosphonomethyliminodiacetic acid with reduced effluent
发明人：CULLEN BARRY A
权利人:HAMPSHIRE CHEMICAL CORP
摘要:A process for the preparation of phosphonomethylglycine in high yields is disclosed. In accordance with the process of the present invention, alkali metal IDA, such as disodium IDA, is reacted with a strong mineral acid, such as HCl, to convert the salt of IDA to IDA. The IDA is then converted to soluble IDA phosphite salt by the addition of phosphorous acid, and the alkali metal salt of the strong acid is precipitated. The phosphite salt of IDA is phosphonomethylated, such as by the addition of PCl3 and formaldehyde. Optionally, phosphorous trichloride can be hydrolyzed to provide the phosphorous acid source for phosphonomethylation of the phosphite salt.

专利号:US-7368492-B2
优先权日:2004-12-22
标题:Process for the synthesis of glycolonitrile
发明人：FOO THOMAS; PANOVA ANNA
权利人:DU PONT
摘要:A process to prepare substantially pure glycolonitrile in an aqueous medium is provided by reacting hydrogen cyanide and formaldehyde. The formaldehyde feed stream is heated prior to reacting with hydrogen cyanide, resulting in an aqueous glycolonitrile solution with fewer impurities, especially less unreacted formaldehyde, than is obtained by other methods. The process enables production of an aqueous glycolonitrile solution that requires less post-reaction purification (if any at all) prior to enzymatically converting the glycolonitrile into glycolic acid.

专利号:US-9458115-B2
优先权日:2009-04-20
标 题 :Synthesis of substituted pyrazines
发明人：PAGORIA PHILIP F; ZHANG MAO XI
权利人:PAGORIA PHILIP F; ZHANG MAO XI; L LIVERMORE NAT SECURITY LLC
摘要:A method for synthesizing a pyrazine-containing material according to one embodiment includes contacting an iminodiacetonitrile derivative with a base and a reagent selected from a group consisting of hydroxylamine, a hydroxylamine salt, an aliphatic primary amine, a secondary amine, an aryl-substituted alkylamine a heteroaryl-substituted alkyl amine, an alcohol, an alkanolamine and an aryl alcoholamine. Additional methods and several reaction products are presented.