CAS: 3147-64-6; 2-Hydroxy-6-Methoxybenzoic Acid

上下游产品

2,6-二甲氧基苯甲酸 2-6-Dimethoxybenzoic Acid 1466-76-8
邻甲氧基苯甲酸 2-Methoxybenzoic Acid 579-75-9
2,6-二甲氧基苯甲酸甲酯 Methyl 2,6-Dimethoxybenzoate 2065-27-2
2,6-二羟基苯甲酸 2,6-Dihydroxybenzoic Acid 303-07-1
1-(2-羟基-6-甲氧基苯基)乙基-1-酮 2'-Hydroxy-6'-Methoxyacetophenone 703-23-1

邻甲氧基苯甲酸置于叔丁基过氧化氢,N-乙酰-L-异亮氨酸,Potassium Acetate,Palladium Diacetate,对苯醌体系中,用 乙二醇二甲醚,水 作为反应溶剂,以78%的收率获得产物6-甲氧基水杨酸
参考文献:钯催化的苯甲酸邻位 Ch 羟基化
标题:钯催化的苯甲酸邻位 Ch 羟基化
摘要:已经探索了使用 Tbhp 作为唯一氧化剂的简单 Pd(Oac) 2催化苯甲酸邻羟基化反应.该协议具有相对广泛的基板范围和操作简单性.邻位取代底物的相容性是对先前邻位羟基化反应的有效补充.
DOI:10.1016/j.Tetlet.2021.153434

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-9453037-B2
优先权日:2011-07-28
标 题 :Methylphenidate-prodrugs, processes of making and using the same
发明人：GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB
权利人:KEMPHARM INC; KEMPHARM INC
摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.

专利号:US-5608074-A
优先权日:1993-12-03
标 题:Process for the synthesis of 5-amino tetrazole derivatives
发明人：WALKER JONATHAN
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of 3-chlorobenzo[b]thiophene-2-carbonyl chlorides is described where a cinnamic acid is converted in the presence of thionyl chloride and a 4-N,N'-disubstituted aminopyridine in one step to the desired product.

专利号:WO-2011158333-A1
优先权日:2010-06-15
标题 :Zederone analogue and method for synthesizing same
发明人：SUETSUGU KAZUHIRO; MORITA SATOSHI; YAMADA YASUHIRO; OHNO TOSHINOBU; ITO TAKATOSHI; IWAI TOSHIYUKI; MATSUMOTO FUKASHI
权利人:NARIS COSMETICS CO LTD; OSAKA MUNICIPAL TECH RES INST; SUETSUGU KAZUHIRO; MORITA SATOSHI; YAMADA YASUHIRO; OHNO TOSHINOBU; ITO TAKATOSHI; IWAI TOSHIYUKI; MATSUMOTO FUKASHI
摘要:The present invention provides a method for synthesizing a zederone analogue derived from natural materials, a precursor useful in synthesis of the zederone analogue, and an intermediate useful for synthesizing the zederone precursor. Specifically, the present invention uses (E) -5-halegeno-4-hexanoic acid alkyl ester as a starting material to synthesize a zederone analogue, a precursor useful in synthesis of the zederone analogue, and an intermediate useful for synthesizing the zederone precursor.

专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same