5720-06-9 = 766-51-8 + 89694-48-4 反应条件:1.1 Reagents: 1,3-Dichloro-5,5-Dimethylhydantoin Solvents: Acetonitrile; Rt; Rt -> 60 °C; 8 - 16 H,60 °C; 60 °C -> Rt1.2 Reagents: Sodium Sulfite Solvents: Water; Rt 标题:Facile Synthesis Of 2-Bromo-3-Fluorobenzonitrile: An Application And Study Of The Halodeboronation Of Arylboronic Acids 作者:Szumigala,Ronald H. Jr.; Devine,Paul N.; Gauthier,Donald R. Jr.; Volante,R. P. 参考文献:Journal Of Organic Chemistry 日期:2004 卷标:69(2) 页码:566-569
2-硝基苯甲醚置于苯基二氯化磷体系中,用 Various Solvent(S) 作为反应溶剂,化学反应 5.0H,以66%的收率获得产物2-氯苯甲醚 参考文献:A Simple Direct Procedure For The Regiospecific Preparation Of Chloro Aromatic Compounds 标题:A Simple Direct Procedure For The Regiospecific Preparation Of Chloro Aromatic Compounds 摘要: DOI:10.1021/jo00247A042
专利号:US-2013184465-A1 优先权日:2010-09-30 标 题:Process for the synthesis of thio-triazolo-group containing compounds 发明人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL 权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE 摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.
专利号:US-6048991-A 优先权日:1990-11-16 标题:Preparation of epoxides 发明人:HAERMELING DIETER 权利人:BASF AG 摘要:Alpha-hydroxy-epoxides of alpha-alkoxy-epoxides of the formula IV ##STR1## in which the substituents have the following meanings: R 7 , R 8 , R 9 , R 10 , R 11 are independently hydrogen, C 1 -C 20 -alkyl, C 3 -C 12 -cycloalkyl, C 4 -C 20 -cycloalkylalkyl, C 1 -C 20 -hydroxy-alkyl, a heterocyclic ring, or an aryl or C 7 -C 20 -arylalkyl group optionally substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, halogen, C 1 -C 4 -haloalkyl, C 1 -C 4 -halo-alkoxy, phenyl, phenoxy, halophenyl, halophenoxy, carboxy, C 2 -C 8 -alkoxycarbonyl, or cyano, or R 7 and R 8 or R 7 and R 9 or R 7 and R 10 or R 9 and R 10 or R 10 and R 11 together form a (CH 2 ) n group in which n is an integer from 1 to 10 and which may be optionally substituted by C 1 -C 8 -alkyl, C 1 -C 8 -alkoxy, and/or halogen, and n R 12 is hydrogen, C 1 -C 8 -alkyl, or benzyl, n provided that R 10 is not hydrogen, methyl, ethyl, propyl, or cyclohexyl when R 7 , R 8 , R 9 , or R 11 is hydrogen, that R 7 is not methyl when R 8 is methyl or phenyl and R 9 , R 10 , or R 11 is hydrogen, that R 7 is not methyl when R 8 , R 9 , R 10 , or R 11 is hydrogen and R 12 is ethyl, that R 7 is not phenyl or hexyl when R 8 , R 9 , R 10 , or R 11 is hydrogen, that R 9 is not methyl when R 7 , R 8 , R 10 , or R 11 is hydrogen, that R 10 and R 11 are not methyl when R 7 , R 8 , or R 9 is hydrogen, and that R 7 and R 10 do not together form an unsubstituted cycloalkyl when R 8 , R 9 , or R 11 is hydrogen. The epoxides of the above formula serve as intermediates for the synthesis of, inter alia, perfumes, plant protectants and polymers.
专利号:US-9949970-B2 优先权日:2010-09-14 标题 :Synthesis of new benzothiazole derivatives as potential anti-tubercular agents 发明人:KAMAL AHMED; SHETTI RAJESH VCRNC; SWAPNA PONNAMPALLI; AZEEZA SHAIK; REDDY A MALLA; KHAN INSHAD ALI; ABDULLAH SHEIKH TASDUQ; SHARMA SANDEEP; KALIA NITIN PAL 权利人:COUNCIL SCIENT IND RES 摘要:Disclosed are compounds of general formula A useful as potential anti-tubercular agents. The general formula A is
专利号:US-5098602-A 优先权日:1988-05-11 标题 :Novel halogen-containing ester compounds, and their intermediates, and method of producing the same as well as liquid crystal compositions containing the same and light switching elements 发明人:HIRAI TOSHIHIRO; YOSHIZAWA ATSUSHI; NISHIYAMA ISA; FUKUMASA MITSUO; SHIRATORI NOBUYUKI; YOKOYAMA AKIHISA 权利人:NIPPON MINING CO 摘要:This invention provides a novel halogen-containing ester compound represented by the following general formula (I): ##STR1## (wherein R is an alkyl group, A is selected from a single bond, --O--, --COO-- and --CO--, both of X and Y are halogen atoms or either one of X and Y is a halogen atom and the other is a hydrogen atom, each of m and n is 0 or 1, m+n=0 or 1, each of k and l is an integer of 1 or more, provide k 专利号:US-4758661-A 优先权日:1986-06-24 标题 :Chiral synthesis of (+)-trans-1a,2,3,4a,5,6-hexahydro-9-hydroxy-4-propyl-4H-naphth[1,2-b]-1,4-oxazine 发明人:MELILLO DAVID G; MATHRE DAVID J; LARSEN ROBERT D 权利人:MERCK & CO INC 摘要:(+)-trans-1a,2,3,4a,5,6-Hexahydro-9-hydroxy-4-propyl-4H-naphth[1,2-b]-1,4-oxazine is elaborated by a series of process steps that retain the enantiomeric purity of the starting material, D-aspartic acid. The product is a direct acting dopaminergic agent, useful in the treatment of Parkinson's disease.
专利号:US-8114993-B2 优先权日:2007-02-06 标题:Use of aryl chlorides in palladium-catalyzed C-H bond functionalization 发明人:DAUGULIS OLAFS; CHIONG HENDRICH 权利人:DAUGULIS OLAFS; CHIONG HENDRICH; UNIV HOUSTON SYSTEM 摘要:A one-step method for efficiently converting carbon-hydrogen bonds into carbon-carbon bonds using chloroarenes and palladium catalysts is disclosed. This method allows faster introduction of complex molecular entities, a process that would otherwise require many more steps. This invention is particularly relevant for the organic synthesis of complex molecules such as, but not limited to, pharmacophores.
[参考文献]: Keith Smith, Et Al. Acetylation Of Aromatic Ethers Using Acetic Anhydride Over Solid Acid Catalysts In A Solvent-Free System. Scope Of The Reaction For Substituted Ethers. Org Biomol Chem. 2003 May 7;1(9):1560-4.
合成参考文献
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