CAS: 454-78-4; 2-Bromo-1-Chloro-4-(Trifluoromethyl)Benzene

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CAS号98-56-6 4-氯三氟甲苯 | CAS号5216-25-1 对氯三氯甲苯 | CAS号7439-89-6 铁粉 | CAS号74-11-3 对氯苯甲酸 | CAS号32137-20-5 1-氯-2-氟-4-(三氟甲基)苯 | CAS号657-05-6 2-氯-5-(三氟甲基)苯甲酰氯 | CAS号657-06-7 2-氯-5-(三氟甲基)苯甲酸 | CAS号1146214-95-0 2-氯-5-(三氟甲基)苯硼酸频呢醇酯 | CAS号50594-35-9 2-bromo-1-pheno... | CAS号397-50-2 3-(trifluoromet...

专利信息

专利号:US-2011301143-A1
优先权日:2009-02-23
标题 :Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
权利人:ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
摘要:Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, Câ•?CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.

专利号:RU-2440355-C2
优先权日:2006-04-03
标 题:Method for synthesis of organoelement compounds