CAS: 40137-29-9; 4-Chloro-2-Methylbenzaldehyde

上下游产品

4-dichloromethyl-4-methyl-2,5-cyclohexadienone formaldoxime 4-chloro-2-methylbenzeneamine 4-chloro-1,2-dimethylbenzene 3-(4-chloro-2-methyl-phenyl)-glutaric acid benzamineN-(4-chloro-2-methylphenyl)methylenebenzamine 4-chloro-2-methylbenzaldehyde ethylene acetal 2-methyl-4-chlorobenzyl alcohol

4-二氯甲基-4-甲基-2,5-环己烷二酮置于五氯化磷体系中,化学反应生成 4-氯-2-甲基苯甲醛
参考文献:Auwers; Keil,Chemische Berichte,1905,Vol. 38,P. 1693
标题:Auwers; Keil,Chemische Berichte,1905,Vol. 38,P. 1693

专利信息

专利号:US-4710513-A
优先权日:1979-08-17
标 题:Substituted pyranone inhibitors of cholesterol synthesis
发明人：WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J
权利人:MERCK & CO INC
摘要:6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

专利号:US-4459422-A
优先权日:1979-08-17
标 题:Substituted pyranone inhibitors of cholesterol synthesis
发明人：WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J
权利人:MERCK & CO INC
摘要:6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

专利号:US-4375475-A
优先权日:1979-08-17
标 题 :Substituted pyranone inhibitors of cholesterol synthesis
发明人：WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J
权利人:MERCK & CO INC
摘要:6-Phenyl-, phenylalkyl- and phenylethenyl-4-hydroxytetrahydropyran-2-ones in the 4(R)-trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

专利号:WO-2022200444-A1
优先权日:2021-03-24
标 题:New process for the synthesis of 5-{5-chloro-2-[(3n)-3- [(morpholin-4-yl)methyl]-3,4-dihydroisoquinoline-2(1h)- carbonyl]phenyl}-1,2-dimethyl-1h-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds

专利号:US-4567289-A
优先权日:1979-08-17
标 题 :Substituted pyranone inhibitors of cholesterol synthesis
发明人：WILLARD ALVIN K; NOVELLO FREDERICK C; HOFFMAN WILLIAM F; CRAGOE JR EDWARD J
权利人:MERCK & CO INC
摘要:The methyl, ethyl, n-propy, 2-(acetylamino)ethyl, or 1-(2,3-dihydroxy)propyl ester of E-(3R,5S)-7-(4'-fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl)-3,5-dihyd roxy-6-heptenoic acid of structural formula: are HMG-CoA reductase inhibitors useful in the treatment of conditions associated with hypercholesterolemia.

专利号:US-9657037-B2
优先权日:2013-06-03
标 题:Pyrrole compounds with silicon incorporation
发明人：REDDY DUMBALA SRINIVASA; VASUDEVAN NATARAJAN; WAGH SACHIN BHAUSAHEB; RAMESH REMYA
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses novel Silicon incorporated pyrrole compounds of Formula I having potential anti-bacterial properties. The invention further discloses a process for synthesis of pyrrole compounds with silicon incorporation of Formula I and to the pharmaceutical composition thereof.