CAS: 87-81-0; (3S,4S,5R)-1,3,4,5,6-Pentahydroxyhexan-2-One

相似化合物

7776-48-9 551-68-8 17598-82-2

上下游产品

CAS号2595-98-4 D-(+)-塔洛糖 | CAS号59-23-4 半乳糖 | CAS号67-47-0 5-羟甲基糠醛 | CAS号643-03-8 D-塔罗糖醇 | CAS号608-66-2 卫矛醇 | CAS号87-79-6 L-山梨糖 | CAS号57-48-7 果糖

Methyl 3,4-O-Isopropylidene-β-D-Tagatopyranoside置于溶剂黄146体系中,化学反应 0.17H,以100%的收率获得产物d-塔格糖
参考文献:由d-半乳糖衍生物合成d-塔格糖和1,5-脱水-D-塔格糖.
标题:由d-半乳糖衍生物合成d-塔格糖和1,5-脱水-D-塔格糖.
摘要:通过3,4,6-保护的d-吡喃半乳糖苷的氧化反应制得的3,4-O-异亚丙基-D-Lyxo-己吡喃糖苷-2-Ulose衍生物可以阴离子2,6-吡喃糖形式烷基化反应生成双-含2,5-二氧杂双环[2.2.2]辛烷环系统的糖苷.1-苄基-2-甲基双糖苷4B在进行催化氢解后,反应生成甲基d-Lyxo-己吡喃并-2-Uloside 10,以1:5-吡喃糖异构体9:8的混合物形式存在.计算并提供了NMR证据,以支持主要端基异构体具有α构型的假设.用nabh4还原9/10可得到甲基3,4-O-异亚丙基-β-D-塔格吡喃糖苷,可以水解为d-塔格糖.还介绍了从1,5-脱水d-半乳糖醇开始的1,5-脱水d-塔格糖的简单合成.
DOI:10.1016/0008-6215(95)00125-D

专利信息

专利号:US-2022395800-A1
优先权日:2019-11-04
标题:Device for automated synthesis of oligo- and polysaccharides
发明人：SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO
权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A
摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.

专利号:US-2019315790-A1
优先权日:2016-11-11
标题:Synthesis of d-allulose
发明人：KOCH TIMO JOHANNES; KIPPING FLORIAN; BUTZ STEFFEN; LESCH MARCEL; HÄSSLER THOMAS
权利人:PFEIFER & LANGEN GMBH & CO KG
摘要:The invention relates to a process for the synthesis of a product saccharide, preferably of D-allulose from an educt saccharide, preferably from D-fructose under heterogeneous or homogeneous catalysis which includes chemical and/or enzymatic catalysis. The synthesis is performed in at least two reactors that are arranged in series and the reaction product exiting the first reactor is subjected to chromatographic separation before it enters the second reactor. Preferably, the chromatographic separation is integrated in a simulated moving bed.

专利号:US-10005807-B2
优先权日:2013-04-12
标题 :Synthesis of sialylated/fucosylated human milk oligosaccharides
发明人：CHASSAGNE PIERRE; KHANZHIN NIKOLAY; HEDEROS MARKUS JONDELIUS; CHAMPION ELISE; MATWIEJUK MARTIN; DEKANY GYULA
权利人:GLYCOM AS
摘要:An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N 3 and —OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH 2) n —NH 2 and —(CH 2) n —N 3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO 3 H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that at least one of R 3 and R 4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

专利号:WO-9516049-A1
优先权日:1993-12-08
标题 :Catalytic chemo-enzymatic asymmetric synthesis of carbohydrates
发明人：WONG CHI-HUEY; SHARPLESS BARRY K
权利人:SCRIPPS RESEARCH INST; WONG CHI HUEY; SHARPLESS BARRY K
摘要:A stereoselective synthesis of carbohydrates employs two key stereoselective steps, viz. an osmium-catalyzed asymmetric dihydroxylation (AD) of an alkene to form an aldol intermediate and an aldolase-catalyzed aldol addition reaction wherein the aldol intermediate is elongated by the addition of a ketone. Moreover, ketoses having four new stereocenters can be synthesized without the use of chiral starting materials. The stereoselectivity of the asymmetric dihydroxylation (AD) reaction is determined by the cis or trans (Z or E) stereoisomeric configuration of the alkene and by the choice of AD-mix, i.e., an AD-mix-α or AD-mix-β. The stereoselectivity of the aldolase-catalyzed addition reaction is determined by the choice of aldolase and by the stereochemistry of the aldol intermediate. Four aldolases with broad substrate specificity are sufficient to produce all possible enantiomeric combinations of the two hydroxymethylene stereocenters formed during the aldol addition reaction. Accordingly, a synthetic scheme combining an osmium-catalyzed asymmetric dihydroxylation (AD) reaction and an aldolase-catalyzed aldol addition reaction enables direct access to a wide range of carbohydrate derivatives containing up to four new hydroxymethylene stereocenters.

专利号:WO-2014167537-A1
优先权日:2013-04-12
标题:Synthesis of sialylated/fucosylated oligosaccharides
发明人：KHANZHIN NIKOLAY; CHASSAGNE PIERRE; HEDEROS MARKUS; CHAMPION ELISE; MATWIEJUK MARTIN; DEKANY GYULA
权利人:GLYCOM AS
摘要:This invention relates to a chemo-enzymatic synthesis of oligosaccharidesof formula 1 wherein R is selected from -OH, -N 3 and -OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, -(CH 2 ) n -NH 2 and -(CH 2 ) n -N 3 wherein integer n is to 10, preferably 2 or 3, R 1 is selected from sialyl moiety, -SO 3 H and -CH(R 5 )-COOH wherein R 5 is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that one but only one of R 3 and R 4 is H, and A is selected from a bond and a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

专利号:EP-3835306-A1
优先权日:2019-12-13
标题:Microwave-assisted method for synthesis of oligo- and polysaccharides on solid phase
权利人:MAX PLANCK GESELLSCHAFT
摘要:The present invention relates to a method for synthesizing oligo- and polysaccharides using microwave radiation, in particular to a method and a device for automated synthesis of oligo- and polysaccharides.