专利号:US-2004058888-A1 优先权日:2000-01-13 标题:Methods for synthesis of alpha-d-gal (1~>3) gal-containing oligosaccharides 发明人:BORNAGHI LAURENT; DEKANY GYULA; DRINNAN NICHOLAS BARRY; PAPAGEORGIOU JOHN; WEST MICHAEL LEO 摘要:This invention relates to reagents and methods for synthesis of biologically active di- and tri-saccharides comprising α-D-Gal(1→3)-D-Gal. In particular the invention provides novel reagents, intermediates and processes for the solution or solid phase synthesis of α-D-galactopyranosyl-(1→3)-D-galactose, and derivatives thereof. In one preferred embodiments the invention provides a protected monosaccharide building block of general formula (II): in which R 3 is methoxy or methyl; R 1 is H, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl; and R 2 is H, Fmoc, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4 -chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl.
专利号:US-11434209-B2 优先权日:2018-08-21 标 题 :Method for synthesis of TKX-50 using insensitive intermediate 发明人:KWON KUK TAE; LEE WOONG HEE; SHIM JEONG SUB; LEE SO JUNG 权利人:AGENCY DEFENSE DEV 摘要:The present disclosure relates to a method for synthesis of TKX-50 using an insensitive intermediate, and more specifically, to a method of manufacturing TKX-50 which includes: preparing DCG as a starting material; forming a THP-DAG intermediate from the DCG; and synthesizing TKX-50 through the THP-DAG intermediate.
专利号:US-6813597-B1 优先权日:1999-06-18 标 题:Mixed signal synthesis 发明人:DEMLER MICHAEL J 权利人:CADENCE DESIGN SYSTEMS INC 摘要:Method and apparatus for the synthesis of electronic circuits and, more particuarly, to the synthesis of analog circuitry and mixed digital and analog circuitry, and related to the reuse of circuit designer knowledge for the simulation of mixed analog and digital circuitry to determine data points and to curve fit the data points to determine a polynomial equation that closely approximates simulated circuit performance, and related to the parameterization of circuit features with respect to circuit performance.
专利号:US-6127536-A 优先权日:1999-05-25 标题:Synthesis of a tetraamido macrocycle ligand 发明人:DELINE JAMES E; OTT MICHAEL M; KLOTTER KEVIN A 权利人:CLOROX CO 摘要:An improved synthesis for preparing a tetraamido-macrocyclic ligand, such as 5,6-Benzo-3,8,11,13-tetraoxo-2,2,9,9-tetramethyl-12,12-diethyl-1,4,7,10-tetraazacyclotridecane, H 4 , in greatly improved yield and in a commercially viable manner, comprising the steps of dissolving a quantity of a 1,2-bis(2-aminoalkanamido)benzene in a solution comprised of ethyl acetate and methylene chloride to yield a first reaction solution; dissolving a quantity of a malonyl dihalide in an ethyl acetate solution to yield a second reaction solution; adding the first reaction solution and the second reaction solution to a reaction vessel containing a third reaction solution comprised of refluxing ethyl acetate solution and an acid scavenger to form a reaction mixture; and isolating a solid product comprised of the tetraamido-macrocycle directly from the reaction mixture by filtration.
专利号:US-5446186-A 优先权日:1993-11-09 标 题:Structure and synthesis of nitrophenyl-EGTA, a caged calcium, intermediates thereof and a method of producing a high photochemical yield of liberated calcium 发明人:ELLIS-DAVIES GRAHAM C R; KAPLAN JACK H 摘要:The synthesis and compound of a new caged calcium which is an ortho-nitrophenyl derivative of EGTA and various intermediates. It is synthesized in ten steps and 24% overall yield. The photosensitive chelator, nitrophenyl-EGTA, has a K d for Ca 2+ of 80 nM and for Mg 2+ of 8.8 mM. Upon exposure to ultra-violet light (in the region of 350 nm), the chelator is cleaved, yielding iminodiacetic acid photoproducts with known low Ca-affinity (K d =1 mM). The quantum yield of photolysis of nitrophenyl-EGTA in the presence of Ca a+ is 0.23 and in the absence of Ca 2+ is 0.20. In experiments with chemically skinned skeletal muscle fibers, a fully relaxed fiber equilibrated with nitrophenyl-EGTA:Ca 2+ complex, in the presence of physiological [Mg 2+ ] (i.e. 1.0 mM), produced maximal contraction after a single flash from a frequency doubled ruby laser (347 nm). Half-maximal tension was achieved in 18 ms at 15° C. Nitrophenyl-EGTA provides a new tool for the investigation of the mechanism of Ca 2+ -dependent physiological processes, since under conditions of normal intracellular Ca 2+ and Mg 2+ ions, only Ca 2+ ions are bound by the photolabile chelator and on illumination are released rapidly and in high photochemical yield.
专利号:US-6521664-B1 优先权日:1999-12-08 标 题:Pesticidal activity of functionalized alkenes 发明人:LINDERMAN RUSSELL J 权利人:UNIV NORTH CAROLINA STATE 摘要:The present invention provides non-peptide organic compounds that have a structure analogous to or reminiscent of the TMOF structure and have pesticidal activity. Thus the present invention concerns pesticidal compounds that inhibit digestion in pests by terminating or otherwise blocking synthesis of digestive enzymes by activating a TMOF receptor (collectively referred to herein as “pesticidal compoundsâ€?). The pesticidal compounds and other compounds of the present invention are usefully employed in the control of pests, particularly insect pests such as mosquitoes, which ingest blood.
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