CAS: 5308-28-1; 1-Isobutylpiperazine

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CAS号629625-93-0 benzyl 4-isobut... | CAS号110-85-0 哌嗪 | CAS号78-77-3 溴代异丁烷

Tert-Butyl 4-(2-Methylpropyl)Piperazine-1-Carboxylate置于三氟乙酸体系中,化学反应 16.0H,反应生成 N-异丁基哌嗪
参考文献:喹诺酮类抗生素对分枝杆菌的构效关系:在n-1和c-7处结构变化的影响.
标题:喹诺酮类抗生素对分枝杆菌的构效关系:在n-1和c-7处结构变化的影响.
摘要:对常规药物治疗有抵抗力的结核感染的再次出现表明需要针对结核分枝杆菌的替代化学疗法.作为优化针对结核分枝杆菌的喹诺酮类抗菌药物研究的一部分,我们准备了一系列n-1-和c-7取代的喹诺酮类化合物,以研究这两个位置上喹诺酮类修饰物与活性之间的特定结构-活性关系.对抗分枝杆菌.通过文献方法合成的化合物被评估了对福分枝杆菌和耻垢分枝杆菌以及革兰氏阴性和革兰氏阳性细菌的活性.化合物对堡垒分枝杆菌的活性用作结核分枝杆菌活性的晴雨表.
DOI:10.1021/jm9507082

专利信息

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:US-2009105156-A1
优先权日:2007-10-04
标 题:Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides

专利号:RU-2041210-C1
优先权日:1989-11-01
标题:Method of synthesis of imidazo-(4,5-b)-quinolinylhydroxyalkanoic acid amides or their pharmaceutically used salts

专利号:US-9676721-B2
优先权日:2010-09-03
标题 :Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BUCKMELTER ALEXANDRE J; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below.

专利号:US-9555039-B2
优先权日:2011-05-09
标题:Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT)
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; KUNTZ JUDITH D; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; FORMA TM LLC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An illustrative compound of the invention is shown below: Formula (I)

专利号:CN-105283442-B
优先权日:2013-04-04
标题 :Method for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine