CAS: 24019-66-7; 3-Allyl-2-Hydroxybenzaldehyde

上下游产品

hexamethylenetetramine o-Allylphenol 2-(allyloxy)benzaldehyde formaldehyd H-chromene-3-carboxylic acid8-allyl-2-oxo-2H-chromene-3-carboxylic acid 3-allyl-5-nitrosalicylaldehyde 3-allyl-2,5-dihydroxy-benzaldehyde 4-(3-allyl-2-hydroxy-benzylidene)-1,2-diphenyl-pyrazolidine-3,5-dione

2-烯丙基酚置于magnesium Chloride,三乙胺,Paraformaldehyde体系中,用 乙腈 用作溶剂,以68%的收率获得3-烯丙基-2-羟基苯甲醛
参考文献:Substituted Hydrazide Compounds And Use Thereof
标题:Substituted Hydrazide Compounds And Use Thereof
摘要:本发明涉及通式i所示的取代肼化合物,包括几何异构体,药学上可接受的盐,水合物,溶剂合物或前药,以及其使用,其中取代基ar和r的含义与说明中给出的相同.本发明还涉及通式i化合物在制备用于治疗和/或预防癌症和其他增殖性疾病的药物中的使用.

专利信息

专利号:US-9663482-B2
优先权日:2012-08-03
标 题:Substituted piperazinyl acetohydrazide procaspase-activating compounds
发明人：HERGENROTHER PAUL J; ROTH HOWARD S
权利人:UNIV ILLINOIS
摘要:The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds are of Formula I n nThe compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

专利号:US-2014315915-A1
优先权日:2009-02-09
标题:Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs

专利号:US-9522901-B2
优先权日:2005-05-26
标题:Compositions and methods including cell death inducers and procaspase activation
发明人：HERGENROTHER PAUL J; PUTT KARSON S; PETERSON QUINN P; FAKO VALERIE
权利人:UNIV ILLINOIS
摘要:Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.

专利号:US-9643960-B2
优先权日:2009-02-09
标 题:Procaspase activating compounds
发明人：HERGENROTHER PAUL J; PETERSON QUINN PATRICK; HSU DANNY CHUNG; WEST DIANA C; FAN TIMOTHY M; NOVOTNY CHRIS J
权利人:UNIV ILLINOIS
摘要:Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed that have lower neurotoxicity effects than other compounds.

专利号:US-2012040995-A1
优先权日:2009-02-09
标 题:Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs

专利号:AU-2010210403-A1
优先权日:2009-02-09
标 题 :Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs