盐酸阿米替林置于potassium Permanganate,Sodium Hydroxide体系中,用 水 用作溶剂,化学反应生成10,11-二氢二苯并[a,B]环庚烯-5-酮 参考文献:Spectrophotometric Determination Of Amitriptyline Hcl In Pure And Pharmaceutical Forms 标题:Spectrophotometric Determination Of Amitriptyline Hcl In Pure And Pharmaceutical Forms 摘要: Doi:10.4067/s0717-97072014000100005
专利号:US-9929363-B2 优先权日:2013-08-05 标题:Composition and synthesis of aggregation-induced emission materials 发明人:TANG BENZHONG; Xie ni; LAM WING YIP 权利人:UNIV HONG KONG SCI & TECH 摘要:The present subject matter relates to compositions containing and synthesis of fluorescent materials e made from tetraphenylethylene (TPE) derivative compounds exhibiting aggregation induced emission (AIE) properties. Further contemplated herein are applications for TPE derivative compounds such as electroluminescent devices since they have a high efficiency, low turn on voltage, and excellent brightness. Additionally, application of TPE derivatives exhibiting AIE properties in various fields such as OLEDs, fingerprinting and forensic technology, and various other biological and industrial sectors are discussed.
专利号:US-4443310-A 优先权日:1981-03-12 标题:Photoinitiated synthesis of mercaptans 发明人:ARRETZ EMMANUEL; LANDOUSSY CLAUDE; MIRASSOU ALFRED; OLLIVIER JEAN 权利人:ELF AQUITAINE 摘要:Improvement in the photoinitiated synthesis of mercaptans, in which an ethylenic compound is treated with hydrogen sulphide, preferably under pressure, in the presence of ultraviolet radiation and a photoinitiator involves the use of a xanthenic compound, possibly substituted, as the initiator. Preferably, the xanthenic compounds is employed in conjunction with an organic compound of an element of Group V A of the Periodic Classification of the Elements.
专利号:US-12006541-B2 优先权日:2021-05-07 标题:Methods and apparatuses for generating peptides by synthesizing a portion of a design space to identify peptides having non-canonical amino acids 发明人:LEE FRANCIS; STECKBECK JONATHAN D; HOLSTE HANNES 权利人:PEPTILOGICS INC C; PEPTILOGICS INC 摘要:In one aspect, a computer-implemented automated flow synthesis platform configured to use an artificial intelligence (AI) engine is disclosed and includes a reaction chamber configured to synthesize a sequence, detectors configured to monitor the synthesis of the sequence in the reaction chamber, wherein the synthesis uses an automated flow process, and a computing device communicatively coupled to the detectors. The computing device receives measurements from the one or more detectors, wherein the measurements comprise a spectral profile at each coupling of each amino acid in the sequence, trains, using training data comprising the measurements, machine learning models to determine a synthesizing recipe that enables the sequence to be synthesized, wherein the synthesizing recipe comprises parameters used during the automated flow process to synthesize the sequence, and controls, using the synthesizing recipe, the synthesis of the sequence in the reaction chamber.
专利号:US-9573873-B2 优先权日:2014-06-03 标题:Catalytic method for dibenzocycloheptane synthesis and allocolchicinoid synthesis 发明人:GREEN JAMES; MEHDI MARIAM; DJURDJEVIC SINISA 权利人:UNIV OF WINDSOR 摘要:In a non-limiting embodiment, there is provided a compound of formula (I), which may permit for a method or use in treating or preventing a cancer, such as pancreatic cancer or leukemia. In one embodiment, there is also provide a method of preparing a compound of formula (Ia), the method including conducting a cyclization reaction of a compound of formula (III) to obtain a compound of formula (IV), wherein conducting the cyclization reaction comprises conducting a Michael reaction in the presence of a Lewis acid.
专利号:WO-2024134480-A1 优先权日:2022-12-21 标题:Heterocyclic acrylic acid derivatives as monomers for the synthesis of polymers for use in ion exchange articles 发明人:RASMUSSEN JERALD K; HOCHSTEIN REBECCA A; FISHMAN JOSHUA M; VOLOSHIN ALEXEI M; WATTS ANNABELLE; RICHARDSON KRISTOPHER E; BISHOP LOGAN D C; GRIESGRABER GEORGE W; WLASCHIN KATIE F; COLAK ATAN SEMRA; JULIK EMILY; VAIL ANDREW W 权利人:3M INNOVATIVE PROPERTIES COMPANY 摘要:The present invention relates to monomers of formula (I) having a nitrogen atom that can be protonated at relatively low pH values (e.g., less than pH 9.5 or less than pH 9), polymers containing monomeric units derived from these monomers, anion exchange separation articles having the polymers grafted to a porous substrate, and methods of using the anion separation articles to separate mixtures of materials with different ionic content are described. Advantageously, the anion exchange separation articles can be used to separate biomaterials that cannot be subjected to high pH conditions (e.g., greater than 9 or 9.5) and/or to high ionic strength conditions (e.g., greater than 0.5M or 1M).
专利号:US-2014309437-A1 优先权日:2013-04-11 标 题 :Process for the preparation of pharmaceutical intermediates 发明人:ARTICO MARCO; ATTOLINO EMANUELE 权利人:DIPHARMA FRANCIS SRL 摘要:Process for the preparation of intermediates that are useful in the synthesis of active pharmaceutical ingredients (API), in particular active in the central nervous system.
参考标题:Neutral Dinuclear Copper(I)-Nhc Complexes: Synthesis And Application In The Hydrosilylation Of Ketones 作者:Michael Trose,Faïma Lazreg,Tao Chang,Fady Nahra,David B. Cordes,Alexandra M. Z. Slawin,Catherine S. J. Cazin |发布日期:2017.1.6 摘要:The Synthesis Of A Class Of Highly Stable Neutral Dinuclear Cu(I)-Nhc Complexes Using 1,2,4-Triazole As A Bridging Ligand Is Described. Various Nhcs Were Used To Generate A Library Of [cu(μ-Trz)(Nhc)]2 Complexes. Interestingly, [cu(μ-Trz)(Ipr)]2 Was Found To Be Highly Active In The Hydrosilylation Of Ketones, Without The Need For An External Base Or Any Other Additive. A Wide Range Of Aryl And Alkyl
合成参考文献
摘要:Toyota, S.; Iwanaga, T., Science of Synthesis, (2010) 45, 800. 摘要:Chemla, F.; Ferreira, F.; Pérez-Luna, A., Science of Synthesis Knowledge Updates, (2012) 1, 464. 摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/U_schafer041_2004.pdf