CAS: 42461-84-7; (2R,3R,4R,5S)-6-(Methylamino)Hexane-1,2,3,4,5-Pentaol 2-((2-Methyl-3-(Trifluoromethyl)Phenyl)Amino)Nicotinate

上下游产品

1-deoxy-1-(methylamino)-D-glucitol flunixin

N-甲基-D-葡胺,氟尼克辛置于maltodextrin体系中,用 异丙醇 作为反应溶剂,化学反应生成 氟胺烟酸葡甲胺盐
参考文献:一种氟尼辛葡甲胺的制备方法
标题:一种氟尼辛葡甲胺的制备方法
摘要:本发明公开了一种氟尼辛葡甲胺的制备方法,具体过程如下:(1)将2‑氯烟酸与2‑甲基‑3‑三氟甲基苯胺加入氢氧化钠水溶液中搅拌,加入乙二醇以及相转移催化剂和对甲苯磺酸及氧化铜,控制温度,时间,调节溶液ph,搅拌后静置分层,搅拌后过滤,洗涤滤饼,干燥得氟尼辛;(2)将步骤(1)中所得氟尼辛与n－甲基葡萄糖胺在异丙醇中进行反应,同时加入填充剂;加热回流,过滤,降温,搅拌结晶,晶体抽滤经异丙醇洗涤得到氟尼辛葡甲胺.本发明提供的一种氟尼辛葡甲胺的制备方法,操作方便简单,反映高效,反应温度低,反应时间短,成本低;并且制得的氟尼辛葡甲胺的纯度高,收率高.

专利信息

专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人：PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.

专利号:US-5914322-A
优先权日:1992-02-20
标 题:Treatment of disease and conditions
发明人：FALK RUDOLF EDGAR; ASCULAI SAMUEL SIMON
权利人:HYAL PHARMA CORP
摘要:A topically applied transdermally penetrating systemic independent acting pharmaceutical combination and formulation for the treatment of a disease or condition of the skin and exposed tissue for example, basal cell carcinoma, the precancerous, often recurrent, actinic keratoses lesions, fungal lesions, 'liver' spots and like lesions (found for the most part in the epidermis), squamous cell tumours, metastatic cancer of the breast to the skin, primary and metastatic melanoma in the skin, genital warts (condyloma acuminata) cervical cancer, and HPV (Human Papilloma Virus) including HPV of the cervix, psoriasis (both plaque-type psoriasis and nail bed psoriasis), corns on the feet and hair loss on the head of pregnant women, comprising, together with pharmaceutical excipients suitable for topical application, a therapeutically effective non-toxic amount of a drug which inhibits prostaglandin synthesis administered with, or carried in, an amount of hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments, and/or sub-units of hyaluronic acid (preferably hyaluronic acid and salts thereof) sufficient to facilitate the drug's penetration through the skin and tissue (including any scar tissue) at the site requiring treatment, to block prostaglandin synthesis.

专利号:US-5792753-A
优先权日:1991-07-03
标 题:Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
发明人：FALK RUDOLF EDGAR; ASCULAI SAMUEL SIMON
权利人:HYAL PHARMA CORP
摘要:A topically administrable pharmaceutical composition is disclosed which comprises a therapeutically effective amount of a drug which inhibits prostaglandin synthesis, and an amount of a form of hyaluronic acid sufficient to transport the composition through the skin into the epidermis or dermis where the composition remains until discharged via the lymphatic system, wherein n (a) the drug is 1-5% by weight of the composition, and n (b) the form of hyaluronic acid is 1-3% by weight of the composition, has a molecular weight greater than about 150,000 daltons and less than 750,000 daltons, and is selected from the group consisting of hyaluronic acid and salts thereof.

专利号:WO-2023096715-A9
优先权日:2021-10-22
标 题:Immunomodulatory glycosphingolipids and methods of use thereof
发明人：KASPER DENNIS; OH SUNGWHAN
权利人:HARVARD COLLEGE
摘要:Provided herein are a subset of alpha-galactosylceramide (alpha-GC) compounds having improved immunomodulatory activity, particularly with respect to NKT cell number and activity. Also provided herein are methods of use of such compounds, including in the modulation of NKT cells and/or activity in vivo. Further provided are combinatorial synthesis methods for generating alpha-GC compounds of specifically defined structure and thereby generating pure preparations thereof.

专利号:US-2022125838-A1
优先权日:2019-02-11
标题 :Immunomodulatory glycosphingolipids and methods of use thereof
发明人：OH SUNGWHAN; KASPER DENNIS L; SONG HEEBUM; PARK SEUNG BUM
权利人:HARVARD COLLEGE; SEOUL NAT UNIV R&DB FOUNDATION
摘要:Provided herein are a subset of alpha-galactosylceramide (alpha-GC) compounds having improved immunomodulatory activity, particularly with respect to NKT cell number and activity. Also provided herein are methods of use of such compounds, including in the modulation of NKT cells and/or activity in vivo. Further provided are combinatorial synthesis methods for generating alpha-GC compounds of specifically defined structure and thereby generating pure preparations thereof.

专利号:US-9907753-B2
优先权日:2010-03-19
标 题 :Lipid vesicle compositions and methods of use
发明人：IRVINE DARRELL J; MOON JAEHYUN
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.